Muscle insulin-like growth factor status, body composition, and functional capacity in hemodialysis patients

Macdonald, Jamie; Phanish, Mysore K.; Marcora, Samuele; Jibani, Mahdi; Bloodworth, L L; Holly, Jeffrey M P; Lemmey, Andrew

doi:10.1016/s1051-2276(04)00136-0

Cited by 25 publications

(37 citation statements)

References 11 publications

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“…Similar to our findings, MacDonald et al 15 described normal serum IGF-I and IGFBP-3 in 17 MHD patients; however, muscle IGF-I was low in their patients, whereas we observed increased muscle IGF-I that rose further with exercise (Table 4). The low muscle IGF-I may have been due to the wasted state of their patients, as indicated by anthropometry and body composition measurements, whereas our patients did not seem wasted.…”

Section: Discussionsupporting

confidence: 91%

Exercise in Maintenance Hemodialysis Patients Induces Transcriptional Changes in Genes Favoring Anabolic Muscle

Kopple¹,

Wang²,

Casaburi³

et al. 2007

Journal of the American Society of Nephrology

141

127

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Exercise training increases exercise capacity of maintenance hemodialysis patients, but the cellular mechanisms responsible for this effect are unclear. We studied the effects of different forms of exercise training (endurance, strength, or a combination where patients underwent about one-half each of the endurance and strength training of the first two groups) on mRNA levels of genes in muscle that may contribute to increased exercise capacity. Before exercise training, muscle mRNA of insulin-like growth factor (IGF)-IEa, IGF-I receptor, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 were lower in hemodialysis patients than normal controls. After approximately 21 weeks of exercise training, muscle mRNA increased significantly for all of these genes, as well as for IGF-IEc. Muscle mRNA for myostatin, a protein that inhibits skeletal muscle protein synthesis and muscle hypertrophy, decreased. The responses of mRNA to the different types of exercise training generally showed similar significant changes or trends. Muscle IGF-I protein also increased with exercise. Anthropometry, but not dual energy x-ray absorptiometry or bioelectrical impedance, showed a decrease in body fat and an increase in fat-free mass. In conclusion, exercise training in hemodialysis patients induces changes in skeletal muscle mRNA and increases muscle IGF-I protein, which may promote protein anabolism.

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Section: Discussionsupporting

confidence: 91%

Exercise in Maintenance Hemodialysis Patients Induces Transcriptional Changes in Genes Favoring Anabolic Muscle

Kopple¹,

Wang²,

Casaburi³

et al. 2007

Journal of the American Society of Nephrology

141

127

View full text Add to dashboard Cite

show abstract

“…In this study diminished muscle levels of insulin-like growth factor-I (mIGF-I) were identified in our RA patients. This finding is consistent with reports of reduced mIGF-I levels in other conditions characterised by muscle wasting: chronic heart failure (CHF) (Hambrecht et al, 2005), chronic obstructive pulmonary disease (COPD) (Vogiatzis et al, 2007), chronic renal failure (Macdonald et al, 2004(Macdonald et al, , 2005, and advanced aging (Fiatarone Singh et al, 1999); and with the proposed role of mIGF-I in regulating the maintenance of adult skeletal muscle (Adams, 2002). Following 24 weeks PRT, along with muscle hypertrophy, mIGF-I levels were observed to increase 50% in our RA patients.…”

Section: Impact On Mechanisms Of Rheumatoid Cachexiasupporting

confidence: 92%

Resistance Training for Patients with Rheumatoid Arthritis: Effects on Disability, Rheumatoid Cachexia, and Osteoporosis; and Recommendations for Prescription

Lemmey¹

2012

Rheumatoid Arthritis - Treatment

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“…The increase in handgrip strength in the oxymetholonetreated group was consistent with the foregoing findings that suggest an increase in muscle mass. Muscle strength is usually directly correlated with muscle mass (22)(23)(24), and therefore, if muscle mass increased, one would expect there to be an increase in strength. Moreover, the oxymetholonetreated patients described an increase in physical performance on their SF-36 forms.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Anabolic Steroid on Muscle Strength and Muscle Growth in Hemodialysis Patients

Supasyndh

Satirapoj

Aramwit

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Sarcopenia is common in hemodialysis patients. This study examined whether the anabolic steroid oxymetholone improves muscle mass and handgrip strength in hemodialysis patients and possible mechanisms that might engender such changes.Design, setting, participants, & measurements Forty-three eligible hemodialysis patients were randomly assigned to ingest oxymetholone or placebo for 24 weeks. Body composition, handgrip strength, and quality of life were measured during the study. Muscle biopsies were performed and analyzed for mRNA levels for myostatin, IGF-I, IGF binding proteins, and myosin heavy chains and protein expression. Muscle fiber types and diameter were assessed by reduced nicotinamide-adenine dinucleotide staining.Results There was a significantly greater increase in fat-free mass and handgrip strength and decrease in fat mass in the oxymetholone compared with the placebo group. Moreover, compared with baseline values, patients given oxymetholone exhibited an increase in fat-free mass, handgrip strength, physical functioning scores, and type I muscle fiber cross-sectional area and a decrease in fat mass, whereas patients receiving placebo did not undergo changes. There was a significantly greater increase in muscle mRNA levels for myosin heavy chain 23, IGF-I, and IGF-II receptor with oxymetholone treatment than placebo. Liver enzyme rose significantly in the oxymetholone group, but the number of values greater than three times the upper limit of normal were not different between these groups. ConclusionsIn hemodialysis patients, ingesting oxymetholone was associated with an increase in fat-free mass, handgrip strength, and muscle mRNA levels for several growth factors and a decrease in fat mass, but it also induced liver injury.

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Muscle insulin-like growth factor status, body composition, and functional capacity in hemodialysis patients

Cited by 25 publications

References 11 publications

Exercise in Maintenance Hemodialysis Patients Induces Transcriptional Changes in Genes Favoring Anabolic Muscle

Exercise in Maintenance Hemodialysis Patients Induces Transcriptional Changes in Genes Favoring Anabolic Muscle

Resistance Training for Patients with Rheumatoid Arthritis: Effects on Disability, Rheumatoid Cachexia, and Osteoporosis; and Recommendations for Prescription

Effect of Oral Anabolic Steroid on Muscle Strength and Muscle Growth in Hemodialysis Patients

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