Muscle Pain

Mense, Siegfried

doi:10.3238/artzebl.2008.0214

Cited by 65 publications

(45 citation statements)

References 29 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…44 This difference could be attributed to the variation in their innervation by large and small fibers. For instance, about 47% of afferents innervating muscles have myelinated axons compared to 24% of those innervating the skin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Resiniferatoxin (RTX) Causes a Uniquely Protracted Musculoskeletal Hyperalgesia in Mice by Activation of TRPV1 Receptors

Abdelhamid

Kovács

Honda

et al. 2013

The Journal of Pain

View full text Add to dashboard Cite

Inactivation of TRPV1 receptors is one approach to analgesic drug development. However, TRPV1 receptors exert different effects on each modality of pain. Because muscle pain is clinically important, we compared the effect of TRPV1 ligands on musculoskeletal nociception to that on thermal and tactile nociception. Injected parenterally, capsaicin had no effect on von Frey fiber responses (tactile) but induced a transient hypothermia and hyperalgesia in both the tail flick (thermal) and grip force (musculoskeletal) assays, presumably by its agonistic action at TRPV1 sites. In contrast, RTX produced a chronic (>58 days) thermal antinociception, consistent with its reported ability to desensitize TRPV1 sites. In the same mice, RTX produced a transient hypothermia (7 h) and a protracted (28 day) musculoskeletal hyperalgesia in spite of a 35.5% reduction in TRPV1 receptor-immunoreactivity in muscle afferents. Once musculoskeletal hyperalgesia subsided, mice were tolerant to the hyperalgesic effects of either capsaicin or RTX while tolerance to hypothermia did not develop until after three injections. Musculoskeletal hyperalgesia was prevented but not reversed by SB-366791, a TRPV1 antagonist, indicating that TRPV1 receptors initiate but do not maintain hyperalgesia. Injected intrathecally, RTX produced only a brief musculoskeletal hyperalgesia (2 days) after which mice were tolerant to this effect. Perspective The effect of TRPV1 receptors varies depending on modality and tissue type such that RTX causes thermal antinociception, musculoskeletal hyperalgesia, and no effect on tactile nociception in healthy mice. Spinal TRPV1 receptors are a potential target for pain relief as they induce only a short musculoskeletal hyperalgesia followed by desensitization.

show abstract

Section: Discussionmentioning

confidence: 99%

“…5,70,72 Approximately 39% of men and 45% of women report chronic musculoskeletal pain, 71 describing it as dull and aching rather than epicritic. 44 A variety of modulators of primary afferent C-fiber activity (e.g. lactate and ATP), are poised to serve as endogenous mediators of musculoskeletal pain.…”

Section: Introductionmentioning

confidence: 99%

Resiniferatoxin (RTX) Causes a Uniquely Protracted Musculoskeletal Hyperalgesia in Mice by Activation of TRPV1 Receptors

Abdelhamid

Kovács

Honda

et al. 2013

The Journal of Pain

View full text Add to dashboard Cite

show abstract

“…4 This sustained contraction of muscle can lead to a significant increase in the concentration of inflammatory and nociceptive transmitters within the trigger point, as measured by real-time microdialysis in a landmark study by Shah et al 5 Persistent peripheral muscle nociceptive activation by these inflammatory and nociceptive compounds is converted into a permanent stimulus that facilitates pain neurotransmission and leads to central sensitization and glial activation. 6–8 …”

Section: Introductionmentioning

confidence: 99%

Botulinum Toxin Type A Injections for Cervical and Shoulder Girdle Myofascial Pain Using an Enriched Protocol Design

