Music intervention improves spatial learning and memory and alters serum proteomics profiling in rats

Abstract

Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein expression profiling was examined using magnetic bead-based matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF-MS). MI improved spatial learning and memory in both male and female rats. Peak 1708.61 (m/z values) was significantly increased in MI females vs. female controls. Peak 3925.09 (m/z values) was significantly reduced in MI males versus male controls. The two differential serum peptide peaks (m/z values: 1708.61, 3925.09) were further sequence identified as regions of proteins Desmin and Acsm1. Western blot and immunofluorescence testing of Desmin expression showed consistent results on proteomics analysis. MI plays an important role in behavioral cognition and protein expression in rats. This study provides a foundation in proteomics that suggests that MI might improve spatial learning and memory ability.

Uso de la música para modular la memoria: Una revisión sistemática

“…Vinculadas a la música y orientadas a personas con o sin conocimientos musicales, estas propuestas incluyen tocar un instrumento musical, escuchar música, crear música, las cuales estimulan una gran variedad de funciones cognitivas, entre ellas la memoria (Zatorre & McGill, 2005) La exposición a un estímulo musical podría mejorar el desempeño cognitivo gracias a la modificación afectiva, emocional y fisiológica que la música induce (Altenmüller & Schlaug, 2015); (Rickard, Toukhsati, & S., 2005); (Rickard, Wing, & Velik, 2012). En efecto, el arousal emocional inducido musicalmente se encuentra acompañado por la liberación de neuroquímicos que moderan el desempeño cognitivo, así como por la liberación de los neurotransmisores involucrados en los mecanismos de recompensa y de placer (Chanda & Levitin, 2013), lo que puede resultar en el refuerzo de los procesos de formación de la memoria (Ferreri & Rodriguez-Fornells, 2017) tanto en modelos animales (Psyrdellis, Diaz Abarahan, Cetratelli, & Justel, 2017;Xiong, y otros, 2018) como humanos (Justel, O´Conor, & Rubinstein, 2013;Justel, Diaz Abrahan, Castro, & Rubinstein, 2016). En este punto se puede hacer una distinción entre diseños metodológicos donde la música está presente de forma simultánea al aprendizaje de una tarea, actuando sobre la fase de codificación (Ferreri & Rodriguez-Fornells, 2017), o de forma posterior a ella, afectando la consolidación de la memoria (Justel, Psyrdellis, & Ruetti, 2013;Justel, Diaz Abrahan, Castro, & Rubinstein, 2016).…”

The Effects of Sounds and Music on Cells and Organisms: A Promising and Developing Area of Research

“…Several results were also been obtained in monkeys: music can have effects in decreasing the heartrate of baboons, increasing the social behaviour in chimpanzees, or inducing an abnormal behaviour in rhesus macaques (Dhungana et al 2018). In rats, music might improve spatial learning and memory ability (Xiong et al 2018).…”

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“…Several results were also been obtained in monkeys: music can have effects in decreasing the heartrate of baboons, increasing the social behaviour in chimpanzees, or inducing an abnormal behaviour in rhesus macaques (Dhungana et al 2018). In rats, music might improve spatial learning and memory ability (Xiong et al 2018).…”