Muscle Strength is Impaired in Men but not in Women Living with HIV Taking Antiretroviral Therapy

Oliveira, Vitor H F; Wiechmann, Susana Lílian; Narciso, Argéria Maria Serraglio; Webel, Allison R.; Deminice, Rafael

doi:10.3851/imp3159

Cited by 12 publications

(11 citation statements)

References 47 publications

(71 reference statements)

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“…17 This information is relevant, since this problem is a predictor of functionality. The loss of muscle mass would be the probable contributing factor for this finding, 18 agreeing with the publication by Lédo et al 16 Oliveira et al 19 demonstrated in one study that HIV infection is associated with decreased muscle strength in men when compared to groups of non-HIV infected controls. However, this lower muscle strength observed in men was not associated with a decrease in muscle mass.…”

Section: Discussionsupporting

confidence: 80%

“…21,22 The physical consequences of HIV involve metabolic, neurological and structural, and inflammatory muscular abnormalities. 19 In addition, the use of ART has been associated with mitochondrial dysfunction and motor impairment. 23 In the present study, of the 71 individuals (41.27%) who used ART, 15.5% presented dynapenia, corroborating with findings in the literature, what associates clinical symptoms such as myalgia and muscle weakness after the use ART.…”

Section: Discussionmentioning

confidence: 99%

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Dinapenia e qualidade de vida em indivíduos infectados pelo HIV

et al. 2017

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The appearance of effective antiretroviral therapy (ART) has transformed the evolutionary profile of acquired human immunodeficiency virus (HIV) into a chronic disease, with increased life expectancy but complications related to its use, such as muscle weakness. Objective: Describe the occurrence of dynapenia and its relationship with quality of life in HIV infected individuals. Methods: This is a cross-sectional observational study, in which handgrip strength was evaluated with handgrip dynamometry. HIV-infected individuals aged ≥18 years and ability to have muscle strength measured were included. The diagnosis of dynapenia was determined by the literature for handgrip strength evaluation and body mass index (BMI). Short-Form Health Survey (SF-36) was used to evaluate the quality of life, and other variables such as time to use ART and the Charlson Comorbidity Index (CCI), as well as age, gender and weight were recorded. Results: The presence of dynapenia was 11.6% in the sample studied. There was an association of dynapenia with the variables age (p = 0.0001), presence of cormobities (p = 0.0001), lower handgrip strength (p = 0.0001) and lower BMI (p = 0.033). The quality of life has been compromised in both the physical and mental domains. Conclusion: There is dynapenia in part of the individuals with HIV and its association with poorer quality of life was found, what suggests the necessity of screening and treatment of this often underreported health problem in this population.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Dinapenia e qualidade de vida em indivíduos infectados pelo HIV

et al. 2017

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“…Consistent with these studies, levels of insulin and inflammation were stronger predictors of CRF in our sample rather than other variables, such as BMI. Others have also suggested that PLWH are predisposed to lower levels of physical fitness through cardiovascular mechanisms (i.e., presence of hypertension), rather than others (i.e., amount of lean body mass; Oliveira, Wiechmann, Narciso, Webel, & Deminice, 2018; Oursler et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level

Oliveira¹,

Perazzo²,

Deminice³

et al. 2018

Journal of the Association of Nurses in AIDS Care

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“…In addition to our findings, Yarasheski et al [55] reported lower muscle mass in men but higher muscle mass among women living with HIV compared with controls, after multivariable adjustment. Also, Oliveira et al [26] found impaired dynamic and isokinetic strength in men living with HIV, but not in women, compared with uninfected controls. One mechanism of this effect may be from greater body fat in women: studies on AIDS wasting disease observed that greater adipose tissue may protect against subsequent loss of muscle mass [56,57].…”

Section: Traditional and Hiv-related Risk Factors Contribute To The Dmentioning

confidence: 97%

“…In this review, we selected original sarcopenia studies which adopted one of the above-mentioned sarcopenia operational definitions. We are aware that there are a large body of literature that has assessed and described the characteristics of muscle mass or function in PLHIV, variables which were usually impaired compared with people without HIV [7,26,27]. But because these variables have been assessed separately, or studies did not employ a cut point to classify subjects with low or normal range, these studies were not included in this review.…”

Section: Sarcopenia Definitionmentioning

confidence: 99%

Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis

et al. 2020

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People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among PLHIV, and to compare the prevalence of sarcopenia among PLHIV and people without HIV. A systematic literature search of the PubMed, Embase, Cinahl, and Scielo databases was performed following PRISMA and MOOSE guidelines. Identified articles were included if they evaluated sarcopenia among PLHIV using either the presence of low muscle mass only or low muscle mass in association with low muscle function. The pooled prevalence of sarcopenia among PLHIV and the odds ratio for sarcopenia in PLHIV compared with controls were calculated. From 13 studies and 2267 participants, the prevalence of sarcopenia among PLHIV was 24.1% (95% CI = 17.8-31.0%). PLHIV presented 6.1 greater odds (95% CI = 1.1-33.5) of sarcopenia compared with people without HIV, matched by age, sex, BMI, and ethnicity. Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. CRD42019131449.

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Muscle Strength is Impaired in Men but not in Women Living with HIV Taking Antiretroviral Therapy

Abstract: HIV infection is associated with impaired dynamic and isokinetic strength in men compared to HIV-uninfected controls, but not in women.

Cited by 12 publications

References 47 publications

Dinapenia e qualidade de vida em indivíduos infectados pelo HIV

Dinapenia e qualidade de vida em indivíduos infectados pelo HIV

Association Between the 6-Minute Walk Test Distance and Peak Cardiorespiratory Fitness Among People Living with HIV Varies by Fitness Level

Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis

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