Mushroom insoluble polysaccharides prevent carbon tetrachloride-induced hepatotoxicity in rat

Nada, Somaia A.; Omara, Enayat A.; Abdel-Salam, Omar M.E.; Zahran, Hanan G.

doi:10.1016/j.fct.2010.08.019

Cited by 61 publications

(36 citation statements)

References 36 publications

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“…Pretreatment with the polysaccharides significantly ameliorated the tested parameters when compared with the carbon tetrachloride-treated group. Histopathological examination of the hepatic tissue revealed that polysaccharide administration alone protected hepatocytes from the damage induced by carbon tetrachloride [112]. Similar results were obtained in a study in which hot-water polysaccharopeptides from the culture broth of the P. ostreatus mycelium were tested against injury induced by thioacetamide in mice [113].…”

Section: Polyssacharide From Pleurotus Ostreatus Myceliumsupporting

confidence: 68%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Section: Polyssacharide From Pleurotus Ostreatus Myceliumsupporting

confidence: 68%

Hepatoprotective Effects of Mushrooms

et al. 2013

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“…The hepatic oxidative injury induced by CCl 4 was a well-characterized model system for screening hepatoprotective activity of antioxidants, because the exposure of CCl 4 exposure could result in trichloromethyl radicals-mediated hepatic necrosis and steatosis (Nada, Omara, Abdel-Salam, & Zahran, 2010). Thus, scavenging free radicals with various natural products provided quite important means to prevent from CCl 4 -induced liver damage.…”

Section: Discussionmentioning

confidence: 99%

Purification, characterization and hepatoprotective activities of mycelia zinc polysaccharides by Pleurotus djamor

Zhang

Liu

Yang

et al. 2016

Carbohydrate Polymers

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“…Administration of various natural extracts, such as those of Lygodium flexuosum (Wills & Asha, 2006), Cassia siamea flower (Kaur, Sarwar Alamb, Jabbar, Javed, & Athar, 2006), Cytisus scoparius (Raja et al, 2007), and Phyllanthus maderaspatensis (Asha, Sheeba, Suresh, & Wills, 2007), has been reported to exert a protective effect by reducing the level of MDA in liver tissues of rats given CCl 4 . Nada, Omara, Abdel-Salam, and Zahran (2010) have reported that the insoluble polysaccharides in mushroom prevent carbon tetrachloride-induced hepatotoxicity in rat. In our previous study, a decreased concentration of MDA was observed in liver, kidney, heart and brain of CCl 4 -induced rats that had been treated with mushroom P. ostreatus extract (Jayakumar, Ramesh, & Geraldine, 2006;Jayakumar, Sakthivel, Thomas, & Geraldine, 2008) ( Table 1).…”

Section: Inhibitory Effects On Lipid Peroxidation Induced By CCLmentioning

confidence: 99%