Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Almeida, Joana Sa de; Lordier, Lara; Zollinger, Benjamin; Kunz, Nicolas; Bastiani, Matteo; Gui, Laura; Adam‐Darqué, Alexandra; Borradori-Tolsa, Cristina; Lazeyras, François; Hüppi, Petra Susan

doi:10.1016/j.neuroimage.2019.116391

Cited by 54 publications

(50 citation statements)

References 145 publications

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“…Music therapy, therefore, may be beneficial for the tiniest infants already from the very beginning, since these infants are already able to respond adequately to sounds ( 19 ). Studies on music in preterm infants report that music may enhance formation and maturation of structural brain networks involved in cognition and emotion regulation ( 20 , 21 ). It is therefore hypothesized that early auditory experiences are associated with structural brain development ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Live-Performed Music Therapy for Extremely and Very Preterm Infants in a Tertiary NICU

et al. 2020

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Objective: We aimed to investigate the feasibility of live-performed music therapy for extremely and very preterm infants admitted to the neonatal intensive care unit (NICU), and their parents, starting the 1st−2nd week after birth. They may benefit from live-performed music therapy as comforting non-pharmacological intervention. Study Design: We included infants born before 30 weeks' gestation in a single center NICU study. Live-performed music therapy was provided three times per week, tailored to the infant's medical condition. Parents were actively involved. Feasibility was determined as a combination of participation, drop-out, overstimulation (based on COMFORT-Neo scores), and evaluations of the intervention by parents and nurses (using a questionnaire on perceived effects on the parent, their infant and the NICU sound environment). Results: We included 18 infants (90% participation rate), with a gestational age of median 27 weeks (IQR 26–28 weeks), 61% males. One infant (5.6%) dropped-out. Differences of COMFORT-Neo scores during and after sessions compared with before sessions were non-significant; overstimulation by music therapy did not occur. Parents reported high satisfaction (highest score possible of 7) with the interventions and reported improvements in both infant and their own respiratory rates. Nurses also reported high satisfaction with the intervention and perceived a quieter NICU sound environment during and after sessions. Conclusion: Live-performed music therapy for extremely and very preterm infants is feasible and well-tolerated, and is experienced as an added value to developmental care. Future studies should assess both short-term and long-term effects, to determine whether this intervention should be part of routine care at the NICU and whether it is most beneficial to start shortly after birth.

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Section: Discussionmentioning

confidence: 99%

Feasibility of Live-Performed Music Therapy for Extremely and Very Preterm Infants in a Tertiary NICU

et al. 2020

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“…These auditory and tactile interventions can be viewed as environmental enrichment, possibly stimulating cortical plasticity and attenuating the stress response in preterm infants (298). Indeed, recent studies found encouraging, but preliminary, evidence for increased microstructural maturation at term-equivalent age for preterm infants exposed to music during their NICU stay (299), as well as a greater maturation of cardiac function (296). In the long-term, both Family Integrated Care, i.e., infant care provided by families by enhancing parental support and education (300), and Family Nurture Interventions, i.e., promotes calming interaction between mother and infants, seem to have a sustained positive effect of behavioral outcome, with more robust self-regulation skills and less negative emotionality at 18-21 months and 4-5 years of age, amongst others (297,301,302).…”

Section: Opportunities For Early Interventionmentioning

confidence: 99%

Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability

et al. 2021

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The third trimester of pregnancy represents a sensitive phase for infant brain plasticity when a series of fast-developing cellular events (synaptogenesis, neuronal migration, and myelination) regulates the development of neural circuits. Throughout this dynamic period of growth and development, the human brain is susceptible to stress. Preterm infants are born with an immature brain and are, while admitted to the neonatal intensive care unit, precociously exposed to stressful procedures. Postnatal stress may contribute to altered programming of the brain, including key systems such as the hypothalamic–pituitary–adrenal axis and the autonomic nervous system. These neurobiological systems are promising markers for the etiology of several affective and social psychopathologies. As preterm birth interferes with early development of stress-regulatory systems, early interventions might strengthen resilience factors and might help reduce the detrimental effects of chronic stress exposure. Here we will review the impact of stress following premature birth on the programming of neurobiological systems and discuss possible stress-related neural circuits and pathways involved in resilience and vulnerability. Finally, we discuss opportunities for early intervention and future studies.

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“…[22] The EmC fibers play a role in semantic processing and language development, proved by the following observations: Immaturity of these pathways (EmC and UF) in premature newborns and maturity or increased functional connections following music therapy. [23] Increased testosterone levels is associated with increased functional connections and the integrity of the fibers coursing the white matter structure of the EmC. The fibers appear to be the thicker (shown by higher fractional anisotropy), in boys with higher testosterone levels, and respectively thinner, in those less skilled in language than girls.…”

Section: Human Language Development and Cognitive Language Functionsmentioning

confidence: 95%

Extreme Capsule is a Bottleneck for Ventral Pathway

Shekari¹,

Shahriari²,

Joghataei³

2020

Preprint

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On review of neuroscience literature extreme capsule considered as a whiter matter tract. Nevertheless it is not clear that extreme capsule itself is a association fiber pathway or is o bottleneck for passing other association fiber. By a systematic search with investigating anatomical position, dissection, connectivity and cognitive role of extreme capsule it can be argued that extreme capsule probably is a bottleneck for passing uncinated fasciculus (UF) and inferior fronto – occipital fasciculus(IFOF), And its different role of language processing is duo to different tract that passing it.

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Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Cited by 54 publications

References 145 publications

Feasibility of Live-Performed Music Therapy for Extremely and Very Preterm Infants in a Tertiary NICU

Feasibility of Live-Performed Music Therapy for Extremely and Very Preterm Infants in a Tertiary NICU

Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability

Extreme Capsule is a Bottleneck for Ventral Pathway

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