Mushrooms Bioactive as Prebiotics to Modulate Gut Microbiota in Relationships with Causes and Prevention of Liver Diseases (Review)

Tsopmejio, Ivan Stève Nguepi; Song, Hui

doi:10.1615/intjmedmushrooms.2020034706

Cited by 10 publications

(2 citation statements)

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“… 39 Furthermore, the main metabolic pathway of magnesium ions is the kidney, 40 and the liver is the organ that first filters toxins, nutrients, and bacterial metabolites. 41 Thus, it can be inferred that these two organs are easily damaged when clips are implanted into the body. However, our results suggest that liver and kidney functions were not affected ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Corrosion and biocompatibility behaviours of microarc oxidation/phytic acid coated magnesium alloy clips for use in cholecystectomy in a rabbit model

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Corrosion and biocompatibility behaviours of microarc oxidation/phytic acid coated magnesium alloy clips for use in cholecystectomy in a rabbit model

et al. 2021

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“…Under normal conditions, the gut microbiota and the host coexist harmoniously, and gut microbiota play important roles in maintaining a normal immune system, preventing pathogenic bacteria from colonizing the body, and the digestion and absorption of nutrients. When the gut microbiota composition changes, symbiotic disorders can occur, causing various diseases [5][6][7][8][9]. A large number of experiments have shown that the occurrence and development of liver diseases are closely related to changes in gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Leng¹,

Wang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background: Ganoderma lucidum spore powder (GLSP) has abundant pharmacological activities. However, the difference in the hepatoprotective function of sporoderm-broken and sporoderm-unbroken Ganoderma spore powder has not been studied. This study is the first to investigate the effects of both sporoderm-damaged and sporoderm-intact GLSP on the improvement of acute alcoholic liver injury in mice and gut microbiota of mice. Methods: Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and interleukin 1β (IL-1β), interleukin 18 (IL-18), and tumor necrosis factor-α (TNF-α) levels in liver tissues from mice in each group were detected by enzyme-linked immunosorbent assay (ELISA) kits, and histological analysis of liver tissue sections was performed to evaluate the liver-protecting effects of both sporoderm-broken and sporoderm-unbroken GLSP. Additionally, 16S rDNA sequencing of feces from the bowels of mice was performed to compare the regulatory effects of both sporoderm-broken and sporoderm-unbroken GLSP on the gut microbiota of mice. Results: Compared with those in the 50% ethanol model group (MG), sporoderm-broken GLSP significantly reduced serum AST and ALT levels (p < 0.0001) and the release of the inflammatory factors, including IL-1β, IL-18, and TNF-α (p < 0.0001), and effectively improved the pathological state of liver cells; sporoderm-unbroken GLSP significantly reduced the ALT content (p = 0.0002) and the release of the inflammatory factors, including IL-1β (p < 0.0001), IL-18 (p = 0.0018), and TNF-α (p = 0.0005), and reduced the serum AST content, but the reduction was not significant; compared with the gut microbiota of the MG, sporoderm-broken GLSP reduced the levels of Verrucomicrobia and Escherichia_Shigella, increased the relative abundance of beneficial bacteria such as Bacteroidetes, and decreased the abundance levels of harmful bacteria, such as Proteobacteria and Candidatus_Saccharibacteria; sporoderm-unbroken GLSP could reduce the abundance levels of harmful bacteria, such as Verrucomicrobia and Candidatus_Saccharibacteria; and GLSP treatment alleviates the downregulation of the levels of translation, ribosome structure and biogenesis, and lipid transport and metabolism in liver-injured mice; Conclusions: GLSP can alleviate the imbalance of gut microbiota and improve liver injury, and the effect of sporoderm-broken GLSP is better.

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Mechanisms Involved in Edible Mushrooms’ Health Beneficial Effects

Pelinescu

Stoica

2023

Mushrooms With Therapeutic Potentials

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Mushrooms Bioactive as Prebiotics to Modulate Gut Microbiota in Relationships with Causes and Prevention of Liver Diseases (Review)

Cited by 10 publications

References 0 publications

Corrosion and biocompatibility behaviours of microarc oxidation/phytic acid coated magnesium alloy clips for use in cholecystectomy in a rabbit model

Corrosion and biocompatibility behaviours of microarc oxidation/phytic acid coated magnesium alloy clips for use in cholecystectomy in a rabbit model

Protective Effect of Ganoderma lucidum Spore Powder on Acute Liver Injury in Mice and its Regulation of Gut Microbiota

Mechanisms Involved in Edible Mushrooms’ Health Beneficial Effects

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