Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients

Jackson, Taylor; Mostoufi‐Moab, Sogol; Hill‐Kayser, Christine; Balamuth, Naomi; Arkader, Alexandre

doi:10.1002/pbc.26905

Cited by 12 publications

(11 citation statements)

References 83 publications

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“…Avascular necrosis or osteonecrosis (ON) is the most common and debilitating sequelae of conditioning regimens (following total body irradiation) for allogeneic HSC transplantation which appears in 4-19% of HSCT survivors [16]. Long, continuous exposure to corticosteroids during delayed intensification chemotherapy plays a pivotal role in the development of ON [17].…”

Section: Introductionmentioning

confidence: 99%

The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases

Kuçi

Jordan

Wehner

et al. 2020

Cells

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As the biology of mesenchymal stromal cells (MSCs) in patients with non-malignant hematological diseases (NMHD) is poorly understood, in the current study we performed a basic characterization of the phenotype and functional activity of NMHD-MSCs. Bone marrow (BM) of patients with thalassemia major (TM) possessed a significantly higher number of nucleated cells (BM-MNCs)/mL BM than healthy donors (P < 0.0001), which however did not result in a higher number of colony forming units-fibroblast (CFU-F) per milliliter BM. In contrast, from 1 × 106 BM-MNCs of patients with sickle cell disease (SCD) were generated significantly more CFU-Fs than from TM-BM-MNCs (P < 0.013) and control group (P < 0.02). In addition, NMHD-MSCs expressed significantly lower levels of CD146 molecule, demonstrated an equal proliferation potential and differentiated along three lineages (osteoblasts, chondrocytes and adipocytes) as healthy donors’ MSCs, with exception of TM-MSCs which differentiated weakly in adipocytes. In contrast to other NMHD-MSCs and healthy donors’ MSCs, TM-MSCs demonstrated an impaired in vitro immunosuppressive potential, either. Noteworthy, the majority of the immunosuppressive effect of NMHD-MSCs was mediated through prostaglandin-E2 (PGE2), because indomethacin (an inhibitor of PGE2 synthesis) was able to significantly reverse this effect. Our results indicate therefore that NMHD-MSCs, except TM-MSCs, may be used as an autologous cell-based therapy for post-transplant complications such as graft failure, graft-versus-host disease (GvHD) and osteonecrosis.

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Section: Introductionmentioning

confidence: 99%

The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases

Kuçi

Jordan

Wehner

et al. 2020

Cells

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“…Growth disturbances such as decreased size of the bone irradiated, growth arrest lines, retardation of growth, angular deformities, premature physeal fusion, undertubulation, widening of the physis and joint space, metaphyseal changes mimicking rickets, slipped epiphysis, osteochondromas, and scoliosis may be seen. 17 Some of these changes may occur months after radiotherapy. Growth potential in the epiphysis is already fatally compromised at a dose of 12 Gy.…”

Section: Radiotherapymentioning

confidence: 99%

“…Thus collateral damage may occur in nearby critical structures such as skin, neurovascular bundles, subchondral bone, and cartilage (►Fig. 17). Also, fractures may occur after RFA involving cortical bone.…”

Section: Surgery and Soft Tissuesmentioning

confidence: 99%

Therapy-Related Imaging Findings in Patients with Sarcoma

Bloem

Vriens

Krol

et al. 2020

Semin Musculoskelet Radiol

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Knowledge of imaging findings related to therapy administered to patients with sarcoma is pivotal in selecting appropriate care for these patients. Imaging studies are performed as surveillance in asymptomatic patients or because symptoms, including anxiety, develop. In addition to detection of recurrent disease and assessment of response to therapy, diagnosis of conditions related to therapy that may or may not need treatment has a marked positive impact on quality of life. The purpose of this review is to assist radiologists, nuclear physicians, and others clinicians involved in the diagnosis and treatment of these patients in recognizing imaging findings related to therapy and not to activity of the previously treated sarcoma. Imaging findings are time dependent and often specific in relation to therapy given.

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“…Long-term issues, such as cognitive dysfunction, cardiovascular disease, immune disruption, tissue remodeling, metabolic disorders and second malignant tumors, continue to haunt cancer survivors long after treatment has discontinued, [38][39][40][41][42][43][44][45][46][47] especially those treated at a younger age. [48][49][50][51][52][53][54][55][56][57] Unfortunately, with the majority of radiation-induced late outcomes, once such effects become symptomatic, mitigation and/or treatment strategies have proven to have limited efficacy. As a result, radiation oncologists have continued to explore treatment options, e.g.…”

Section: Normal Tissue Damage Modelsbiological and Mathematicalmentioning

confidence: 99%

Normal tissue damage: its importance, history and challenges for the future

Williams

Newhauser

2018

The British Journal of Radiology

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Sir Oliver Scott, a philanthropist and radiation biologist and, therefore, the epitome of a gentleman and a scholar, was an early Director of the BECC Radiobiology Research Unit at Mount Vernon. His tenure preceded that of Jack Fowler, with both contributing to basic, translational and clinical thought and application in radiation across the globe. With respect to this review, Fowler's name in particular has remained synonymous with the use of models, both animal and mathematical, that assess and quantify the biological mechanisms that underlie radiation-associated normal tissue toxicities. An understanding of these effects is critical to the optimal use of radiation therapy in the clinic; however, the role that basic sciences play in clinical practice has been undergoing considerable change in recent years, particularly in the USA, where there has been a growing emphasis on engineering and imaging to improve radiation delivery, with empirical observations of clinical outcome taking the place of models underpinned by evidence from basic science experiments. In honour of Scott and Fowler's work, we have taken this opportunity to review how our respective fields of radiation biology and radiation physics have intertwined over the years, affecting the clinical use of radiation with respect to normal tissue outcomes. We discuss the past and current achievements, with the hope of encouraging a revived interest in physics and biology as they relate to radiation oncology practice, since, like Scott and Fowler, we share the goal of improving the future outlook for cancer patients.

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Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients

Cited by 12 publications

References 83 publications

The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases

The Phenotype and Functional Activity of Mesenchymal Stromal Cells in Pediatric Patients with Non-Malignant Hematological Diseases

Therapy-Related Imaging Findings in Patients with Sarcoma

Normal tissue damage: its importance, history and challenges for the future

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