Music and the nucleus accumbens

Mavridis, Ioannis N.

doi:10.1007/s00276-014-1360-0

Cited by 25 publications

(10 citation statements)

References 16 publications

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“…Music listening can influence a person's emotions and moods (Bennett and Lengacher, 2009; Mavridis, 2015) by activating specific pleasure areas in the limbic system, such as the nucleus accumbens, amygdala, and hippocampus (Blood and Zatorre, 2001; Menon and Levitin, 2005; Berridge and Kringelbach, 2015; Mavridis, 2015). These activations in turn may release neuropeptides, such as dopamine, and endogenous opioids (Blood and Zatorre, 2001; Mavridis, 2015). It cannot be excluded that such effects also occur in animals.…”

Section: Introductionmentioning

confidence: 99%

Music Affects Rodents: A Systematic Review of Experimental Research

Kühlmann

Rooij

Hunink

et al. 2018

Front. Behav. Neurosci.

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Background: There is rapidly emerging interest in music interventions in healthcare. Music interventions are widely applicable, inexpensive, without side effects, and easy to use. It is not precisely known how they exert positive effects on health outcomes. Experimental studies in animal models might reveal more about the pathophysiological mechanisms of music interventions.Methods: We performed a systematic review of experimental research in rodents. The electronic databases EMBASE, Medline(ovidSP), Web-Of-Science, PsycINFO, Cinahl, PubMed publisher, Cochrane, and Google scholar were searched for publications between January 1st 1960 and April 22nd 2017. Eligible were English–written, full-text publications on experimental research in rodents comparing music vs. a control situation. Outcomes were categorized in four domains: brain structure and neuro-chemistry; behavior; immunology; and physiology. Additionally, an overview was generated representing the effects of various types of music on outcomes. Bias in studies was assessed with the SYRCLE Risk of Bias tool. A meta-analysis was not feasible due to heterogeneous outcomes and lack of original outcome data.Results: Forty-two studies were included. Music-exposed rodents showed statistically significant increases in neuro-chemistry, such as higher BDNF levels, as well as an enhanced propensity for neurogenesis and neuroplasticity. Furthermore, music exposure was linked with statistically significantly improved spatial and auditory learning, reduced anxiety-related behavior, and increased immune responses. Various statistically significant changes occurred in physiological parameters such as blood pressure and (para)sympathetic nerve activity following music interventions. The majority of studies investigated classical music interventions, but other types of music exerted positive effects on outcomes as well. The SYRCLE risk of bias assessment revealed unclear risk of bias in all studies.Conclusions: Music interventions seem to improve brain structure and neuro-chemistry; behavior; immunology; and physiology in rodents. Further research is necessary to explore and optimize the effect of music interventions, and to evaluate its effects in humans.

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Section: Introductionmentioning

confidence: 99%

Music Affects Rodents: A Systematic Review of Experimental Research

Kühlmann

Rooij

Hunink

et al. 2018

Front. Behav. Neurosci.

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“…Pleasurable experiences have been shown to lead to the release of certain neurotransmitters including serotonin, which is produced in the nucleus accumbens (NAc) and hypothalamic regions of the brain (Chanda & Levitin, 2013;Mavridis, 2015;Menon & Levitin, 2005;Taylor, 1997). In fact, Mavridis referred to the nucleus accumbens as, "the most important pleasure center of the human brain (dominates the reward system)…" (2015, p. 121), and reported that "…reward value for music can be coded by activity levels in the NAc, whose functional connectivity with auditory and frontal areas increases as a function of increasing musical reward" (p. 121).…”

Section: Music Reward and Neurobiologymentioning

confidence: 99%

The Impact of Singing Engagement on Food Intake of Individuals with Alzheimer’s Disease and Related Dementias: A Multi-site, Repeated Measures Study

Hiller

2020

Voices

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Malnutrition among older adults with Alzheimer’s disease and related dementias (ADRD) is a serious and long-recognized health concern. Identifying nonpharmacological means for enhancing the volume of nutrition intake is an urgent need. Researchers have explored the use of music and music therapy as nonpharmacological avenues in this regard, but most music-based studies related to food intake focus on receptive interventions wherein participants are exposed to recorded music during meal times. The purpose of the present research is to investigate whether residents with ADRD would significantly increase their volume of food intake during the midday meal immediately following 30 minutes of active singing engagement facilitated by a board-certified music therapist (MT-BC). Results indicated no significant change in food intake for participants with ADRD in three long-term care facilities. However, the unintended finding at two facilities wherein participants’ food intake was greater during baseline weeks versus treatment weeks led to speculation about the impact of serotonin which researchers report is released during enjoyable music engagement episodes, but that has also long been recognized as an appetite suppressant. With this newly interpreted finding, recommendation is offered for monitoring when music therapy is provided for individuals with ADRD and nutritional complications relative to their meal times toward minimizing potential adverse effects.

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“…More importantly: it is intrinsically pleasurable. Listening to music stimulates activity in brain regions dedicated to processing rewards (Zatorre and Salimpoor ; Mavridis ), and musical pleasure is specifically associated with increased functional connectivity between these reward‐processing regions and other cortical networks focused on motor control and prediction (Salimpoor et al. ).…”

Section: The Brute Facts About Ecstasymentioning

confidence: 99%

Antistructure and the Roots of Religious Experience

Wood¹

2020

Zygon

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The cognitive and evolutionary sciences of religion offer a standard model of religious representations, but no equivalent paradigm for investigating religiously interpreted altered states of consciousness (religious ASCs). Here, I describe a neo-Durkheimian framework for studying religious ASCs that centralizes social predictive cognition. Within a processual model of ritual, ritual behaviors toggle between reinforcing normative social structures and downplaying them. Specifically, antistructural ritual shifts cognitive focus away from conventional affordances, collective intentionality, and social prediction, and toward physical affordances and behavioral motivations that make few references to others' intentional states. Using synchrony and dance as paradigmatic examples of antistructural ritual that stimulate religious ASCs, I assemble literature from anthropology, cognitive neuroscience, and philosophy of language to offer fruitful empirical predictions and opportunities for testing based on this framework. Among the empirical predictions is that antistructural ritual may provide for cultural change in religions when religions are construed as complex adaptive systems.

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Music and the nucleus accumbens

Cited by 25 publications

References 16 publications

Music Affects Rodents: A Systematic Review of Experimental Research

Music Affects Rodents: A Systematic Review of Experimental Research

The Impact of Singing Engagement on Food Intake of Individuals with Alzheimer’s Disease and Related Dementias: A Multi-site, Repeated Measures Study

Antistructure and the Roots of Religious Experience

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