Muscle insulin-like growth factor status, body composition, and functional capacity in hemodialysis patients

Macdonald, Jamie; Phanish, Mysore; Marcora, Samuele Maria; Jibani, Mahdi; Bloodworth, L L; Holly, Jeff M.P.; Lemmey, Andrew

doi:10.1016/j.jrn.2004.08.001

Cited by 24 publications

(9 citation statements)

References 10 publications

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“…Platelet derived growth factor (PDGF) D concentrations pre-HD trended higher than control levels and were signi cantly elevated in post-HD plasma, while neither pre-nor post-HD PDGFB levels signi cantly differed from controls. In agreement with prior studies [30][31][32][33] , in ammation and cardiovascular stress measured uniformly higher in dialysis patients, shown by N-Terminal Prohormone of Brain Natriuretic Peptide (NTpBNP), C-reactive protein (CRP), tumor necrosis factor receptor 1 (TNFR1), and interleukin 1 beta (IL1β) as shown in Fig. 1C.…”

Section: Resultssupporting

confidence: 92%

“…Many plasma biomarker measurements reported in this study mirror prior ndings in HD patients demonstrating effects of uremia 10,18,19,22 , acute in ammatory response [30][31][32] , cardiovascular risk through mechanical strain and oxidative stress 33,44 , coagulative dysfunction 26 , and microvascular damage and systemic brosis 28,29,[34][35][36][37][38]45 . Comparison of these measurements to prescribed dialysis metrics and quantitative platelet characterization yield novel insights into a circulatory environment in HD patients that is characterized by profound shifts in ECM homeostasis, microvascular damage, and platelet function.…”

Section: Discussionsupporting

confidence: 76%

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Hemodialysis Exacerbates Proteolytic Imbalance and Pro-fibrotic Platelet Dysfunction

Velasquez-Mao

Velasquez

Hui

et al. 2021

Preprint

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Multi-organ fibrosis among end stage renal disease (ESRD) patients cannot be explained by uremia alone. Despite mitigation of thrombosis during hemodialysis (HD), subsequent platelet dysfunction and tissue dysregulation are less understood. We comprehensively profiled plasma and platelets from ESRD patients before and after HD to examine HD-modulation of platelets beyond thrombotic activation. Basal plasma levels of proteolytic regulators and fibrotic factors were elevated in ESRD patients compared to healthy controls, with isoform-specific changes during HD. Platelet lysate (PL) RNA transcripts for growth and coagulative factors were elevated post-HD, with upregulation correlated to HD vintage. Platelet secretome correlations to plasma factors reveal acutely induced pro-fibrotic platelet phenotypes in ESRD patients during HD characterized by preferentially enhanced proteolytic enzyme translation and secretion, platelet contribution to inflammatory response, and increasing platelet dysfunction with blood flow rate (BFR) and Vintage. Compensatory mechanisms of increased platelet growth factor synthesis with acute plasma matrix metalloproteinase (MMP) and tissue inhibitor of MMPs (TIMP) increases show short-term mode-switching between dialysis sessions leading to long-term pro-fibrotic bias. Chronic pro-fibrotic adaptation of platelet synthesis were observed through changes in alpha-granule- and lysosome-filling behaviors. We conclude that chronic and acute platelet responses to HD contribute to a pro-fibrotic milieu in ESRD.

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Section: Resultssupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

Hemodialysis Exacerbates Proteolytic Imbalance and Pro-fibrotic Platelet Dysfunction

Velasquez-Mao

Velasquez

Hui

et al. 2021

Preprint

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“…For sit to stand scores, a significantly greater change in healthy PRET compared to healthy SHAM was observed (mean difference [95 % CI]: 5 [3–8] units; p = 0.005; d = 0.2). In contrast, in the HD patients, the response to PRET was not different to SHAM (mean difference [95 % CI]: 1 [−1 to 4] units; p = 0.3; d = 0.3).…”

Section: Resultsmentioning

confidence: 99%

“…Muscle wasting in this population is a noteworthy problem as it independently predicts morbidity and mortality [6]. Strong positive correlations have been revealed between muscle quantity and strength, oxygen extraction at the muscle and functional capacity in HD patients [2, 3, 7, 8], suggesting that muscle wasting also reduces physical functioning. Thus, muscle wasting indirectly affects quality of life (QoL).…”

Section: Introductionmentioning

confidence: 99%

Anabolic exercise in haemodialysis patients: a randomised controlled pilot study

Kirkman

Mullins

Junglee

et al. 2014

J cachexia sarcopenia muscle

Self Cite

143

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BackgroundThe anabolic response to progressive resistance exercise training (PRET) in haemodialysis patients is unclear. This pilot efficacy study aimed to determine whether high-intensity intradialytic PRET could reverse atrophy and consequently improve strength and physical function in haemodialysis patients. A second aim was to compare any anabolic response to that of healthy participants completing the same program.MethodsIn a single blind controlled study, 23 haemodialysis patients and 9 healthy individuals were randomly allocated to PRET or an attention control (SHAM) group. PRET completed high-intensity exercise leg extensions using novel equipment. SHAM completed low-intensity lower body stretching activities using ultra light resistance bands. Exercises were completed thrice weekly for 12 weeks, during dialysis in the haemodialysis patients. Outcomes included knee extensor muscle volume by magnetic resonance imaging, knee extensor strength by isometric dynamometer and lower body tests of physical function. Data were analysed by a per protocol method using between-group comparisons.ResultsPRET elicited a statistically and clinically significant anabolic response in haemodialysis patients (PRET—SHAM, mean difference [95 % CI]: 193[63 to 324] cm3) that was very similar to the response in healthy participants (PRET—SHAM, 169[−41 to 379] cm3). PRET increased strength in both haemodialysis patients and healthy participants. In contrast, PRET only enhanced lower body functional capacity in the healthy participants.ConclusionsIntradialytic PRET elicited a normal anabolic and strength response in haemodialysis patients. The lack of a change in functional capacity was surprising and warrants further investigation.

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“…IGF-1 has been shown to be negatively correlated with IGFBP-1 in both peritoneal and hemodialysis patients [18]. Low muscle IGF-I levels have also been demonstrated in hemodialysis patients [19].…”

Section: Introductionmentioning

confidence: 99%

Insulin–glucose infusion given before hemodialysis increases IGF-I in type 2 diabetes patients with chronic kidney disease

Lindgren

Jacobson

Brismar

2010

Growth Hormone & IGF Research

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Muscle insulin-like growth factor status, body composition, and functional capacity in hemodialysis patients

Cited by 24 publications

References 10 publications

Hemodialysis Exacerbates Proteolytic Imbalance and Pro-fibrotic Platelet Dysfunction

Hemodialysis Exacerbates Proteolytic Imbalance and Pro-fibrotic Platelet Dysfunction

Anabolic exercise in haemodialysis patients: a randomised controlled pilot study

Insulin–glucose infusion given before hemodialysis increases IGF-I in type 2 diabetes patients with chronic kidney disease

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