Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies

Patterson, Brooke E; Girdwood, Michael; West, Thomas J; Bruder, Andrea M; Øiestad, Britt Elin; Juhl, Carsten Bogh; Culvenor, Adam G

doi:10.1007/s00256-022-04266-4

Cited by 14 publications

(7 citation statements)

References 64 publications

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“…Knee flexor function is considered important for knee joint health in individuals with or at risk of KOA. 6 Wild et al 31 suggested that decreased hamstring muscle strength leads to misalignment of the frontal plane of the knee joint in KOA patients, compromising the control of knee joint alignment and increasing the load on the knee, thus elevating the risk of KOA. The knee flexors are increasingly recognized as having a significant impact on knee kinematics and kinetics.…”

Section: How Does Muscle Strength Affect Koa?mentioning

confidence: 99%

“…However, some researchers have found that low knee flexor strength is associated with an increased risk of worsening tibiofemoral osteoarthritis. Knee flexor function is considered important for knee joint health in individuals with or at risk of KOA 6 . Wild et al 31 .…”

Section: Muscle Strengthmentioning

confidence: 99%

“…4,5 Additionally, diminished strength in the knee extensors and flexors increases the risk of deterioration in tibiofemoral arthritis and patellofemoral arthritis. 6 Elderly individuals aged 70-80 with the lowest muscle density quartile faced a 51% higher risk of hospitalization compared to those in the highest quartile. 7 Conversely, the restoration of MF and MQ can alleviate pain, improve joint function, and enhance the quality of life for individuals with KOA.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, reduced quadriceps strength can exacerbate knee pain in patients with KOA and contribute to disease progression 4,5 . Additionally, diminished strength in the knee extensors and flexors increases the risk of deterioration in tibiofemoral arthritis and patellofemoral arthritis 6 . Elderly individuals aged 70–80 with the lowest muscle density quartile faced a 51% higher risk of hospitalization compared to those in the highest quartile 7 .…”

Section: Introductionmentioning

confidence: 99%

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How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

Chen,

Zhou,

Gong

et al. 2024

Orthopaedic Surgery

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Knee osteoarthritis (KOA) is widely recognized as a chronic joint disease characterized by degeneration of knee cartilage and subsequent bone hyperplasia. However, it is important to acknowledge the significant role of muscles in the development and progression of KOA. Muscle function (MF) and muscle quality (MQ) are key factors in understanding the involvement of muscles in KOA. Quantitative indices such as muscle mass, muscle strength, muscle cross‐sectional area, muscle thickness, and muscle fatigue are crucial in assessing MF and MQ. Despite the growing interest in KOA, there is a scarcity of studies investigating the relationship between muscles and this condition. This review aims to examine the commonly used indices and measurement methods for assessing MF and MQ in clinical settings, while also exploring the association between muscles and KOA. Furthermore, this article highlights the importance of restoring MF and MQ to enhance symptom management and improve the quality of life for patients with KOA.

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Section: How Does Muscle Strength Affect Koa?mentioning

confidence: 99%

Section: Muscle Strengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

Chen,

Zhou,

Gong

et al. 2024

Orthopaedic Surgery

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“…Exercise interventions involve many different activities, such as strength and balance exercises, walking programs, cycling, or waterbased exercises which make a good base for personalized treatment options. Strength exercises are likely to be among the most important interventions due to the relatively strong association between lower knee extensor strength and increased risk of symptomatic and functional deterioration in individuals with symptomatic knee osteoarthritis [12]. However, fewer studies have reported the effects of strength training on knee-related QoL in younger populations in the longer term [9].…”

Section: Introductionmentioning

confidence: 99%

The long-term efficacy of strength or aerobic exercise on quality of life and knee function in patients with knee osteoarthritis. A multi-arm randomized controlled trial

