Musculoskeletal Manifestations Observed in Patients Diagnosed With Chikungunya Virus in 2 Municipalities of the Brazilian Amazon Region

Abstract

Background Chikungunya virus fever is an emerging disease that is rapidly spreading and becoming a global public health issue because of its clinical manifestations that cause physical limitations and high rates of chronification. No studies have characterized musculoskeletal manifestations in Brazilian patients with chikungunya. Objective To describe the musculoskeletal manifestations of patients with chikungunya infection in municipalities of the Brazilian Amazon region. Methods This study was an observational, descriptive, and analytical study conducted from March to May 2018. The gender, age, time of infection, clinical manifestations reported during the acute phase, and results of a physical examination of the musculoskeletal system were collected. Results The medical records of 63 patients with a laboratory confirmation of chikungunya virus fever were analyzed. Eighty-three percent of these patients were women, with a mean age of 50.6 ± 14.5 years and 3.3 ± 3.1 months of infection. The main clinical manifestations reported during the acute phase were arthralgia (100%), fever (91%), and exanthema (65%). The physical examination revealed that the main joints affected by arthralgia resulted in a polyarticular (57%, 5–10 joints) and symmetrical pattern (62%) that mainly affected the ankles (53%) and knees (51%). Regarding arthritis, the most frequently affected area was the wrist (42%), with an oligoarticular pattern (42%, 2–4 joints). Conclusions In general, the clinical manifestations described in the Brazilian Amazon population are similar to those reported in publications from other countries; however, the main arthritis pattern identified is oligoarticular, with a predominance of the wrist. Moreover, the chronicity rate is 48%.

Prevalência de condições musculoesqueléticas e fatores associados à dor articular em indivíduos com Chikungunya no Amapá, Brasil: um estudo transversal

“…Nossos resultados se assemelham aos obtidos por Hayd et al [11] que em Roraima, também na Amazônia, observaram a prevalência de febre (98%); dor articular (98%); dor de cabeça (93%) e mialgia em 85% dos casos analisados. Cardoso Pereira et al [7], conduzindo um estudo observacional em três cidades da região Amazônica, no estado do Pará, apontaram a artralgia como a principal queixa dos pacientes com CHIK na fase aguda, presente em 100% dos casos avaliados, maior inclusive que a febre 91%, e a mialgia referida por 29% dos indivíduos avaliados.…”

“…No contexto da região Amazônica, em particular o estado do Amapá, identificado como porta de entrada do VCHIK e que sustenta surtos da doença [7][8][9], apresenta carências socioeconômicas e estruturais profundas relacionadas à saúde, além disso, a região oferece condições climáticas favoráveis à proliferação do mosquito transmissor, como altas temperaturas médias, alto índice pluviométrico e de umidade. Fisioterapia Brasil 2023;24(6):826-836…”

Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection

“…Our group has recently described the characteristics of 63 CKV patients from Brazilian Amazon, which the main arthritis pattern identified was oligoarticular, with a predominance of ankles and knees, and also with a chronicity rate of 48%, however no autoantibody was studied. Until now, we do not have any knowledge of studies in which several autoantibodies profile in CKV were systematically analised [11].…”