Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise

Kim, Ki‐Young; Ku, Sae‐Kwang; Lee, Ki-Won; Song, Chang‐Hyun; An, Won Gun

doi:10.1016/j.jep.2017.10.022

Cited by 35 publications

(47 citation statements)

References 35 publications

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“…Therefore, the effect of SC extract on humans is not yet clear. Recently, two studies have shown that SC supplementation increased calf muscle strength as well as muscle mass in mice [13,28]. Our study, however, is the first to investigate the association between muscle strength and SC extract in humans.…”

Section: Discussionmentioning

confidence: 80%

“…Trapani et al reported that the contractive strength of muscles is determined by the activity of adenosine triphosphatase (ATPase) [39]. In addition, SC extract supplementation has been shown to increase ATPase activity in gastrocnemius and soleus muscles in mice [13]. This may be the theoretical basis for the mechanism of increase in muscle strength by SC extract supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…The SC provided by the company has been proven effective through animal studies [3,4,13,28], and the safety of the human body has been confirmed by the Regional Clinical Trials Center, Dong-A University, Busan, Korea.…”

Section: Administration Of the Sc Supplementsmentioning

confidence: 94%

“…Previous animal studies showed that the optimal dose for the effects of SC extract on muscle strength was 250 mg/kg [13,28].…”

Section: Administration Of the Sc Supplementsmentioning

confidence: 99%

“…Recent animal studies have reported beneficial effects of SC extract, for example, its supplementation appears to decrease protein degradation and increase protein synthesis, as well as display antioxidant and anti-inflammatory effects on skeletal muscle fibers [13,14]. Additionally, SC extract was also found to improve mass and strength in skeletal muscle, as well as endurance in mice [13][14][15]. However, in humans, SC extract may not be as effective as in animals.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Schisandra chinensis Extract Supplementation on Quadriceps Muscle Strength and Fatigue in Adult Women: A Randomized, Double-Blind, Placebo-Controlled Trial

jinkee¹,

Han

Park

2020

IJERPH

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The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). In animal studies, SC extract supplementation had beneficial effects on muscle strength and lactate level. However, the effect of SC extract supplementation on skeletal muscle strength and lactate at rest in humans remains unclear. The purpose of this study was to evaluate the effect of SC extract supplementation on quadriceps muscle strength (QMS) and lactate at rest in adult women. Forty five healthy post-menopausal middle-aged women (61.9 ± 8.4 years) were randomly divided into the SC (n = 24) or the placebo group (n = 21). The SC group consumed 1000 mg of SC extract per day, whereas the placebo group consumed 1000 mg of starch per day for 12 weeks. The difference in muscle mass, physical function, and biomarkers and the relative changes between baseline and 12 weeks were evaluated. We used two-factor repeated measures analysis of variance (ANOVA) to determine interaction (group × time) effects for variables. Statistical significance was accepted at p < 0.05. In ANOVA results, QMS (p = 0.001) and lactate level (p = 0.038) showed significant interactions. With paired t-tests, QMS was significantly increased (p < 0.001) and lactate level at rest was significantly decreased (p < 0.05) after 12 weeks in the SC group. However, no interactions were found between the other variables. Supplementation of SC extract may help to improve QMS as well as decrease lactate level at rest in adult women. We believe that SC extract is a health supplement that can support healthy life in this population.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%