Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

Dolan, Eimear; Artioli, Guilherme Giannini; Pereira, Rosa Maria Rodrigues; Gualano, Bruno

doi:10.3390/biom9110642

Cited by 35 publications

(28 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has also been observed that plasma and muscle creatine levels are lower in those who eat vegetarian/low-meat diets [348] and older populations [349], thus highlighting the importance of supplementing creatine in these groups. Creatine's safety and cost-effectiveness make it a potentially useful supplement, to take in conjunction with a (home based) RE protocol, for the prevention of muscle atrophy and sarcopenia [350].…”

Section: Creatinementioning

confidence: 99%

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

et al. 2020

View full text Add to dashboard Cite

The COVID-19 pandemic is an extraordinary global emergency that has led to the implementation of unprecedented measures in order to stem the spread of the infection. Internationally, governments are enforcing measures such as travel bans, quarantine, isolation, and social distancing leading to an extended period of time at home. This has resulted in reductions in physical activity and changes in dietary intakes that have the potential to accelerate sarcopenia, a deterioration of muscle mass and function (more likely in older populations), as well as increases in body fat. These changes in body composition are associated with a number of chronic, lifestyle diseases including cardiovascular disease (CVD), diabetes, osteoporosis, frailty, cognitive decline, and depression. Furthermore, CVD, diabetes, and elevated body fat are associated with greater risk of COVID-19 infection and more severe symptomology, underscoring the importance of avoiding the development of such morbidities. Here we review mechanisms of sarcopenia and their relation to the current data on the effects of COVID-19 confinement on physical activity, dietary habits, sleep, and stress as well as extended bed rest due to COVID-19 hospitalization. The potential of these factors to lead to an increased likelihood of muscle loss and chronic disease will be discussed. By offering a number of home-based strategies including resistance exercise, higher protein intakes and supplementation, we can potentially guide public health authorities to avoid a lifestyle disease and rehabilitation crisis post-COVID-19. Such strategies may also serve as useful preventative measures for reducing the likelihood of sarcopenia in general and in the event of future periods of isolation.

show abstract

Section: Creatinementioning

confidence: 99%

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The ergogenic effects of creatine supplementation are well documented, with evidence supporting its efficacy in increasing muscle strength, lean mass, and exercise performance/muscle function, particularly when combined with exercise in different populations, from athletes to a wide spectrum of patient populations [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Creatine Supplementation and Brain Health

et al. 2021

View full text Add to dashboard Cite

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.

show abstract

“…Among the strategies studied for the management and prevention of sarcopenia, only physical exercise [20,21] has shown significant positive effects. A potential role for Creatine and Leucine supplementation has been suggested but remains yet to be proven [22,23]. Thus, further welldesigned ad-hoc studies are needed [24], even if it might be difficult to conduct them in patients with advanced liver disease, older age and significant extrahepatic comorbidities who are usually the subgroups receiving TAE.…”

Section: Plos Onementioning

confidence: 99%

Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma

et al. 2020

View full text Add to dashboard Cite

Sarcopenia has been associated with lower overall survival in patients with cirrhosis and hepatocellular carcinoma (HCC) undergoing surgical resection, TACE, TARE, or transplantation. This monocentric study evaluated the prognostic significance of sarcopenia in patients affected by HCC who received bland transarterial embolization (TAE) therapy, by analyzing its impact on survival and treatment-related complications. All consecutive patients who underwent the 1st TAE between March 1st 2011 and July 1st 2019 in our Institution were retrospectively studied. To evaluate sarcopenia, the skeletal muscle index (SMI) was calculated by normalizing the cross-sectional muscle area at the level of L3 on an abdominal CT scan prior to embolization (cm2) by patient height (m2). SMI cutoff values for sarcopenia were considered � 39 cm2/m2 for women and �55 cm2/m2 for men. Data about age, gender, body mass index (BMI), underlying liver disease, liver function, MELD score, Child-Pugh score, multifocal disease, performance status, previous interventions, length of stay (LOS), complications after the procedure, readmission rate within 30 days, survival time from TAE and total number and type of TAE received following the first procedure were collected. From 2011 to 2019, 142 consecutive patients underwent 305 TAEs. Observation time ranged from 1.4 to 100.5 months (median 20.1 SD = 22). Sarcopenia at baseline was present in 121 (85%) patients. Overall 87 (61.2%) patients died during followup with survival rates at 1-, 2-, 3-, 4-, and 5-year of 71%, 41%, 22%, 16% and 11% respectively. After multivariate analysis sarcopenia (HR = 2.22, p = 0.046), previous ablation/ PLOS ONE |

show abstract

Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

Cited by 35 publications

References 78 publications

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss

Creatine Supplementation and Brain Health

Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma

Contact Info

Product

Resources

About