Mushroom Polysaccharides as Potential Candidates for Alleviating Neurodegenerative Diseases

Jiang, Xue; Li, Siqi; Li, Lanzhou; Huang, Jie; Wang, Di; Wang, Qingshuang

doi:10.3390/nu14224833

Cited by 12 publications

(8 citation statements)

References 103 publications

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“…Differences in molecular weight, branching configuration, conformation, and chemical modification of polysaccharides provide the basis for their diverse biological activities, such as antitumor, antioxidant, and anti-inflammatory effects ( Maity et al., 2021 ). These medicinal functions have also been detected in Sanghuangporus ( Jiang et al., 2021 ; Jiang et al., 2022 ). Here, for the first time, we identified a polysaccharide biosynthesis pathway in S. weigelae , namely the starch and sucrose metabolism pathway, which involved 48 genes ( Supplementary Figure S3 ; Supplementary Table S2 ).…”

Section: Discussionmentioning

confidence: 85%

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

Jin,

Ma,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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Sanghuangporus, also known as “Sanghuang” in China, is a well-known genus of traditional Chinese medicinal macrofungi. To make more effective use of Sanghuangporus resources, we completed the first genome assembly and annotation of a monokaryon strain of S. weigelae in the present study. A 33.96-Mb genome sequence was assembled as 13 contigs, leading to prediction of 9377 protein-coding genes. Phylogenetic and average nucleotide identity analyses indicated that the S. weigelae genome is closely related to those of other Sanghuangporus species in evolutionary tree, which clustered in one clade. Collinearity analysis revealed a high level of collinearity of S. weigelae with S. baumii, S. vaninii, and S. sanghuang. Biosynthesis pathways potentially involved in medicinal properties, including terpenoid and polysaccharide synthesis, were identified in S. weigelae, while polysaccharides were identified as the main medicinal metabolites in S. weigelae, with flavonoids more important in Sanghuangporus than other medicinal mushroom groups. Genes encoding 332 carbohydrate-active enzymes were identified in the S. weigelae genome, including major glycoside hydrolases and glycosyltransferases predicted, revealing the robust lignocellulose degradation capacity of S. weigelae. Further, 130 genes, clustered in seven classes were annotated to encode cytochromes P450 in the S. weigelae genome. Overall, our results reveal the remarkably medicinal capacity of S. weigelae and provide new insights that will inform the study of evolution and medicinal application of S. weigelae. The data are a reference resource for the formulation of scientific and rational ecological protection policies for Sanghuangporus species.

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Section: Discussionmentioning

confidence: 85%

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

Jin,

Ma,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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“…However, the etiology of this disease has unfortunately yet to be fully clarified, and this is a limiting factor in its prevention and control [ 26 ]. Nevertheless, the following cellular and molecular events associated with the occurrence and progression of AD are widely accepted ( Figure 2 ) [ 13 , 27 ].…”

Section: The Main Targets For Treating Alzheimer’s Diseasementioning

confidence: 99%

Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer’s Diseases

et al. 2023

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Mushrooms with edible and medicinal potential have received widespread attention because of their diverse biological functions, nutritional value, and delicious taste, which are closely related to their rich active components. To date, many bioactive substances have been identified and purified from mushrooms, including proteins, carbohydrates, phenols, and vitamins. More importantly, molecules derived from mushrooms show great potential to alleviate the pathological manifestations of Alzheimer’s disease (AD), which seriously affects the health of elderly people. Compared with current therapeutic strategies aimed at symptomatic improvement, it is particularly important to identify natural products from resource-rich mushrooms that can modify the progression of AD. This review summarizes recent investigations of multiple constituents (carbohydrates, peptides, phenols, etc.) isolated from mushrooms to combat AD. In addition, the underlying molecular mechanisms of mushroom metabolites against AD are discussed. The various mechanisms involved in the antiAD activities of mushroom metabolites include antioxidant and anti-neuroinflammatory effects, apoptosis inhibition, and stimulation of neurite outgrowth, etc. This information will facilitate the application of mushroom-derived products in the treatment of AD. However, isolation of new metabolites from multiple types of mushrooms and further in vivo exploration of the molecular mechanisms underlying their antiAD effect are still required.

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“…The possible mechanisms of action of edible mushrooms on preventing several agebased neuronal diseases are still undisclosed, but it is advocated that they could contribute through a reduction in oxidative stress, neuroinflammation, and on the modulation of acetylcholinesterase activity, protecting neurons or stimulation, and regulating neurotrophins synthesis, on the rough endoplasmic reticulum [106,107].…”

Section: Mushroom Nutrition In Neurodegenerative Diseasesmentioning

confidence: 99%

Mushrooms as Functional Foods for Ménière’s Disease

Bell,

Fernandes

2023

Applied Sciences

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Food, not nutrients, is the fundamental unit in nutrition, and edible mushrooms are fungi that supply unique biological bioactive compounds, different from plant or animal origin, which significantly impact human health status. However, to date all these concepts are interpreted in different ways, with rapidly increasing knowledge on nutrition, medicine, molecular biology, and plant biotechnology changing the concepts of food, health, and agriculture. The bioactive elements conveyed by foodstuffs as nutrients or non-nutrients interfere with human metabolism and have influence on health, aging, and well-being. The influence of edible mushrooms on medicinal interventions has been known and studied for many years and their latest role in neurodegenerative disorders has been recently investigated, while their significance on many other diseases has been well demonstrated. Despite considerable research, the etiology and pathogenesis of Ménière’s disease remains controversial and undefined, although usually associated with allergic, genetic, or trauma sources, and with viral infections and/or immune system-mediated mechanisms. With treatment still unknown, our attention is towards the eventual impact of complementary dietary interventions, synthesizing the recent knowledge of some edible mushrooms and preparations on Ménière’s disease, which is a lifelong condition that can develop at any age, but most commonly emerges between 40 and 60 years of age. It is demonstrated that the oral administration of a biomass preparation, with 3 g/day of the mushroom Coriolus versicolor for 2 to 6 months, on some 40 human Ménière’s disease patients reduced systemic oxidative stress and cellular stress response, decreased the number of crises and their duration, and the frequency of symptoms, improving the clinical grading of tinnitus severity.

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Mushroom Polysaccharides as Potential Candidates for Alleviating Neurodegenerative Diseases

Cited by 12 publications

References 103 publications

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

First genome assembly and annotation of Sanghuangporus weigelae uncovers its medicinal functions, metabolic pathways, and evolution

Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer’s Diseases

Mushrooms as Functional Foods for Ménière’s Disease

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