Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study

Cousins, Julie M.; Petit, Moira A.; Paudel, Misti L.; Taylor, Brent C.; Hughes, Julie M.; Cauley, Jane A.; Zmuda, Joseph M.; Cawthon, Peggy M.; Ensrud, Kristine E.

doi:10.1016/j.bone.2010.05.003

Cited by 62 publications

(66 citation statements)

References 30 publications

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“…Our findings are consistent with the Osteoporotic Fractures in Men Study, which has shown that men in the lowest quartile of grip strength had smaller bones, lower cortical area, and stress strain index at the diaphysis of the radius 36. Similarly, in the Hertfordshire Cohort Study, positive associations in men aged 70 years and over between grip strength and diaphyseal periosteal circumference, stress strain index, and cortical bone area were reported 37.…”

Section: Discussionsupporting

confidence: 90%

Associations of muscle force, power, cross‐sectional muscle area and bone geometry in older UK men

Zengin

Pye

Cook

et al. 2017

J cachexia sarcopenia muscle

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BackgroundAgeing is associated with sarcopenia, osteoporosis, and increased fall risk, all of which contribute to increased fracture risk. Mechanically, bone strength adapts in response to forces created by muscle contractions. Adaptations can be through changes in bone size, geometry, and bending strength. Muscle mass is often used as a surrogate for muscle force; however, force can be increased without changes in muscle mass. Increased fall risk with ageing has been associated with a decline in muscle power—which is a measure of mobility. The aims of this study were as follows: (i) to investigate the relationship between muscle parameters in the upper and lower limbs with age in UK men and the influence of ethnicity on these relationships; (ii) to examine the relationships between jump force/grip strength/cross‐sectional muscle area (CSMA) with bone outcomes at the radius and tibia.MethodsWhite European, Black Afro‐Caribbean, and South Asian men aged 40–79 years were recruited from Manchester, UK. Cortical bone mineral content, cross‐sectional area, cortical area, cross‐sectional moment of inertia, and CSMA were measured at the diaphysis of the radius and tibia using peripheral quantitative computed tomography. Lower limb jump force and power were measured from a single two‐legged jump performed on a ground‐reaction force platform. Grip strength was measured using a dynamometer. Associations between muscle and bone outcomes was determined using linear regression with adjustments for age, height, weight, and ethnicity.ResultsThree hundred and one men were recruited. Jump force was negatively associated with age; for every 10 year increase in age, there was a 4% reduction in jump force (P < 0.0001). There was a significant age–ethnicity interaction for jump power (P = 0.039); after adjustments, this was attenuated (P = 0.088). For every 10 year increase in age, grip strength decreased by 11%. Jump force was positively associated with tibial bone outcomes: a 1 standard deviation greater jump force was associated with significantly higher cortical bone mineral content 3.1%, cross‐sectional area 4.2%, cortical area 3.4%, and cross‐sectional moment of inertia 6.8% (all P < 0.001). Cross‐sectional muscle area of the lower leg was not associated with tibial bone outcomes. Both grip strength and CSMA of the arm were positively associated, to a similar extent, with radius diaphyseal bone outcomes.ConclusionsJump force and power are negatively associated with age in UK men. In the lower limb, the measurement of jump force is more strongly related to bone outcomes than CSMA. It is important to consider jump force and power when understanding the aetiology of bone loss and mobility in ageing men.

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Section: Discussionsupporting

confidence: 90%

Associations of muscle force, power, cross‐sectional muscle area and bone geometry in older UK men

Zengin

Pye

Cook

et al. 2017

J cachexia sarcopenia muscle

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“…In addition, grip strength has been demonstrated as a strong predictor of bone strength at the distal radius shaft [24]. Although the 30-s chair stand test has not been used to assess the relationship between lower extremity strength to bone strength, a positive association between peak leg extensor power and estimated bone strength at the shaft and distal sites in the lower leg has been demonstrated in older individuals [29,40]. While this research used seated knee extension equipment versus the sit-to-stand motion, the techniques have been correlated significantly to chair rises in elderly subjects [41], and knee extensor strength and power are associated with improved performance on the 30-s chair stand test [30].…”

Section: Discussionmentioning

confidence: 99%

“…The 30-s chair stand test has been referred to as a functionally relevant measure of lower extremity strength in older adults [26], with the individual performing as many repetitions of a full stand and return to the sitting position in 30 s, without the assistance of the upper extremities [27]. Rapid sit-to-stand performance provided a combined measure of strength and power; both of which have been associated with estimated bone strength in the lower limb [28][29][30]. The 30-s chair stand test is also associated with fall risk and functional ability in older adults [26] and thus clinically is used to assist prediction of future fracture risk.…”

Section: Background Characteristicsmentioning

confidence: 99%

Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

et al. 2015

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“…(11) Grip strength was positively associated with both aBMD (12)(13)(14)(15)(16) and volumetric BMD (17)(18)(19) at the distal ORIGINAL ARTICLE…”

Section: Introductionmentioning

confidence: 99%

Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

Szulc

Blaizot

Boutroy

et al. 2012

Journal of Bone and Mineral Research

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The aim was to study the association between bone microarchitecture and muscle mass and strength in older men. Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men aged !60 years at the distal radius by high-resolution peripheral computed tomography (HR-pQCT). Areal bone mineral density (aBMD) and appendicular muscle mass (ASM) were assessed by dual-energy X-ray absorptiometry (DXA). Relative ASM of the upper limbs (RASM-u.l.) was calculated as ASM of the upper limbs/ (height) 2 . Grip strength was measured by dynanometry. In multivariable models, men in the lowest RASM-u.l. quartile had lower crosssectional area (CSA), cortical area (Ct.Ar), cortical thickness (Ct.Th), and trabecular area (Tb.Ar) at distal radius compared with men in the highest quartile. The trends remained significant after adjustment for grip strength. Men in the lowest quartile of the normalized grip strength (grip strength/ [height] 2 ) had lower aBMD, total vBMD, Ct.Ar, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp and Tb.Sp.SD. The associations for Ct.Ar, total vBMD, Ct.Th, Tb.vBMD, and Tb.Sp remained significant after adjustment for RASM-u.l. In the models including RASM-u.l. and normalized grip strength, CSA and Tb.Ar were associated with RASM-u.l. but not with the strength. Lower Ct.Th, Tb.vBMD, and Tb.N were associated with lower grip strength but not with RASM-u.l. Lower Ct.Ar was associated with lower grip strength and with lower RASM-u.l. In conclusion, in older men, low RASM-u.l. and low grip strength are associated with poor cortical and trabecular microarchitecture partly independently of each other, after adjustment for confounders. ß

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Muscle power and physical activity are associated with bone strength in older men: The osteoporotic fractures in men study

Cited by 62 publications

References 30 publications

Associations of muscle force, power, cross‐sectional muscle area and bone geometry in older UK men

Associations of muscle force, power, cross‐sectional muscle area and bone geometry in older UK men

Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture

Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

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