Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke

Liu, Fei; Cao, Lei; Hu, Shejing; Ye, Hongxiang; Wu, Qiang; Wu, Le

doi:10.1016/j.cellimm.2023.104704

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…Muscone , the primary active constituent of musk , has been extensively employed in the management of cerebral ischemia and reperfusion injury ( HAN et al, 2022 ). Muscone exhibits the ability to enhance the expression of Arg1 and CD206 via the PPARγ pathway, thereby significantly augmenting the conversion of microglia into M2 phenotype ( REN et al, 2022 ; LIU et al, 2023 ). Additionally, it diminishes the levels of TNF-α, IL-1β, and IL-6, while up-regulating CXCL1, TGF-β, and IL-10 ( REN et al, 2022 ; LIU et al, 2023 ).…”

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

“…Muscone exhibits the ability to enhance the expression of Arg1 and CD206 via the PPARγ pathway, thereby significantly augmenting the conversion of microglia into M2 phenotype ( REN et al, 2022 ; LIU et al, 2023 ). Additionally, it diminishes the levels of TNF-α, IL-1β, and IL-6, while up-regulating CXCL1, TGF-β, and IL-10 ( REN et al, 2022 ; LIU et al, 2023 ). These effects contribute to the mitigation of inflammation and facilitation of nerve recovery at the site of cerebral infarction.…”

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

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Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

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Ischemic stroke is a prevalent clinical condition affecting the central nervous system, characterized by a high mortality and disability rate. Its incidence is progressively rising, particularly among younger individuals, posing a significant threat to human well-being. The activation and polarization of microglia, leading to pro-inflammatory and anti-inflammatory responses, are widely recognized as pivotal factors in the pathogenesis of cerebral ischemia and reperfusion injury. Traditional Chinese herbal medicines (TCHMs) boasts a rich historical background, notable efficacy, and minimal adverse effects. It exerts its effects by modulating microglia activation and polarization, suppressing inflammatory responses, and ameliorating nerve injury through the mediation of microglia and various associated pathways (such as NF-κB signaling pathway, Toll-like signaling pathway, Notch signaling pathway, AMPK signaling pathway, MAPK signaling pathway, among others). Consequently, this article focuses on microglia as a therapeutic target, reviewing relevant pathway of literature on TCHMs to mitigate neuroinflammation and mediate IS injury, while also exploring research on drug delivery of TCHMs. The ultimate goal is to provide new insights that can contribute to the clinical management of IS using TCHMs.

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Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Section: The Mechanism Of Tcmhs Intervention In Microglia and Its Rel...mentioning

confidence: 99%

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Zhang,

Xu,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation

Frederico Gava,

Jaconi De Carli,

Stork

et al. 2024

Brain Research

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Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke

Sun,

Luo,

et al. 2024

Experimental Neurology

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Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke

Cited by 8 publications

References 41 publications

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways

Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation

Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke

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