Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc mice

Khan, Imran; Huang, Guoxin; Li, Xiao-ang; Liao, Wei-Lin; Leong, Wai Kit; Xia, Wenrui; Bian, Xiqing; Wu, Jian‐Lin; Hsiao, W.L. Wendy

doi:10.1016/j.phrs.2019.104448

Cited by 73 publications

(55 citation statements)

References 53 publications

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“…This observation is in line with our previous finding in which high levels of serum SCFAs were significantly elevated in mice treated with GpS. 29 To further investigate whether GpS treatment could alter the biosynthesis and metabolism of the bacteria, we looked into the transcriptome of B. animalis in the presence and absence of GpS using RNAseq analysis. By comparing to the Ctrl, we identified 25 genes uniquely expressed in the GpS-treated culture of B. animalis.…”

Section: Discussionsupporting

confidence: 87%

“…We also demonstrated that the cancer-preventive effect of GpS might be through the modulation of the gut commensal bacteria. [27][28][29] Here, for the first time, we show that the GpS-responder B. animalis exhibits a potent anticancer activity in Apc Min/+ mice. Until now, most of the intestinal microbiota could not be easily cultured in the laboratory.…”

Section: Discussionmentioning

confidence: 66%

“…In our previous reports, 26,27,29 treatment with GpS boosted beneficial gut microbes and exerted prebiotic effects in both normal and Apc Min/+ mice. Therefore, in this study, we performed qPCR to survey the abundance of two major gut commensal phyla, i.e., Firmicutes and Bacteroidetes, among the experimental mice.…”

Section: Fecal Transplant Improves the Microbial Profiles Of The Apc mentioning

confidence: 82%

“…26 Further research showed that G. pentaphylum saponin (GpS) exerts significant cancer-preventive effects in Apc Min/+ mice through modulating the GM composition and the gut epithelial microenvironment. [27][28][29] We hypothesize that treatment with GpS might have preserved a particular group(s) of bacteria that provides health advantage to the host. In this current study, we performed both in vivo and in vitro experiments to track down the potential bacterial group(s) that confers the prebiotic and cancer-preventive effect of GpS.…”

Section: Introductionmentioning

confidence: 99%

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Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

et al. 2020

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Colorectal cancer (CRC) ranks the third most common cancer type in both men and women. Besides the known genetic and epigenetic changes in the gut epithelial cells, we now know that disturbed gut microbes could also contribute to the onset and progression of CRC. Hence, keeping a balanced gut microbiota (GM) has become a novel pursue in the medical field, particularly in the area of gastrointestinal disorders. Gynostemma pentaphyllum (Gp) is a dietary herbal medicine. In our previous study, Gp saponins (GpS) displayed prebiotic and cancer-preventive properties through the modulation of GM in Apc Min/+ mice. However, the specific group(s) of GM links to the health effects of GpS remains unknown. To track down the missing link, we first investigated and found that inoculation with fecal materials from GpS-treated Apc Min/+ mice effectively reduces polyps in Apc Min/+ mice. From the same source of the fecal sample, we successfully isolated 16 bacterial species. Out of the 16 bacteria, Bifidobacterium animalis stands out as the responder to the GpS-growth stimulus. Biochemical and RNAseq analysis demonstrated that GpS enhanced expressions of a wide range of genes encoding biogenesis and metabolic pathways in B. animalis culture. Moreover, we found that colonization of B. animalis markedly reduces the polyp burden in Apc Min/+ mice. These findings reveal a mutualistic interaction between the prebiotic and a probiotic to achieve anticancer and cancer-preventive activities. Our result, for the first time, unveils the anticancer function of B. animalis and extend the probiotic horizon of B. animalis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 66%

Section: Fecal Transplant Improves the Microbial Profiles Of The Apc mentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

et al. 2020

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“…In fact, ~30% of the spontaneous tumours in this model had progressed to invasive cancer by 30 weeks of age, and the histopathology of multistage tumourigenesis closely resembled that of human CRC. In contrast, the widely used B6 Apc Min/+ mice develop multiple small intestinal ADs by 10-18 weeks of age, and the number of ADs in this mouse model has been used as a convenient indicator of tumourigenesis for studies on cancer prevention (34,35). However, in the B6 Apc Min/+ mouse model, the multistage carcinogenesis process cannot be analysed histopathologically due to its short lifespan (~150 days), which is caused by severe anaemia as a result of its heavy tumour burden.…”

Section: Discussionmentioning

confidence: 99%

Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 Apc^Min/+ Mice

et al. 2021

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Background/Aim: Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of a CR diet at different starting ages on radiation induction of intestinal tumours in mice. Materials and Methods: Male C3B6F1 Apc Min/+ mice were irradiated with 0 or 2 Gy of X-rays at 2 weeks of age. After an interval of 2, 8 or 18 weeks, mice were fed with a non-CR (95 kcal/week/mouse) or CR (65 kcal/week/mouse) diet. Intestinal tumours were evaluated for number, size distribution and malignancy. Results: CR suppressed the size and progression of both spontaneous and radiation-induced intestinal tumours depending on age at starting of CR. CR diets were effective even administered to adult mice. Conclusion: CR was effective for suppression of tumour progression, which was accelerated by radiation exposure. Use of CR might be a useful cancer-prevention strategy for radiation-induced tumours of the intestinal tract. Ionizing radiation has been recognized as a human and rodent carcinogen. Evidence for cancer risk is based on estimates from various sources, including analyses of atomic bomb survivors (1), nuclear power plant accident victims (2), 1365 This article is freely accessible online.

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Prebiotics and Probiotics as Anticancer Therapeutics

Chettri

Verma

2022

Prebiotics and Probiotics in Disease Regulation and Management

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Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc mice

Cited by 73 publications

References 53 publications

Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 Apc^Min/+ Mice

Prebiotics and Probiotics as Anticancer Therapeutics

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Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in Apc mice

Cited by 73 publications

References 53 publications

Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

Bifidobacterium animalis: the missing link for the cancer-preventive effect of Gynostemma pentaphyllum

Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 ApcMin/+ Mice

Prebiotics and Probiotics as Anticancer Therapeutics

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Calorie Restriction Suppresses the Progression of Radiation-Induced Intestinal Tumours in C3B6F1 Apc^Min/+ Mice