Muscle quality indices separately associate with joint-level power-related measures of the knee extensors in older males

Hirata, Kosuke; Ito, Mari; Nomura, Yuta; Kawashima, Chiho; Tsuchiya, Yuma; Ooba, Kosuke; Yoshida, Tsukasa; Yamada, Yosuke; Power, Geoffrey A.; Tillin, Neale A.; Akagi, Ryota

doi:10.1007/s00421-022-05005-2

Cited by 4 publications

(13 citation statements)

References 44 publications

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“…The 51 included studies included 5095 (∼2759 females, ∼2301 males) participants, aged 72.5±5.8 years of age. 7,11,12,14–24,26–62 Twenty-seven studies included males and females, 14,17,20,23,24,26,28–30,32,33,36–38,40,42,45–47,49,54,57–62 while 16 included only males, 7,11,15,16,18,19,21,22,31,34,39,41,48,50,52,56 seven included only females, 27,35,43,44,51,53,55 a single study did not report sex, 12 while another did not delineate sex when reporting age or participant numbers; 61 explaining the approximate values in the previous sentence. Two studies included participants with ‘metabolic syndrome’ or diabetes, 20,33 and single studies included participants with chronic obstructive pulmonary disease, 42 USA Veterans, 11 ‘frail’, 24 outpatients, 63 nursing home residents, 23 or regularly participated in competitive tennis.…”

Section: Resultsmentioning

confidence: 99%

“…The rectus femoris was the most common (n=33) isolated muscle included in correlations, 7,11,12,14,17,18,20,22–24,28,29,31–37,39–41,43,46,47,53–57,59–62 followed by the vastus lateralis (n=11), 12,28,29,36,38,39,51,53,56,59,62 medial gastrocnemius (n=7), 15,16,32,33,36,40,48 vastus intermedius (n=7), 12,20,41,47,53,56,57 lateral gastrocnemius (n=4), 15,22,40,48 biceps brachii (n=4), 22,23,32,33 vastus medialis (n=3), 12,53,56 tibialis anterior (n=3), 22,36,42 and triceps brachii (n=3). 22,32,33 Single studies reported correlations with the multifidus, 44 erector spinae, 44 gluteus medius, 38 masseter, 58 psoas major, 44 or rectus abdominis 22 muscles.…”

Section: Resultsmentioning

confidence: 99%

“…The most common functional test was peak force or torque during isometric knee extension (n=22) 7,12,14,17,18,20,22,23,27,31,35,39,43,47,48,53–57,59,60 or flexion (n=2), 22,52 followed by measures of grip strength (n=20), 11,14,20,22–24,28,32,33,37,40,45,46,48,53,57,58,60–62 walking speed (n=16), 14,17,20,32,33,36,40,44,45,47,53,54,57,58,60,61 sit-to-stand (n=16), 22,23,28,29,38,40,41,43,49,53,56,57,59–62 timed up-and-go (n=10), 17,20,38,45,47,49,51,57,60,61 concentric knee extension force or power, (n=8) 11,22,30,31,39,45,48,56 isometric or concentric plantar-flexion (n=5) strength, power or velocity, 15,16,19,26,48 single leg balance or posture (n=5), …”

Section: Resultsmentioning

confidence: 99%

“…This study's primary and largest meta-analysis examined the relationships between quadriceps muscle echogenicity and knee extension strength. This pooled analysis included 20 studies and 2924 older adults 7,12,17,18,20,22,23,23,27,30,31,35,37,39,43,45,47,[54][55][56] and demonstrated a modest, negative relationship, with relatively narrow confidence intervals (r=-0.36 [95%CI: -0.38, -0.32], p<0.001). Quadriceps strength has demonstrated moderate to strong relationships to functional tasks, 23 with lower quadriceps strength increasing the odds (OR=3 [95%CI, 1.78 to 5.05]) of falls within older adults.…”

Section: Discussionmentioning

confidence: 99%

“…45 Ten studies included at least one measure of rapid force/torque/velocity production. 16,19,21,34,39,[52][53][54]56,62…”

Section: Quadricepsmentioning

confidence: 99%

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Exploring the associations between skeletal muscle echogenicity and physical function in aging adults: A systematic review with meta-analyses

Oranchuk,

Bodkin,

Boncella

et al. 2023

Preprint

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BackgroundAssessment and quantification of skeletal muscle within the aging population is vital for diagnosis, treatment, and injury/disease prevention. The clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting diseases. However, relationships between muscle echogenicity and clinical functional assessments require authoritative analysis. Thus, we aimed to 1) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older (≥60 years) adults, 2) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function, and 3) perform sub-analyses to determine between-muscle relationships.MethodsCINAHL, Embase, MEDLINE, PubMed, and Web of Science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older adults. Meta-analyses with and without sub-analysis for individual muscles were performed utilizing Fisher’s Z transformation for the most common measures of physical function. Fisher’s Z was back-transformed to Pearson’srfor interpretation.ResultsFifty-one articles (N=5095, female=∼2759, male=∼2301, 72.5±5.8 years [one study did not provide sex descriptors]) were extracted for review, with previously unpublished data obtained from the authors of 12 studies. The rectus femoris (n=32) and isometric knee extension strength (n=22) were the most accessed muscle and physical qualities, respectively. The relationship between quadriceps echogenicity and knee extensor strength was moderate (n=2924,r=-0.36 [95%CI: −0.38 to −0.32],p<0.001), with all other meta-analyses (grip strength, walking speed, sit- to-stand, timed up-and-go) resulting in slightly weaker correlations (r=−0.34 to −0.23, allp<0.001). Sub-analyses determined minimal differences in predictive ability between muscle groups, although combining muscles (e.g., rectus femoris+vastus lateralis) often resulted in stronger correlations with maximal strength.ConclusionsWhile correlations were modest, the affordable, portable, and noninvasive ultrasonic assessment of muscle quality was a consistent predictor of physical function in older adults. Minimal between-muscle differences suggest that echogenicity estimates of muscle quality are systemic. Therefore, practitioners may be able to scan a single muscle to assess full-body skeletal muscle quality/composition, while researchers should consider combining multiple muscles to strengthen the model.RegistrationThe original protocol was prospectively registered at the National Institute of Health Research PROSPERO (CRD42020201841).HighlightsRelationships between skeletal muscle echogenicity and physical function were small to moderate, but highly consistent.Sub-analyses determined minimal between-muscle differences in predictive ability.Ultrasonic echogenicity should be considered part of early detection screens for sarcopenia and other diseases.Combining muscles tended to strengthen the model, although muscle quality appears systemic, allowing for a single scan to represent the total body.

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