Muscovy ducks infected with velogenic Newcastle disease virus (genotype VIId) act as carriers to infect in-contact chickens

Elbestawy, Ahmed R.; Ellakany, Hany F.; El-Hamid, Hatem S. Abd; Zedan, Rasha E.; Gado, Ahmed R.; Sedeik, Mahmoud E.; El‐Hack, Mohamed E. Abd; Saadeldin, Islam M.; Alowaimer, Abdullah N.; Swelum, Ayman A.

doi:10.3382/ps/pez276

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…As waterfowls (i.e. domestic ducks and geese) do not exhibit illness or die when infected with virulent viruses that specifically infect chickens such as highly pathogenic avian influenza or genotype VIId NDVs, they often act as an effective viral carrier and transmit viruses to other birds (Elbestawy et al, 2019;Kang et al, 2018;Kwon et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Phylodynamic analyses of class I Newcastle disease virus isolated in China

Chen

Song

Liu

et al. 2020

Transbound Emerg Dis

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Newcastle disease (ND) is an infectious disease that affects both wild and domestic birds worldwide, causing significant losses to the poultry industry (Swayne, 2013). The economic burden of ND in poultry is attributed not only to the mortality and depopulation of stock but also to the preventative measures and restriction of poultry trade during and immediately after outbreaks (Hicks, Dimitrov, Afonso, Ramey, & Bahl, 2019;Leslie, 2000). ND is caused by Newcastle disease virus (NDV), a member of the genus Orthoavulavirus of the family Paramyxoviridae and the subfamily Avulavirinae, whose genome is a single-stranded, negative-sense RNA, coding for six structural proteins, namely nucleoprotein (NP), phosphoprotein (P), matrix protein (M), fusion protein (F), hemagglutinin-neuraminidase (HN) and large protein (L), and two non-structural proteins, V and W (Alexander, 2000).Based on the completed F gene sequence (1662 nt), NDV is phylogenetically divided into two groups with a single serotype,

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Section: Discussionmentioning

confidence: 99%

Phylodynamic analyses of class I Newcastle disease virus isolated in China

Chen

Song

Liu

et al. 2020

Transbound Emerg Dis

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“…From these results, it could be concluded that free-range pigeons can be considered as an efficient reservoir for NDV-VIId to opened-house raised broilers. A similar experiment by Elbestawy et al [38] proved that Muscovy ducks infected with the velogenic (AOAV-1) NDV genotype VIId, by the intra-nasal route, shed the virus in their tracheas for up to 16 days PI and their in-contact infected chickens showed clear characteristic signs for NDV and 20% mortality. These in-contact chickens were still shedding the virus in their oropharyngeal and cloacal excreta for up to 11 days post-exposure to the infected ducks.…”

Section: Discussionmentioning

confidence: 71%

Sequence analysis and pathogenicity of Avian Orthoavulavirus 1 strains isolated from poultry flocks during 2015–2019

et al. 2020

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Background: Newcastle disease (ND) causes severe economic losses in poultry industry worldwide. Egyptian poultry industry suffered from severe economic losses since the isolation of Velogenic Newcastle disease virus (vNDV) genotype VIId in 2011 and up till now despite the use of different vaccination programs. So, this study aimed to isolate and characterize the vNDV from a total of 120 poultry flocks from ten provinces in the Egyptian Delta region with a history of respiratory manifestation, high mortalities or a decrease in egg production between 2015 and 2019. Seventy-three samples' allantoic fluid (73/120, 60.8%) were positive for hemagglutination with chicken RBCs. These samples were submitted to molecular examination using qRT-PCR specific primers for AOAV-1, highly pathogenic avian influenza (HPAI-H5), low pathogenic avian influenza (LPAI-H9) and infectious bronchitis virus (IBV). Results: Fifty samples (50/120: 41.6%) were confirmed positive for AOAV-1, based on genetic analysis of matrix and fusion protein. The co-infection rate of other respiratory viral diseases examined was 1.6, 14.1, and 4.1%, for HPAI-H5, LPAI-H9, and IBV, respectively. Biologically, the intracerebral pathogenicity index of ten selected AOAV-1 isolates ranged from 1.70 to 1.98, which indicated the velogenic nature of these isolates. All the sixteen sequenced isolates were AOAV-1 genotype VII.1.1. The full F gene sequence of six examined AOAV-1 VII.1.1 isolates contained the seven neutralizing epitopes, and the glycosylation motif of six-potential sites for N linked glycosylation at residues 85, 191, 366, 447, 471, and 541. Conclusion: It could be concluded that the high prevalence of AOAV-1 genotype VII.1.1 in the Egyptian chicken flocks despite the intensive vaccination with live and killed ND vaccines, as all the 16 isolates tested were belonged to this genotype. Homologous vaccination is badly needed to control and reduce the spread of AOAV-1 genotype VII.1.1infection in Egyptian poultry flocks.