Nicol

Ferrante

2014

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

Background Myofascial pain syndrome is a regional condition of muscle pain and stiffness and is classically characterized by the presence of trigger points in affected musculature. Botulinum toxin type A (BoNT-A) has been shown to have antinociceptive properties and elicit sustained muscle relaxation, thereby possibly affording even greater relief than traditional strategies. Our goal in this study was to determine whether direct injection of BoNT-A into painful muscle groups is effective for cervical and shoulder girdle myofascial pain. Methods An enriched protocol design was used wherein 114 patients with cervical and shoulder girdle myofascial pain underwent injection of BoNT-A to determine their response to the drug. Fifty-four responders were then enrolled in a twelve-week, randomized, double-blind, placebo-controlled trial. Pain scales and quality of life measures were assessed at baseline and at routine follow-up visits until completion of the study after 26 weeks. Results Injection of BoNT-A into painful muscle groups improved average visual numerical pain scores in subjects who received a second dose of BoNT-A compared to placebo (p = 0.019 (0.26, 2.78)). Subjects who received a second dose of BoNT-A had a reduced number of headaches per week (p = 0.04 (0.07, 4.55)). Brief Pain Inventory interference scores for general activity and sleep were improved (p = 0.046 (0.038, 3.7) and 0.02 (0.37, 4.33), respectively) in those who received a second dose of BoNT-A. Conclusion Botulinum toxin type A injected directly into painful muscle groups improves average pain scores and certain aspects of quality of life in patients suffering from severe cervical and shoulder girdle myofascial pain.

show abstract

“…Keadaan iskemik ini membuat jaringan mikrosirkulasi karena vasokonstriksi pembuluh darah, mengalami kekurangan nutrisi dan oksigen serta menumpuknya zat-zat sisa metabolisme dan timbul viscous circle. Keadaan ini akan merangsang ujung-ujung saraf tepi nosiseptife C untuk melepaskan suatu neuropeptida yaitu substansi P. Adanya pelepasan substansi P akan membebaskan prostaglandin dan diikuti juga dengan pembebasan bradikinin, histamin, serotonin sehingga dapat menimbulkan nyeri (Mense, 2001).…”

Section: Aktivitasunclassified

Penurunan Nyeri Myofascial Trigger Point Syndrom (Mtps) Otot Bisep Dan Trisep Dengan Metode Gelatik

Lestari¹

2018

jmk

View full text Add to dashboard Cite

The incidence of MTPS is still high, especially on the field workers in theMunicipal Water Company (PDAM) of Bengkulu City with signs and symptoms of painin the biceps and triceps. Isometric exercise is one of the practical and economical waysto reduce pain. The aim of the research was to know the effect of isometric exercisemovement on the decrease of biceps and tricep's biceps BMPS on the field worker inPDAM Kota Bengkulu. This research was an analytic research, which uses one grouppre-test post-test design. The sample in this research was PDAM Bengkulu field workeris 21 people. Data collection by measuring the scale of pain in the biceps and triceps.Data analysis was conducted in quantitative manner ie univariate and bivariate. Based onthe result of the research, it was found that the average value of pain scale beforeperforming gelatik is 3.52 with 95% CI 3,13-3,92. After 2 weeks of gelatik was done asmuch as 6 times got the pain scale of respondent was 3,00 with 95% CI 2,71-3,29Wilcoxon test result got p value <0,05 (0,012). This method is expected to be applied tothe program of PDAM Kota Bengkulu with the implementation of gelatik 3 times a weekto reduce the pain of MTPS.

show abstract

Muscle Pain

Cited by 65 publications

References 29 publications

Resiniferatoxin (RTX) Causes a Uniquely Protracted Musculoskeletal Hyperalgesia in Mice by Activation of TRPV1 Receptors

Resiniferatoxin (RTX) Causes a Uniquely Protracted Musculoskeletal Hyperalgesia in Mice by Activation of TRPV1 Receptors

Botulinum Toxin Type A Injections for Cervical and Shoulder Girdle Myofascial Pain Using an Enriched Protocol Design

Penurunan Nyeri Myofascial Trigger Point Syndrom (Mtps) Otot Bisep Dan Trisep Dengan Metode Gelatik

Contact Info

Product

Resources

About