Muscle Oxygenation during Exercise under Hypoxic Conditions Assessed by Spatial-Resolved Broadband NIR Spectroscopy

Geraskin, Dmitri; Platen, Petra; Franke, Julia; André, C.; Bloch, Wilhelm; Kohl‐Bareis, Matthias

doi:10.1364/ecbo.2005.we4

Cited by 5 publications

(6 citation statements)

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“…An earlier version of the system and the underlying method has been previously described in the literature (Geraskin et al 2005Soschinski et al 2007). Two approaches were followed for NIR data analysis.…”

Section: Optical Spectroscopy Set-upmentioning

confidence: 99%

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Warnecke

Wendt

Winkler

et al. 2014

Can. J. Physiol. Pharmacol.

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Topical agents like nonivamide and nicoboxil induce hyperaemisation and increase cutaneous blood flow and temperature. This study aimed to determine the effects of a nonivamide-nicoboxil cream on haemodynamics in the skin and calf muscle, via optical spectroscopy, discriminating between the changes for skin and muscle. Optical spectroscopy was applied in the visible (VIS) and near-infrared (NIR) wavelength range. The study determined the effect of the cream on changes in oxygenated (ΔoxyHb) and deoxygenated (ΔdeoxyHb) haemoglobin in skin and muscle, as well as on tissue oxygen saturation (SO2) in the skin of 14 healthy subjects. The left and right calves of the subjects were either treated with nonivamide-nicoboxil cream or were sham-administered. NIR spectroscopy allows noninvasive in-vivo examination of the oxygenation of human skeletal muscle. Topical administration of the nonivamide-nicoboxil cream significantly increased the concentration of oxygenated haemoglobin and tissue oxygen saturation in the skin, as well as the concentration of oxygenated haemoglobin in the muscle of the treated legs after 15 min, but with stronger and faster effects in the skin. The topical application of the nonivamide-nicoboxil cream increased blood flow in (smaller vessels of) the skin and muscle tissues.

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Section: Optical Spectroscopy Set-upmentioning

confidence: 99%

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Warnecke

Wendt

Winkler

et al. 2014

Can. J. Physiol. Pharmacol.

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“…An earlier version of the system and the underlying method is described in the literature [24,25,26]. Two approaches were followed for the NIR data analysis.…”

Section: Optical Spectroscopy Set-upmentioning

confidence: 99%

“…From the broad-band spectra of attenuation, changes in haemoglobin concentrations were calculated by matrix inversion. Second, the spatially-resolved spectroscopy (SRS) approach based on the derivative ∂A/∂ρ of attenuation A with respect to the source-detector distance ρ was used to calculate absolute absorption coefficients μ a [29,30,24]. Again, matrix inversion allows the absolute concentrations of haemoglobin to be calculated.…”

Section: Optical Spectroscopy Set-upmentioning

confidence: 99%

Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

et al. 2011

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Topical agents inducing hyperaemisation like nonivamide or nicoboxil increase cutaneous blood flow and temperature and induce erythema. It is not proven up to now whether there is also a hyperaemisation effect in skeletal muscle. This study has the objective to determine the effects of a nonivamide / nicoboxil cream on haemodynamics in skin and calf muscle via optical spectroscopy in the visible and near-infrared with a separation of changes for skin and muscle. Left and right calves of 14 healthy subjects were treated with a nonivamide / nicoboxil cream or mock administration, and cutaneous and muscle haemoglobin were measured using a combined NIRS / VIS sensor. The topical application of the cream increased the concentration of oxygenated haemoglobin and tissue oxygen saturation significantly in skin as well as in muscle of the treated legs already after 15 minutes, with stronger and faster effects in skin. In contrast, the change in deoxygenated haemoglobin was found to be small. The kinetic of all changes varied widely between the subjects. The found haemoglobin changes might explain the beneficial effect of hyperaemisation creams for the treatment of minor injuries.

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“…Data acquisition and on-line analysis of the spectra was programmed in LabView 7.1 (National Instruments Inc.) and an additional off-line data evaluation in MATLAB (Version R14; Mathworks Inc., USA). Details of the setup are given elsewhere [6,10]. Reflected light intensities I i (i = 1 -6) were corrected by spectra recorded with an integrating sphere I ref,I and converted into attenuation spectra…”

Section: Set-upmentioning

confidence: 99%

“…In a recent study of muscle oxygenation during an incremental cycling exercise under altitude conditions [6] we used a broad-band, spatially resolved approach (SRS) to measure muscle oxygenation and observed the before mentioned effect of ATT. The method applied is potentially able to calculate absolute haemoglobin concentrations (oxy-Hb, and deoxyHb) as well as tissue oxygen saturation (SO 2 ) rather than just changes in oxygenation [7 -9], but the lipid layer does obstruct this measurement.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic measurement of adipose tissue thickness and comparison with ultrasound imaging

2007

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Near-infrared spectroscopy (NIRS) is widely applied for applications monitoring skeletal muscle oxygenation. However, this method is obstructed by the subcutaneous adipose tissue thickness (ATT) which might vary between < 1 mm to more than 12 mm. Though diffuse optical imaging can be applied to measure ATT, the objective here is to get this measure from spectroscopic data of a single source-detector distance. For the measurement of the optical lipid signal we used a broad band spatially resolved system (SRS), which is based on measurements of the wavelength dependence of the attenuation A for source detector distances ρ between 29 mm and 39 mm. Ultrasound images served as an anatomical reference of the lipid layer. The measurements were taken on 5 different muscle groups of 20 healthy volunteers, each for left and right limbs, e.g. vastus medialis, vastus lateralis and gastrocnemius muscle on the leg and ventral forearm muscles and biceps brachii muscle on the arm. Different analysis strategies were tested for the best calculation of ATT. There is a good non-linear correlation between optical lipid signal and ultrasound data, with an overall error in ATT prediction of about 0.5 mm. This finding is supported experimentally by additional MRI measurements as well as a multi-layer Monte Carlo (MC) model. Based on this data of the ATT thickness, a newly developed algorithm which exploits the wavelength dependence of the slope in attenuation with respect to source-detector distance and MC simulation for these parameters as a function of absorption and scattering coefficients delivers a considerably better fit of reflectance spectra when fitting haemoglobin concentrations. Implications for the monitoring of muscle oxygen saturation are discussed.

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Muscle Oxygenation during Exercise under Hypoxic Conditions Assessed by Spatial-Resolved Broadband NIR Spectroscopy

Cited by 5 publications

References 0 publications

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream

Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream

Spectroscopic measurement of adipose tissue thickness and comparison with ultrasound imaging

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