Muscle PGC-1α modulates hepatic mitophagy regulation during aging

Christensen, Natascha Masselkhi; Ringholm, Stine; Buch, Bjørg Thiellesen; Gudiksen, Anders; Halling, Jens Frey; Pilegaard, Henriette

doi:10.1016/j.exger.2022.112046

Cited by 3 publications

(1 citation statement)

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“…However, more opinions tend to support the idea that the elevation of p62 serves as an ubiquitin receptor to mediate the degradation of exercise-induced damaged substrates through selective autophagy. Many works have shown that elevated p62 is translocated to the damaged mitochondria and induces mitophagy, which might connect to the survival and maintenance of persistently normal mitochondrial [ 27 – 29 ]. In our study, we observed that both autophagosomes and autolysosomes were increased, indicating that no disorder of autophagy degradation occurs during exhaustive exercise.…”

Section: Discussionmentioning

confidence: 99%

High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle

Lu,

Zhang,

Liu

et al. 2023

J Physiol Sci

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This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased. HIIT intervention before exhaustive exercise could decrease myofibril injury and BiP levels, accompanied by down-regulation of HSP70/BAG3 complex and selective autophagy. In conclusion, exhaustive exercise promotes CASA to clear protein aggregation for keeping proteostasis in muscle fibers; pre-HIIT intervention improves myofibril injury and unfold protein response caused by exhaustive exercise, which might contribute to inhibit the augmentation of CASA.

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Section: Discussionmentioning

confidence: 99%