Muscular and mitochondrial effects of long-term fluoxetine treatment in mice, combined with physical endurance exercise on treadmill

Tutakhail, Abdulkarim; Nazari, Qand Agha; Khabil, Sarah; Gardier, Alain M.; François, Clément

doi:10.1016/j.lfs.2019.05.064

Cited by 12 publications

(14 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, exercise significantly decreased ROS levels in both fluoxetine and non-fluoxetine groups, with this reduction higher in the fluoxetine group ( 375 ). Post-hoc analysis of a trial of a mitochondrial combination therapy found the greatest benefits in those with the highest levels of physical activity ( 376 ). There is a meta-analytic level of evidence from RCT's that exercise has antidepressant effects.…”

Section: Effects Of Pharmacotherapy On Mitochondrial Functionsmentioning

confidence: 99%

The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

et al. 2021

View full text Add to dashboard Cite

Mitochondria are cellular organelles involved in several biological processes, especially in energy production. Several studies have found a relationship between mitochondrial dysfunction and mood disorders, such as major depressive disorder and bipolar disorder. Impairments in energy production are found in these disorders together with higher levels of oxidative stress. Recently, many agents capable of enhancing antioxidant defenses or mitochondrial functioning have been studied for the treatment of mood disorders as adjuvant therapy to current pharmacological treatments. A better knowledge of mitochondrial physiology and pathophysiology might allow the identification of new therapeutic targets and the development and study of novel effective therapies to treat these specific mitochondrial impairments. This could be especially beneficial for treatment-resistant patients. In this article, we provide a focused narrative review of the currently available evidence supporting the involvement of mitochondrial dysfunction in mood disorders, the effects of current therapies on mitochondrial functions, and novel targeted therapies acting on mitochondrial pathways that might be useful for the treatment of mood disorders.

show abstract

Section: Effects Of Pharmacotherapy On Mitochondrial Functionsmentioning

confidence: 99%

The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…14 Finally, recent ndings suggest that uoxetine may enhance cellular antioxidant capacity by tuning mitochondrial redox parameters and through the upregulation of thioredoxin (Trx), a dithiol-disulde oxidoreductase that can facilitate H 2 O 2 scavenging. 20 Nevertheless, the indirect antioxidant role that uoxetine plays in neuroprotection is still debated. Particularly, Dalmizrak et al reported that long-term use of uoxetine may be connected with glutathione reductase (GR) deciency, 21 while Byeon et al pointed out that SSRIs might mediate oxidative stress in aquatic invertebrates.…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine scaffold to design tandem molecular antioxidants and green catalysts

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As recently summarized [ 13 ], data suggest that SSRIs may have antioxidant effects and lower lipid peroxidation in humans. Experimental studies indicate that this effect could be mediated by a reduction of mitochondrial ROS production [ 14 – 16 ]. To our knowledge, only two intervention studies including 45 [ 17 ] and 22 [ 18 ] participants have investigated whether treatment with SSRIs affects DNA damage from oxidation.…”

Section: Introductionmentioning

confidence: 99%

Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

et al. 2022

View full text Add to dashboard Cite

Previous studies have indicated that antidepressants that inhibit the serotonin transporter reduces oxidative stress. DNA and RNA damage from oxidation is involved in aging and a range of age-related pathophysiological processes. Here, we studied the urinary excretion of markers of DNA and RNA damage from oxidation, 8-oxodG and 8-oxoGuo, respectively, in the NeuroPharm cohort of 100 drug-free patients with unipolar depression and in 856 non-psychiatric community controls. Patients were subsequently treated for 8 weeks with escitalopram in flexible doses of 5–20 mg; seven of these switched to duloxetine by week 4, as allowed by the protocol. At week 8, 82 patients were followed up clinically and with measurements of 8-oxodG/8-oxoGuo. Contextual data were collected in patients, including markers of cortisol excretion and low-grade inflammation. The intervention was associated with a substantial reduction in both 8-oxodG/8-oxoGuo excretion (25% and 10%, respectively). The change was not significantly correlated to measures of clinical improvement. Both markers were strongly and negatively correlated to cortisol, as measured by the area under the curve for the full-day salivary cortisol excretion. Surprisingly, patients had similar levels of 8-oxodG excretion and lower levels of 8-oxoGuo excretion at baseline compared to the controls. We conclude that intervention with serotonin reuptake inhibitors in unipolar depression is associated with a reduction in systemic DNA and RNA damage from oxidation. To our knowledge, this to date the largest intervention study to characterize this phenomenon, and the first to include a marker of RNA oxidation.

show abstract

Muscular and mitochondrial effects of long-term fluoxetine treatment in mice, combined with physical endurance exercise on treadmill

Cited by 12 publications

References 49 publications

The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

Fluoxetine scaffold to design tandem molecular antioxidants and green catalysts

Systemic DNA and RNA damage from oxidation after serotonergic treatment of unipolar depression

Contact Info

Product

Resources

About