Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network

Usui, Chie; Kirino, Eiji; Tanaka, Shoji; Inami, Rie; Nishioka, Kenya; Hatta, Kotaro; Nakajima, Takeshi; Nishioka, Kusuki; Inoue, Reiichi

doi:10.1093/pm/pnaa071

Cited by 25 publications

(21 citation statements)

References 26 publications

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“…It also seems that some treatments that reduce pain in FM produce a change in brain connectivity, including the insula and the cingulate cortex, as in our study [ 61 ]. Physical exercise interventions also seem to normalize aberrant resting state functional connectivity in FM patients and to be associated with pain improvement [ 62 ].…”

Section: Discussionsupporting

confidence: 55%

Fibromyalgia Detection Based on EEG Connectivity Patterns

Martín-Brufau

Gómez

Sánchez-Sánchez-Rojas

et al. 2021

JCM

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Objective: The identification of a complementary test to confirm the diagnosis of FM. The diagnosis of fibromyalgia (FM) is based on clinical features, but there is still no consensus, so patients and clinicians might benefit from such a test. Recent findings showed that pain lies in neuronal bases (pain matrices) and, in the long term, chronic pain modifies the activity and dynamics of brain structures. Our hypothesis is that patients with FM present lower levels of brain activity and therefore less connectivity than controls. Methods: We registered the resting state EEG of 23 patients with FM and compared them with 23 control subjects’ resting state recordings from the PhysioBank database. We measured frequency, amplitude, and functional connectivity, and conducted source localization (sLORETA). ROC analysis was performed on the resulting data. Results: We found significant differences in brain bioelectrical activity at rest in all analyzed bands between patients and controls, except for Delta. Subsequent source analysis provided connectivity values that depicted a distinct profile, with high discriminative capacity (between 91.3–100%) between the two groups. Conclusions: Patients with FM show a distinct neurophysiological pattern that fits with the clinical features of the disease.

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Section: Discussionsupporting

confidence: 55%

Fibromyalgia Detection Based on EEG Connectivity Patterns

Martín-Brufau

Gómez

Sánchez-Sánchez-Rojas

et al. 2021

JCM

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“…Such cross-network connectivity changes could indicate implicit neurophysiological alterations for sensorimotor or pain perception. For the pain perception, Coppola et al demonstrated that greater subjective intensity of pain during a migraine attack was associated with weaker DMN-insula connectivity ( 46 ), and Usui et al also presented that the DMN-insula connectivity changes correlated with the difference in pain scores of patients with fibromyalgia after music intervention ( 47 ). Chronic pain is common among the ESRD population but is usually underestimated ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline

Chang

et al. 2021

Front. Med.

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Background: Functional connectivity detected by resting-state functional MRI (R-fMRI) helps to discover the subtle changes in brain activities. Patients with end-stage renal disease (ESRD) on hemodialysis (HD) have impaired brain networks. However, the functional changes of brain networks in patients with ESRD undergoing peritoneal dialysis (PD) have not been fully delineated, especially among those with preserved cognitive function. Therefore, it is worth knowing about the brain functional connectivity in patients with PD by using R-fMRI.Methods: This case-control study prospectively enrolled 19 patients with ESRD receiving PD and 24 age- and sex- matched controls. All participants without a history of cognitive decline received mini-mental status examination (MMSE) and brain 3-T R-fMRI. Comprehensive R-fMRI analyses included graph analysis for connectivity and seed-based correlation networks. Independent t-tests were used for comparing the graph parameters and connectivity networks between patients with PD and controls.Results: All subjects were cognitively intact (MMSE > 24). Whole-brain connectivity by graph analysis revealed significant differences between the two groups with decreased global efficiency (Eglob, p < 0.05), increased betweenness centrality (BC) (p < 0.01), and increased characteristic path length (L, p < 0.01) in patients with PD. The functional connections of the default-mode network (DMN), sensorimotor network (SMN), salience network (SN), and hippocampal network (HN) were impaired in patients with PD. Meanwhile, in DMN and SN, elevated connectivity was observed in certain brain regions of patients with PD.Conclusion: Patients with ESRD receiving PD had specific disruptions in functional connectivity. In graph analysis, Eglob, BC, and L showed significant connectivity changes compared to the controls. DMN and SN had the most prominent alterations among the observed networks, with both decreased and increased connectivity regions. Our study confirmed that significant changes in cerebral connections existed in cognitively intact patients with PD.

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“…Moreover, the negative connectivity between the LPFC and posterior cingulate cortex/retrosplenial cortex in the maintenance phase is nullified in the encoding and retrieval phases, whereas the connectivity between the left LPFC and IPL became positive. Recently, we observed a similar phenomenon of dynamic changes in functional connectivity in patients with fibromyalgia (Usui et al, 2020). The patients listened to a piece of classical music, "Duo for Violin and Viola in G Major, K.423" by W. A. Mozart, with fMRI being performed before and after the session.…”

Section: Disinhibitionmentioning

confidence: 82%

The Precuneus Contributes to Embodied Scene Construction for Singing in an Opera

Tanaka

Kirino

2021

Front. Hum. Neurosci.

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Performing an opera requires singers on stage to process mental imagery and theory of mind tasks in conjunction with singing and action control. Although it is conceivable that the precuneus, as a posterior hub of the default mode network, plays an important role in opera performance, how the precuneus contributes to opera performance has not been elucidated yet. In this study, we aimed to investigate the contribution of the precuneus to singing in an opera. Since the precuneus processes mental scenes, which are multimodal and integrative, we hypothesized that it is involved in opera performance by integrating multimodal information required for performing a character in an opera. We tested this hypothesis by analyzing the functional connectivity of the precuneus during imagined singing and rest. This study included 42 opera singers who underwent functional magnetic resonance imaging when performing “imagined operatic singing” with their eyes closed. During imagined singing, the precuneus showed increased functional connectivity with brain regions related to language, mirror neuron, socio-cognitive/emotional, and reward processing. Our findings suggest that, with the aid of its widespread connectivity, the precuneus and its network allow embodiment and multimodal integration of mental scenes. This information processing is necessary for imagined singing as well as performing an opera. We propose a novel role of the precuneus in opera performance.

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Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network

Cited by 25 publications

References 26 publications

Fibromyalgia Detection Based on EEG Connectivity Patterns

Fibromyalgia Detection Based on EEG Connectivity Patterns

Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline

The Precuneus Contributes to Embodied Scene Construction for Singing in an Opera

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