Musculoskeletal Oncology:Advances in Cytogenetics and Molecular Genetics and their Clinical Implications

Orthopaedics

“…Identifying subcellular anomalies also clarifies aetiological mechanisms and helps to plan strategies for treatment and genetic counselling. Many sarcomas also display characteristic cytogenetic abnormalities 1 with prognostic and tumorigenic significance. Future genetic studies of musculoskeletal tumours are likely to define subsets of patients who are good and poor responders to therapy, as well as identifying the genes responsible in many syndromes, dysplasias and cancers 2 …”