Øiestad

Årøen

Røtterud

et al. 2023

Preprint

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Objective To evaluate the efficacy of strength exercise or aerobic exercise compared to usual care on knee-related quality of life (QoL) and knee function after 4 months and 1 year in individuals with knee osteoarthritis. Methods A three-arm randomized controlled trial (RCT) compared 12-weeks of strength exercise or aerobic exercise (stationary cycling) to usual care supervised by physiotherapists in primary care. We recruited 168 participants aged 35–70 years with symptomatic knee osteoarthritis. Primary outcome was The Knee Injury and Osteoarthritis Outcome Score (KOOS) QoL after 1 year. Secondary outcomes were self-reported function, pain, and self-efficacy, muscle strength and voluntary maximal oxygen consumption (VO2peak) at 4 months and 1 year. Results There were no differences between strength exercise and usual care on KOOS QoL (6.5, 95% CI -0.9 to 14), or for aerobic exercise and usual care (5.0, 95% CI -2.7 to 12.8), at 1 year. The two exercise groups showed better quadriceps muscle strength, and VO2peak at 4-months, compared to usual care. Conclusion This trial found no statistically significant effects of two exercise programs compared to usual care on KOOS QoL after 1 year in individuals with symptomatic and radiographic knee osteoarthritis, but an underpowered sample size may explain lack of efficacy between the intervention groups and the usual care group.

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Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis

Wu,

Boer,

Hofman

et al. 2024

JAMA Netw Open

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ImportanceIt has been demonstrated that total physical activity is not associated with risk of osteoarthritis. However, the association of different types of physical activity with incident knee osteoarthritis remains unclear.ObjectiveTo determine whether weight-bearing recreational physical activities are associated with increased risk of incident knee osteoarthritis.Design, Setting, and ParticipantsThis prospective cohort study used data from the Rotterdam Study (1996 to 2009), including participants with knee x-ray measurements at baseline and follow-up examinations. Participants with knee osteoarthritis at baseline were excluded. Residents aged 45 years and older of the Ommoord district in the city of Rotterdam in The Netherlands were invited to join the Rotterdam Study (78% response rate). Analysis was conducted in June 2023.ExposureTotal, weight-bearing, and non–weight-bearing recreational physical activities collected by questionnaires at baseline.Main Outcomes and MeasuresIncident radiographic knee osteoarthritis measured by knee x-ray was the primary outcome, and incident symptomatic knee osteoarthritis defined by x-ray and knee pain questionnaire was the secondary outcome. The association of different types of recreational physical activity with radiographic knee osteoarthritis was examined using logistic regression within generalized estimating equation framework after adjusting for potential confounders. A prespecified stratification analysis was planned on the basis of lower-limb muscle mass index (LMI) tertiles, measured by dual-energy x-ray absorptiometry.ResultsA total of 5003 individuals (2804 women [56.0%]; mean [SD] age, 64.5 [7.9] years) were included. The knee osteoarthritis incident rate was 8.4% (793 of 9483 knees) for a mean (SD) follow-up time of 6.33 (2.46) years. Higher weight-bearing activity was associated with increased odds of incident knee osteoarthritis (odds ratio [OR], 1.22; 95% CI, 1.10-1.35; P &lt; .001), but non–weight-bearing activity was not (OR, 1.04; 95% CI, 0.95-1.15; P = .37). In the analysis stratified by LMI tertiles, the association of weight-bearing activity with incident osteoarthritis was found only among 431 patients in the lowest LMI tertile (OR, 1.53; 95% CI, 1.15-2.04; P = .003), but not among patients in the middle or high LMI tertile.Conclusions and RelevanceThe findings of this study suggest that weight-bearing activity is associated with incident knee osteoarthritis in people with low levels of lower-limb muscle mass, which might be a promising avenue for tailored advice for physical activity.

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Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies

Cited by 14 publications

References 64 publications

How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

How Do Muscle Function and Quality Affect the Progression of KOA? A Narrative Review

The long-term efficacy of strength or aerobic exercise on quality of life and knee function in patients with knee osteoarthritis. A multi-arm randomized controlled trial

Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis

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