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“…La enfermedad de Newcastle es una enfermedad viral contagiosa aguda de las aves, y es una de las más importantes enfermedades que causas considerables pérdidas económicas en la industria avícola (Wang et al, 2016;Yune & Abdela, 2017;Owoya et al, 2020a). El virus causante de esta enfermedad se agrupa en la familia Paramyxoviridae, género Avulavirus y especie virus de la enfermedad de Newcastle o Paramyxovirus aviar tipo I (APMV-1) (Mayo, 2002;Abd-El Aziz et al, 2016;Brown & Bevins, 2017;Elbestawy et al, 2019). La enfermedad de Newcastle es una infección altamente contagiosa y con frecuencia severa que existe en todo el mundo y afecta a las aves, incluidas las aves de corral domésticas (OIE, 2020).…”

Section: Introductionunclassified

“…Existe un número alto de especies aviares susceptibles al virus de la ENC que incluye las aves silvestres, acuáticas y ornamentales, las cuales contribuyen constantemente a la diseminación viral. La enfermedad se considera de distribución mundial y se reportó infecciones en más de 200 especies (Carrasco et al, 2016;Wang et al, 2016;OIE, 2018;Elbestawy et al, 2019;Owoya et al, 2020b;Zahid et al, 2020).…”

Section: Introductionunclassified

“…La magnitud de este problema a nivel mundial varía debido a la presentación de brotes recurrentes, caracterizados por alta mortalidad y otros donde solo se observan infecciones respiratorias ligeras o en algunos casos no existe evidencias clínicas de enfermedad (Alexander, 2003;Abd El Aziz et al, 2016;Elbestawy et al, 2019). Villegas (2015) destaca las afectaciones en la salud pública, en el comercio internacional de los animales y sus subproductos.…”

Section: Introductionunclassified

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Seroprevalencia Del Virus De Newcastle en Dos Granjas De Patos Pekín en La Provincia Artemisa, Cuba

Machín-León¹,

Colas-Chavez

Lazo-Pérez³

et al. 2020

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El objetivo de la investigación fue determinar la evolución histórica y los canales enzoóticos de la seroprevalencia del virus de la enfermedad de Newcastle (VENC) en dos granjas de patos Pekín de la provincia Artemisa, Cuba. Se realizó un estudio epidemiológico observacional retrospectivo de la seroprevalencia del virus, basado en el diagnóstico serológico de una serie de tiempo de cinco años. Se determinó si la época del año constituía un factor de riesgo asociado a la seroprevalencia. Fueron definidos los canales enzoóticos de la seropositividad y medias geométricas del virus. Se evidenció mayor riesgo de seroprevalencia al VENC, con incremento a medida que transcurrieron los años. Los valores de las medias geométricas de los títulos de anticuerpos contra el virus estuvieron por encima del comportamiento habitual o canal enzoótico, en zonas de alerta y epizoótica en algunos meses de la serie de tiempo analizada. La seroprevalencia resultó superior en la granja A, respecto a la granja B, lo cual estuvo condicionado a mayor cantidad de brechas sanitarias, tales como una mayor cercanía a granjas de gallinas ponedoras, carreteras y asentamientos poblacionales, así como, potencial contacto con aves migratorias.

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Muscovy ducks infected with velogenic Newcastle disease virus (genotype VIId) act as carriers to infect in-contact chickens

Cited by 16 publications

References 26 publications

Phylodynamic analyses of class I Newcastle disease virus isolated in China

Phylodynamic analyses of class I Newcastle disease virus isolated in China

Sequence analysis and pathogenicity of Avian Orthoavulavirus 1 strains isolated from poultry flocks during 2015–2019

Seroprevalencia Del Virus De Newcastle en Dos Granjas De Patos Pekín en La Provincia Artemisa, Cuba

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