Musculoskeletal Regeneration, Rehabilitation, and Plasticity
                    Following Traumatic Injury

Greising, Sarah M.; Corona, Benjamin T.; Call, Jarrod A.

doi:10.1055/a-1128-7128

Cited by 33 publications

(34 citation statements)

References 107 publications

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“…The pathophysiologic comorbidities of VML injury are vast and range from functional deficits, impaired inflammatory signaling, denervation, and chronic fibrotic deposition [ 28 , 29 ]. However, to date both muscle-specific and whole-body metabolic consequences of VML injury are poorly understood, both in animal models and the patient population.…”

Section: Discussionmentioning

confidence: 99%

Independent of physical activity, volumetric muscle loss injury in a murine model impairs whole-body metabolism

et al. 2021

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Volumetric muscle loss (VML) injuries result in a non-recoverable loss of muscle tissue and function due to trauma or surgery. Reductions in physical activity increase the risk of metabolic comorbidities over time, and it is likely that VML may reduce whole-body activity. However, these aspects remain uncharacterized following injury. Our goal was to characterize the impact of VML on whole-body physical activity and metabolism, and to further investigate possible muscle-specific metabolic changes. Adult male C57Bl/6J (n = 28) mice underwent a standardized VML injury to the posterior compartment of the hind limb, or served as injury naïve controls. Mice underwent longitudinal evaluation of whole-body physical activity and metabolism in specialized cages up to three times over the course of 8 weeks. At terminal time points of 4- and 8-weeks post-VML in vivo muscle function of the posterior compartment was evaluated. Additionally, the gastrocnemius muscle was collected to understand histological and biochemical changes in the muscle remaining after VML. The VML injury did not alter the physical activity of mice. However, there was a noted reduction in whole-body metabolism and diurnal fluctuations between lipid and carbohydrate oxidation were also reduced, largely driven by lower carbohydrate utilization during active hours. Following VML, muscle-specific changes indicate a decreased proportion of fast (i.e., type IIb and IIx) and a greater proportion of slow (i.e., type I and IIa) fibers. However, there were minimal changes in the capillarity and metabolic biochemical activity properties of the gastrocnemius muscle, suggesting a miss-match in capacity to support the physiologic needs of the fibers. These novel findings indicate that following VML, independent of changes in physical activity, there is whole-body diurnal metabolic inflexibility. Supporting future investigations into the chronic and overlooked co-morbidities of VML injury.

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Section: Discussionmentioning

confidence: 99%

Independent of physical activity, volumetric muscle loss injury in a murine model impairs whole-body metabolism

et al. 2021

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“…to obtain a new sequence { } t y to smooth the original sequence. 4 This is the moving average method. The mathematical expression is…”

Section: Moving Average Analysismentioning

confidence: 99%

Rehabilitation Therapy With Insulin-Like Growth Factor After Acute Skeletal Muscle Injury

Wang¹,

Wang²

2021

Rev Bras Med Esporte

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Introduction Skeletal muscle injuries account for 10% to 50% of treadmill sports injuries. Insulin-like growth factor (IGF) is a family of polypeptides with both insulin-like anabolic and growth-promoting effects. Sports play a vital role in the recovery of skeletal muscle injuries. Objective The paper analyzes the ability of insulin-like growth factor 1 (IGF-1) to repair skeletal muscle injury caused by treadmill exercise. Method We injected drugs under the wound after exercise-induced injury in rats. The control group was injected with saline, and the experimental group was injected with an insulin-like growth factor. We conduct histological and electron microscopic structural analysis of rats, Results: After an injury, the experimental group formed a basal lamina protective film earlier than the control group, activated myoblasts, formed myofilaments, formed myotubes, and fused into muscle fibers earlier than the control group. The healing quality was also better. The experimental group was endogenous. The mRNA content of sex IGF-1 and IGF-2 both increased earlier than the control group. Conclusion Local injection of exogenous insulin-like growth factor-1 can stimulate the proliferation of myoblasts and accelerate the post-traumatic repair process of skeletal muscle caused by treadmill sports. Level of evidence II; Therapeutic studies - investigation of treatment results.

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“…The characteristics of physical therapy implemented are variable, depending on the type and severity of the injury, the patient's deficits, goals of therapy, resources, as well as the clinician's expertise. Generally, physical therapy has been proved to improve functional outcomes following most musculoskeletal injuries 8 .…”

Section: Rehabilitation: Key Principlesmentioning

confidence: 99%

PRINCIPLE OF REHABILITATION & COMPLICATION PREVENTION AFTER MUSCULOSKELETAL TRAUMA

Utomo

Akbar²

2021

JMJ

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Rehabilitation plays a major role to maximize outcome and prevent complications following musculoskeletal trauma and its interventions. It is reported in several studies that mortality risk in patients not receiving rehabilitation was higher compared with patients who received one. The key principles include adequate pain management, anti-infection measures, early ambulation and physical therapy, establishing proper milestones and goals, well-communicated multi-disciplinary approach, and the establishment of standardized and personalized treatment protocol. Early mobilization is supported, as long as wound healing has been taken into consideration. Holistic approach to ensure both physical and psychosocial well-being is recommended, along with special care for geriatric and paediatric populations. Furthermore, alternative medicines such as acupuncture and meditation are currently gaining popularity and subsequently advocated as adjunct therapies.

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Musculoskeletal Regeneration, Rehabilitation, and Plasticity Following Traumatic Injury

Cited by 33 publications

References 107 publications

Independent of physical activity, volumetric muscle loss injury in a murine model impairs whole-body metabolism

Independent of physical activity, volumetric muscle loss injury in a murine model impairs whole-body metabolism

Rehabilitation Therapy With Insulin-Like Growth Factor After Acute Skeletal Muscle Injury

PRINCIPLE OF REHABILITATION & COMPLICATION PREVENTION AFTER MUSCULOSKELETAL TRAUMA

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