Musculoskeletal disorders in diabetes mellitus: an update

Arkkila, Perttu; Gautier, Jean‐François

doi:10.1016/j.berh.2003.11.001

Cited by 163 publications

(157 citation statements)

References 122 publications

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“…Compared to reports concerning diabetes-related musculoskeletal manifestations in adults, predominantly osteoporosis and increased fracture risk, upper limb musculoskeletal abnormalities (shoulder and hand), limited joint mobility, septic arthritis, carpal tunnel syndrome, trigger finger, and Dupuytren's contracture [7][8][9][10]13], we found a range of joint, …”

Section: Discussioncontrasting

confidence: 86%

“…In this pediatric population, we have previously found that the two types of diabetes are sometimes misclassified or not specified, leading to similar patterns of complications, e.g., neuropathy, diabetic ketoacidosis, etc [11]. Furthermore, previous studies have found the patterns of musculoskeletal manifestations of DM to be very similar between the two types [7,8] …”

Section: Study Population and Datamentioning

confidence: 86%

“…Previous studies of DM in adults have identified limited joint mobility, stiff hand syndrome, diabetic muscular infarction, Page 2 of 8 and neuropathy, flexor tenosynovitis, and carpal tunnel syndrome as its predominant musculoskeletal manifestations [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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2016

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Section: Discussioncontrasting

confidence: 86%

Section: Study Population and Datamentioning

confidence: 86%

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2016

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“…[9] Even though the exact pathophysiology of most of these musculoskeletal disorders remains obscure, however, connective tissue disorders, neuropathy or vasculopathy may have a synergistic effect on the increased incidence of musculoskeletal disorders in DM. [10] According to Crispin and Alcocer, prolonged hyperglycemia in uncontrolled diabetic patients results in collagen glycosylation. Glycosylated collagen is less soluble, offers increased resistance to collagenases and accumulates in connective tissue, which not only alters the extra cellular matrix structure and function but also affects cell viability.…”

Section: Discussionmentioning

confidence: 99%

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

Bhat

Dhar

Dar

et al. 2016

IJHS

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Objectives: Diabetes mellitus (DM), is affecting an ever increasing number of people worldwide. Diabetes is associated with several musculoskeletal manifestations. These may involve, the upper as well as the lower limb. We conducted this study to find out the prevalence of musculoskeletal problems in type 2 diabetics in the Kashmiri population. Methodology:The study was conducted on 403 patients with diabetes and 300 controls. All patients underwent screening for any musculoskeletal abnormalities. The patients with musculoskeletal abnormalities were further assessed to find the exact diagnosis according to predefined criteria. Results:The hand was involved in 80 patients [19.8%] in the diabetic group and 15 (5%) patients of the control group. The elbow was affected in 56 patients [14%] in the diabetic group and 24 patients [5.9%] in the non-diabetic group. The shoulder involvement was diagnosed in 61 patients [15%] on the diabetic cohort and 15 patients in the non-diabetic cohort. All the upper limb figures showed a statistically significant difference i.e. P value <0.05. Conclusion:The prevalence of musculoskeletal complications in type 2 diabetics in Kashmir is quite high.

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“…9 This disease affects connective tissues in many ways and causes different alterations in periarticular and musculoskeletal system. 10 Type 2-diabetes is frequently reported co-occurring disease in elderly patient with knee osteoarthritis. Singh et al reported that there was around 55% of knee osteoarthritis patients of over 65 years old having hypertension and 13% of them showing Type 2 Diabetes Mellitus.…”

Section: Introductionmentioning

confidence: 99%

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

Shrivastava

Singh

Chandel³

et al. 2017

Int J Res Med Sci

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INTRODUCTIONKnee pain is one of the most common musculoskeletal complaints that bring people to their physician and the most common cause of knee pain is osteoarthritis. 1 Especially in females, knee osteoarthritis is the major cause of mobility impairment.2,3 Nearly, 45% of women over the age of 65 years have symptomatic findings of knee osteoarthritis while radiological evidence is found in 70% of those over 65 years.2-4 In India, average menopausal age in women is 46.3 years as compared to 54 years in western countries. 5,6 This predisposes Indian women at higher risk of developing osteoarthritis in earlier age as compared to their western counterparts. It could be due to loss of estrogen especially close to menopausal years at this time. 7,8ABSTRACT Background: Knee osteoarthritis is the most common form of joint disorder and a leading cause of pain and functional disability among elderly female population. Type 2-diabetes is frequently reported comorbidity in elderly female patients with knee osteoarthritis. VCAM-1 is emerging as a strong and independent predictor for severe osteoarthritis. VCAM-1 is an inducible cell surface sialo glycoprotein and mediates heterotypic cellular aggregation. Therefore, the aim of this study is to assess the role of soluble vascular cell adhesion molecule-1 at the onset of knee osteoarthritis among type 2 diabetic postmenopausal women. Methods: The present study includes 100 type 2-diabetic female subjects of age above 50 years as cases and 100 normal healthy female age matched individuals as controls. Osteoarthritis of knee was ascertained using the American college of rheumatology classification criteria. Serum soluble VCAM-1 concentration was measured by ELISA method in all 200 subjects. Biochemical parameters-Fasting blood sugar and lipid profile were measured using Mind ray BS-400 and HbA1c was measured by turbidimetric immunoassay method. Statistical analysis was made by student independent sample t-test. Correlation was determined by using spearman's rank correlation coefficient. Results: Serum level of soluble VCAM-1 was found statistically highly significant (p<0.001) in type 2 diabetic postmenopausal women having early stage of knee osteoarthritis as compared to control healthy subjects. The mean levels of fasting blood sugar, HbA1c, total cholesterol, TG, LDL-C and VLDL-C were also found significantly increased while HDL-C was found significantly decreased in cases as compared to controls. Conclusions: The increased level of soluble VCAM-1 in type 2 diabetic subjects shows active inflammation or cartilage damage. Therefore, it can be used as an early biomarker for osteoarthritis among type 2 diabetic postmenopausal women.

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Musculoskeletal disorders in diabetes mellitus: an update

Cited by 163 publications

References 122 publications

Untitled

Untitled

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

Status of soluble vascular cell adhesion molecule-1 in knee osteoarthritis among type 2-diabetic postmenopausal women

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