Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis

Lu, Changbo; Liu, Pengfei; Zhou, Yongsheng; Meng, Fan-Cheng; Qiao, Tianyun; Yang, Xuan; Li, Xu-Yang; Xue, Qingyun; Xu, Hui; Liu, Ya; Han, Yong; Zhang, Yang

doi:10.1155/2020/8842110

Cited by 14 publications

(16 citation statements)

References 52 publications

(18 reference statements)

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“…During the menopause transition, women are predisposed to experience musculoskeletal pain [ 36 ], which is associated with decreased physical activity and mobility. As for the psychological factors, depression, but not anxiety, has been previously related to poorer functional mobility and described in women aged 60 years and over [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Menopausal Symptoms, Postural Balance, and Functional Mobility in Middle-Aged Postmenopausal Women

et al. 2021

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The aim of the present study was to determine the associations between the severity of the menopausal symptoms and postural balance and functional mobility in middle-aged postmenopausal women. A cross-sectional study was performed (171 participants, 57.18 ± 4.68 years). Severity of the menopausal symptoms (on the Menopause Rating Scale), postural balance (stabilometric platform) with eyes open and closed, and functional mobility (timed up and go test) were determined. A multivariate linear regression was performed, with body mass index, waist to hip ratio, age and fall history as possible confounders. Our findings showed that a greater severity of the menopausal symptoms at a psychological level was associated, under both eyes open and closed conditions, with worse postural control assessed by the length of the stabilogram (adjusted R2 = 0.093 and 0.91, respectively), the anteroposterior center of pressure displacements (adjusted R2 = 0.051 and 0.031, respectively) and the center of pressure velocity (adjusted R2 = 0.065 for both conditions). Older age was related to greater mediolateral displacements of the center of pressure with eyes open and closed (adjusted R2 = 0.45 and 0.58, respectively). There were no associations between the menopausal symptoms’ severity and functional mobility. We can conclude that a greater severity of psychological menopausal symptoms was independently associated with worse postural balance in middle-aged postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Menopausal Symptoms, Postural Balance, and Functional Mobility in Middle-Aged Postmenopausal Women

et al. 2021

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“…An example of this challenge is found in a study by Lu et al [81]. Although not specifically called "myalgia" and "arthralgia," musculoskeletal pain (MSP) was identified by Lu et al as one of the most severe conditions experienced by perimenopausal women with an estimated overall prevalence of 71% [81]. Their systematic review and meta-analysis included 16 studies, published between 1997 and 2020 in 12 countries, and their conclusions support a high musculoskeletal pain prevalence among perimenopausal women.…”

Section: Epidemiology and Physiologymentioning

confidence: 97%

Section: Epidemiology and Physiologymentioning

confidence: 99%

Musculoskeletal Health in Menopause

Geier

Benham

2021

Each Woman’s Menopause: An Evidence Based Resource

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“…Many postmenopausal women suffer from chronic pain, 1 , 2 memory decline 3 and mood depression. 4 The mechanisms underlying the comorbidity of the somatosensory and cognitive/emotional deficits are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

Zhang¹,

Xiong²,

Lin³

et al. 2021

JIR

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Postmenopausal women often suffer from chronic pain, memory decline and mood depression. The mechanisms underlying the neuronal disorders are not fully understood, and effective treatment is still lacking. Methods: Oral administration of magnesium-L-threonate was tested to treat the neuronal disorders in ovariectomized and aged female mice. The pain hypersensitivity, memory function and depression-like behaviors were measured with a set of behavioral tests. Western blots, immunochemistry and in situ hybridization were used to assess molecular changes. Results: Chronic oral administration of magnesium-L-threonate substantially prevented or reversed the chronic pain and memory/emotional deficits in both ovariectomized and aged female mice. We found that phospho-p65, an active form of nuclear factor-kappaB, tumor necrosis factoralpha and interleukin-1 beta were significantly upregulated in the neurons of dorsal root ganglion, spinal dorsal horn and hippocampus in ovariectomized and aged mice. The microglia and astrocytes were activated in spinal dorsal horn and hippocampus. Calcitonin gene-related peptide, a marker for peptidergic C-fibers, was upregulated in dorsal horn, which is associated with potentiation of C-fiber-mediated synaptic transmission in the model mice. In parallel with neuroinflammation and synaptic potentiation, free Mg 2+ levels in plasma, cerebrospinal fluid and in dorsal root ganglion neurons were significantly reduced. Oral magnesium-L-threonate normalized the neuroinflammation, synaptic potentiation and Mg 2+ deficiency, but did not affect the estrogen decline in ovariectomized and aged mice. Furthermore, in cultured dorsal root ganglion neurons, estrogen at physiological concentration elevated intracellular Mg 2+ , and downregulated phospho-p65, tumor necrosis factor-alpha and interleukin-1 beta exclusively in the presence of extracellular Mg 2+ . Conclusion: Estrogen decline in menopause may cause neuroinflammation by reducing intracellular Mg 2+ in neurons, leading to chronic pain, memory/emotional deficits. Supplement Mg 2+ by oral magnesium-L-threonate may be a novel approach for treating menopause-related neuronal disorders.

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Musculoskeletal Pain during the Menopausal Transition: A Systematic Review and Meta-Analysis

Cited by 14 publications

References 52 publications

Menopausal Symptoms, Postural Balance, and Functional Mobility in Middle-Aged Postmenopausal Women

Menopausal Symptoms, Postural Balance, and Functional Mobility in Middle-Aged Postmenopausal Women

Musculoskeletal Health in Menopause

The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice

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