Musculoskeletal Abnormalities Caused by Cystic Fibrosis

Abstract

Cystic Fibrosis (CF) can affect all organs of the human body including the musculoskeletal system. Although the musculoskeletal aspects of CF are less commonly studied, fractures (predominantly spinal), muscle injuries, and joint pain are more commonly seen in the CF population compared to the general public due to their lower bone mineral density, dysfunctional skeletal muscle, and elevated levels of pro-inflammatory cytokines. Additionally, due to elevated levels of inflammation in the CF population diagnosis of musculoskeletal injuries can be difficult to pinpoint. As treatment for CF evolves, an increased understanding of how CF affects the musculoskeletal system is imperative. We will discuss the orthopedic aspects of CF and provide potential insights into the future direction of orthopedic care in the CF population.