Muscle weakness in Parkinson's disease: a follow-up study

Nogaki, H; Kakinuma, Susumu; Morimatsu, Mitsunori

doi:10.1016/s1353-8020(01)00002-5

Cited by 31 publications

(24 citation statements)

References 7 publications

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“…For example, this strategy could be adopted due to the inability to generate appropriate momentum or the presence of neuromuscular deficits, which limit adequate muscular force production [26, 28]. While we did not directly measure muscular force, our findings are consistent with reports of reduced lower extremity force generation in persons with PD [29]. In aggregate, the cross-sectional designs of the previously mentioned studies and the absence of strength measures in the current study limit our ability to tease out whether or not the shorter COP-eCOM differences are primary deviations related to a lack of neuromuscular control or secondary compensation of the disease.…”

Section: Discussionsupporting

confidence: 80%

Altered Dynamic Postural Control during Step Turning in Persons with Early-Stage Parkinson’s Disease

Song

Sigward

Fisher

et al. 2012

Parkinson's Disease

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Persons withearly-stageParkinson’s disease (EPD) do not typically experience marked functional deficits but may have difficulty with turning tasks. Studies evaluating turning have focused on individuals in advanced stages of the disease. The purpose of this study was to compare postural control strategies adopted during turning in persons with EPD to those used by healthy control (HC) subjects. Fifteen persons with EPD, diagnosed within 3 years, and 10 HC participated. Participants walked 4 meters and then turned 90°. Dynamic postural control was quantified as the distance between the center of pressure (COP) and the extrapolated center of mass (eCOM). Individuals with EPD demonstrated significantly shorter COP-eCOM distances compared to HC. These findings suggest that dynamic postural control during turning is altered even in the early stages of PD.

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Section: Discussionsupporting

confidence: 80%

Altered Dynamic Postural Control during Step Turning in Persons with Early-Stage Parkinson’s Disease

Song

Sigward

Fisher

et al. 2012

Parkinson's Disease

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“…7 In recent clinical trials, decreased muscle strength has been observed in patients with PD. [8][9][10][11][12] Kakinuma et al measured the isokinetic muscle strength of knee extension and flexion and observed isokinetic strength reduction on the side more affected by PD. 12 Nallegowda et al tested the strength of the trunk, hip, and ankle flexor and extensor muscles using isokinetic measurements, and reported a decrease in strength in all the flexor and extensor muscle groups.…”

Section: Introductionmentioning

confidence: 99%

“…11 Finally, Nogaki et al hypothesised that muscle weakness in PD is likely to depend on movement velocity. 8,13 In contrast to the isokinetic evaluations described, some studies have evaluated quantitative isotonic and isometric muscle strength. 7,14,15 To date, no reported study has evaluated the isokinetic strength of the hip, knee, and ankle joints together.…”

Section: Introductionmentioning

confidence: 99%

Lower extremity isokinetic muscle strength in patients with Parkinson’s disease

Durmuş

Baysal

Altınayar

et al. 2010

Journal of Clinical Neuroscience

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“…Lower extremity muscle rigidity 13 , particularly in the hip flexors, may limit the ability to extend the hips during the backward stepping movement. Finally, muscle strength 25,26 , if impaired in the stepping or stance limb, may negatively impacted postural control during MSLT performance. Investigators should measure these biomechanical factors in the future to determine how they impact performance of each MSLT direction in PD.…”

Section: Discussionmentioning

confidence: 99%

Maximum Step Length Test Performance in People With Parkinson Disease: A Cross-sectional Study

Duncan

McNeely

Earhart

2017

Journal of Neurologic Physical Therapy

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Background and Purpose The Maximum Step Length Test (MSLT), a measure of one’s capacity to produce a large step, has been studied in older adults, but not in people with Parkinson disease (PD). We characterized performance and construct validity of the MSLT in PD. Methods Forty participants (mean age: 65.12±8.20; 45% female) with idiopathic PD completed the MSLT while OFF and ON anti-PD medication. Construct validity was investigated by examining relationships between MSLT and measures of motor performance. The following measures were collected: Mini-BESTest, ABC scale, gait velocity, 6MWT, MDS-UPDRS III, and TUG. A repeated measures ANOVA tested for main effects of medication and stepping direction and the interaction between the two. Pearson or Spearman correlations were used to assess the relationships between MSLT and motor performance measures (α=0.05). Results Regardless of medication status, participants stepped further in the forward direction compared to the backward and lateral directions (p<0.001). Participants increased MSLT performance when ON-medication compared to OFF-medication (p=0.004). Regardless of medication status, MSLT was moderately to strongly related to Mini-BESTest, TUG, and 6MWT. Discussion and Conclusions People with PD stepped furthest in the forward direction when performing the MSLT. Increased MSLT performance was observed ON-medication compared to OFF-medication; however, the small increase may not be clinically meaningful. Given the relationships between the MSLT and the Mini-BESTest, 6MWT, and TUG, MSLT performance appears to associated with balance and gait hypokinesia in people with PD. Video Abstract available for more insights from the authors (see Video, Supplemental Digital Content 1).

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Muscle weakness in Parkinson's disease: a follow-up study

Cited by 31 publications

References 7 publications

Altered Dynamic Postural Control during Step Turning in Persons with Early-Stage Parkinson’s Disease

Altered Dynamic Postural Control during Step Turning in Persons with Early-Stage Parkinson’s Disease

Lower extremity isokinetic muscle strength in patients with Parkinson’s disease

Maximum Step Length Test Performance in People With Parkinson Disease: A Cross-sectional Study

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