Muscle metabolism during and after strenuous intermittent running

Näveri, H; Rehunen, S.; Kuoppasalmi, Kimmo; Tulikoura, I; Härkönen, Matti

doi:10.3109/00365517809108431

Cited by 38 publications

(11 citation statements)

References 19 publications

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“…In some runners the increased CPK was certainly great enough to be associated with rhabdomyolysis and possibly mild renal insufficiency, although renal function was not measured. We did not question the runners about extremity pain at that time, but our finding is consistent with their subjective complaints and the degree of muscle damage as described by others [17,33]. The modestly elevated serum CPK concentration at baseline most likely reflected minor muscle damage that occurred during training.…”

Section: Discussionsupporting

confidence: 86%

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The Effect of Arginine or Glycine Supplementation on Gastrointestinal Function, Muscle Injury, Serum Amino Acid Concentrations and Performance During a Marathon Run

Buchman

O’Brien

et al. 1999

Int J Sports Med

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Gastrointestinal bleeding and increased intestinal permeability have been observed in marathon runners. We sought to determine if L-arginine would be useful for prevention of these complications. Twenty-three runners were randomized to receive L-arginine (A) or glycine (placebo) (G), 10 grams 3 times daily for 14 days prior to the 1997 Houston-Methodist Marathon. Serum, stool hemoccults and lactulose:mannitol permeabilities were obtained at baseline, immediately after completion of the marathon and approximately 48 hours later. Runners rated their symptoms of nausea and vomiting, belching and indigestion, abdominal pain and bloating, diarrhea, and extremity pain on a 1-5 scale of increasing severity. The L:M was unchanged in either group during the three collections. Occult bleeding occurred in 8%/20% in A and G groups, respectively, p = NS) immediately post-marathon. No runners had occult bleeding 48 hours post-race. Gastrointestinal symptom scores were minimal to nonexistent. Extremity pain scores were similar for groups A and G (2.1+/-1.4 and 2.8+/-1.6, respectively, (p = NS). Fluid intake was similar between both groups (1875+/-1547 vs. 1506+/-970 ml, p = NS). Serum amylase was normal at baseline and remained virtually unchanged. Serum lipase was normal at baseline and immediately post-race in both groups, but increased at 48 hours post-race (82.2+/-34.3 to 121.5+/-53.3 mg/dl [A], p = 0.02 and 114.3+/-55.7 to 181.9+/-162.2 mg/dl [G], p = 0.09). CPK increased significantly and similarly in both groups immediately post-race, and even more dramatically 48 hours post-race (130.3+/-130.8 to 738.8+/-902.9, p = 0.007 to 1966.5+/-3.166.0 mg/dl [A] and 140.9+/-77.9 to 863.0+/-772.3, p = 0.003 to 5619+/-10636.8mg/dl [G]). Modest post-race decreases were seen in most serum amino acids in both groups. Finish times were longer than predicted (23+/-21 and 9+/-7 min for A and G groups, respectively, p = 0.049). Our study failed to show a clear benefit of arginine supplementation for the prevention of intestinal ischemia/reperfusion injury associated with endurance running, but either a detrimental affect on performance with arginine, or enhanced performance with glycine. Skeletal muscle injury was unaffected by arginine or glycine supplementation. The delayed increase in serum lipase suggests mild pancreatic injury, affected by either arginine or glycine supplementation.

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Section: Discussionsupporting

confidence: 86%

“…We used serum CPK as a surrogate marker for muscle injury [5,16,17,33,50]. CPK was significantly increased at the end of the race.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Arginine or Glycine Supplementation on Gastrointestinal Function, Muscle Injury, Serum Amino Acid Concentrations and Performance During a Marathon Run

Buchman

O’Brien

et al. 1999

Int J Sports Med

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“…Acid extracts for measurement of blood lactate and for determination of muscle ATP, creatine phosphate, creatine and lactate in mixed muscle were made as described by Naveri et al [21]. These parameters were determined fluorometrically with a Farrand model A-4 fluorometer by pyridine nucleotide-linked enzymatic methods according to Lowry and Passonneau [19].…”

Section: Materials a N D Methodsmentioning

confidence: 99%

High-energy phosphate compounds during exercise in human slow-twitch and fast-twitch muscle fibres

Rehunen

Näveri

Kuoppasalmi

et al. 1982

Scand J Clin Lab Invest

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Rehunen, S., Naveri, H., Kuoppasalmi, K. & Harkonen, M. High-energy phosphate compounds during exercise in human slow-twitch and fast-twitch muscle fibres. Scand. J. clin. Lab. Invest. 42, 499-506, 1982.Concentrations of ATP and creatine phosphate, the high-energy phosphates, were investigated in slow-twitch (ST) and fast-twitch (FT) muscle fibres in sprinters and in long-distance runners at rest, during light sprinting exercise and during an extremely exhaustive running exercise. At rest the long-distance runners had significantly (P

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“…The slow-component of PCr resynthesis may, partly be due to the slow recovery of muscle pH after high-intensity exercise Naveri, Rehunen, Kuoppasalmi, Tulikoura and Harkonen, 1978). Furthermore, as most of the Pi bound up in the formation of organic phosphates during exercise would have been derived partly from the breakdown of PCr, it is reasonable to suggest that PCr resynthesis during recovery is also linked to the decay of these phosphates.…”

Section: Resynthesis Of Phosphoryicreatinementioning

confidence: 97%

Human muscle metabolism during intermittent maximal exercise

Gaitanos

Williams

Boobis

et al. 1993

Journal of Applied Physiology

744

591

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Eight male subjects volunteered to take part in this study. The exercise protocol consisted of ten 6-s maximal sprints with 30 s of recovery between each sprint on a cycle ergometer. Needle biopsy samples were taken from the vastus lateralis muscle before and after the first sprint and 10 s before and immediately after the tenth sprint. The energy required to sustain the high mean power output (MPO) that was generated over the first 6-s sprint (870.0 +/- 159.2 W) was provided by an equal contribution from phosphocreatine (PCr) degradation and anaerobic glycolysis. Indeed, within the first 6-s bout of maximal exercise PCr concentration had fallen by 57% and muscle lactate concentration had increased to 28.6 mmol/kg dry wt, confirming significant glycolytic activity. However, in the tenth sprint there was no change in muscle lactate concentration even though MPO was reduced only to 73% of that generated in the first sprint. This reduced glycogenolysis occurred despite the high plasma epinephrine concentration of 5.1 +/- 1.5 nmol/l after sprint 9. In face of a considerable reduction in the contribution of anaerobic glycogenolysis to ATP production, it was suggested that, during the last sprint, power output was supported by energy that was mainly derived from PCr degradation and an increased aerobic metabolism.

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Muscle metabolism during and after strenuous intermittent running

Cited by 38 publications

References 19 publications

The Effect of Arginine or Glycine Supplementation on Gastrointestinal Function, Muscle Injury, Serum Amino Acid Concentrations and Performance During a Marathon Run

The Effect of Arginine or Glycine Supplementation on Gastrointestinal Function, Muscle Injury, Serum Amino Acid Concentrations and Performance During a Marathon Run

High-energy phosphate compounds during exercise in human slow-twitch and fast-twitch muscle fibres

Human muscle metabolism during intermittent maximal exercise

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