Musculoskeletal system pathology: focus on sarcopenia and osteosarcopenia

Aim. To determine the clinical profile of a patient with stable coronary artery disease (CAD) and impaired muscle status.Material and methods. The study included 387 patients with stable CAD who had indications for open myocardial revascularization. Quantification of muscle tissue was carried out using computed tomography. Comparative analysis of clinical and anamnestic characteristics of groups of patients with sarcopenia (n=152) and those with normal muscle status (n=235) was performed.Results. Signs of sarcopenia were found in 39,3% of patients with stable CAD. In the group of sarcopenia and the group with normal muscle status, there was a predominance of males — 86,2 and 64,7% (p=0,01), the presence of hypercholesterolemia — 51,3 and 31,1% (p=0,02), type 2 diabetes — 21,1 and 28,1% (p=0,06), multivessel CAD — 25,6 and 17,8% of cases (p=0,018), respectively. In sarcopenia, a 4 times longer history of diabetes was noted (p=0,01) and a 2,3 times longer duration of CAD (p=0,03). The prevalence of obesity in sarcopenia was 3,4 times less (p=0,003). Correlation analysis showed the relationship of muscle status with age (r=-0,674; p=0,002), duration of CAD history (r=-0,582; p=0,001) and diabetes (r=-0,748; p<0,001).Conclusion. The clinical and anamnestic profile of a patient with stable CAD and sarcopenia is characterized by an association of decreased muscle mass with male sex, hypercholesterolemia, multivessel coronary CAD, a long-term history of type 2 diabetes and angina.

show abstract

Profile of a patient with stable coronary artery disease and impaired muscle status

Kokov

Масенко

Kareeva

et al. 2023

Cardiovasc Ther Prev

View full text Add to dashboard Cite

show abstract

Modern guidelines for the diagnosis of sarcopenia

Golounina

Фадеев

Belaya³

2023

jour

View full text Add to dashboard Cite

Sarcopenia is a progressive generalized skeletal muscle disease characterized by loss of muscle mass and decreased muscle function with an increased risk of adverse events. For a long time, loss of muscle mass and function has been studied as a clinical symptom in severe diseases and conditions in oncology, endocrinology, rheumatology, and a number of other systemic diseases. However, with the increase in life expectancy and aging of the population, sarcopenia, as an independent age-associated disease, comes into general medical practice and makes a significant contribution to the rates of disability and mortality. To date, several definitions of sarcopenia, screening methods and diagnostic criteria for this disease have been proposed by various international research groups. This review presents evolution of definitions and diagnostic criteria for sarcopenia and severe sarcopenia. Changes in the algorithm for sarcopenia diagnostics according to the latest recommendations of the European Working Group on Sarcopenia for Older People (EWGSOP) second revision, published in 2018 (EWGSOP2), as well as the results of the consensus of the American Geriatric Society and the International Group on study of sarcopenia. This review summarizes practical issues regarding methods for assessing muscle mass, muscle strength and skeletal muscle function, diagnostics threshold for sarcopenia from leading international research groups, as well as the results of researchers’ work on adapting tests for assessing sarcopenia in Russia.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Musculoskeletal system pathology: focus on sarcopenia and osteosarcopenia

Cited by 2 publications

References 47 publications

Profile of a patient with stable coronary artery disease and impaired muscle status

Profile of a patient with stable coronary artery disease and impaired muscle status

Modern guidelines for the diagnosis of sarcopenia

Contact Info

Product

Resources

About