Musculoskeletal complications of haematological disease

Abstract

Rheumatological manifestations complicate many benign and malignant blood disorders. Significant advances in haematology, with improved diagnostic techniques and newer musculoskeletal imaging, have occurred in the past two decades. This review focuses on the interrelationship between the major haematological diseases (haemochromatosis, haemophilia, sickle cell disease, thalassaemia, leukaemia, lymphoma, myelodysplastic syndromes, multiple myeloma and cryoglobulinaemia) and rheumatic manifestations.

Recommendations from the ICM-VTE: General

“…Hemophilia is an inherited bleeding disorder and has two main types, i.e., hemophilia A that stems from Factor VIII deficiency and hemophilia B that stems from Factor IX deficiency. Many (90%) of the patients with hemophilia develop hemophilic arthropathy before the age of 30 due to recurrent hemarthroses 1485,1486 . Despite the high rate of surgical complications including infection, the number of patients undergoing total joint arthroplasty (TJA) has been rising with increased availability of factor replacement therapy 1481,1487,1488 .…”

Acute Promyelocytic Leukemia Masquerading as Sero-negative Polyarthritis: Case Report

“…Musculoskeletal presentation has been reported in many malignancies. 9 The most common presentations are myalgia, arthralgia, arthritis, osteolytic bony lesions, and spontaneous fractures. 9 Leukemic arthritis is defined as joint pain and swelling in a diagnosed case of leukemia when other causes of arthritis have been excluded.…”

“…9 The most common presentations are myalgia, arthralgia, arthritis, osteolytic bony lesions, and spontaneous fractures. 9 Leukemic arthritis is defined as joint pain and swelling in a diagnosed case of leukemia when other causes of arthritis have been excluded. 10 It is reported to occur in around 12 to 65% cases of acute leukemia in children, whereas in adults the reported prevalence is between 4 and 13%.…”

A study of patient‐reported pain during bone marrow aspiration and biopsy using local anesthesia alone compared with local anesthesia with intravenous midazolam coadministration at a tertiary academic hospital in South Africa

“…This study found no statistically significant correlation between the patient's diagnosis and pain, which is consistent with the findings of Gendron et al 20 Bone pain is part of the disease process in almost all multiple myeloma, in some acute leukemia and in other hematological conditions. 24 , 25 We, therefore, aimed to investigate the role of the underlying disease in the pain experience by our participants.…”