Muscle fibre type changes in hypothyroid myopathy.

McKeran, R O; Slavin, G; Andrews, Tony; Ward, Paul; Mair, W.

doi:10.1136/jcp.28.8.659

Cited by 85 publications

(44 citation statements)

References 19 publications

(14 reference statements)

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“…Should the vastus lateralis muscle 3-methylhistidine content prove to be representative of the mean concentration in the body's skeletal muscle, in both health and disease, future studies could use a figure obtained from the individual subject by percutaneous needle biopsy of muscle. Repeated biopsies would be possible because this technique is relatively atraumatic, and leaves a minimal residual scar (Edwards, 1971;McKeran et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.

McKeran¹,

Halliday²,

Purkiss³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.

McKeran¹,

Halliday²,

Purkiss³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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“…There is histological change being atrophy of type I1 fibres and hypertrophy of type 1 fibres [19], with a shift towards the physiology of red muscle [20]. Decreased activities of mitochondria1 enzymes and in the enzymes involved in glucose metabolism have been reported in hypothyroidism .…”

Section: Discussionmentioning

confidence: 99%

Forearm muscle metabolism in primary hypothyroidism

Harris

Walker

Clark

et al. 1993

Eur J Clin Investigation

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Abstract. Thyrotoxicosis is associated with increased skeletal muscle glucose metabolism and lipid oxidation in the fasted state. Conversely, in hypothyroidism, glucose metabolism is reduced. The present study has assessed in patients the effects of chronic thyroid hormone deficiency, on insulin-stimulated skeletal muscle metabolism, using a combination of the forearm and hyperinsulinaemic euglycaemic clamp techniques. Seven female patients presenting with primary auto-immune hypothyroidism were studied at presentation and 4-9 months after being rendered biochemically euthyroid. No significant differences were demonstrated between the hypothroid and euthyroid states in forearm muscle blood flow, or in glucose or lipid metabolism.

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“…Type I1 fiber atrophy is one of the most common abnormalities associated with muscle disease [28] and has been seen in man and dogs with neoplastic disease, Cushing's syndrome, steroid myopathy, hypothyroidism, disuse, and denervation [6,11,22,29,39,41,441. None of these conditions were present in our dogs.…”

Section: Discussionmentioning

confidence: 99%

Observations on Normal Skeletal Muscle of Mature Dogs: A Cytochemical, Histochemical, and Morphometric Study

1982

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Abstract. Cytochemical, histochemical, and morphometric features of skeletal muscle were evaluated in 140 specimens from five appendicular muscles of 28 dogs which were free of neuromuscular disease. Dogs ranged from six months to 15 years of age. Evidence of degeneration and regeneration, cell reactions and architectural change was found but with an incidence of less than 1% of the total myofiber population in any muscle. The number of fibers with internal nuclei never exceeded 1%. The only changes that appeared to be agerelated were fiber size variation associated with the presence of small angular type IIA fibers in muscles of dogs seven years of age and older. Percentages of type I, type IIA, and type IIC fibers remained relatively constant in the various muscles in the age range examined. Type I fibers predominated in medial head of triceps brachii and superficial digital flexor muscles, whereas type IIA fibers were more numerous in biceps femoris and long head of triceps brachii muscles. An approximately equal ratio was found in gastrocranius muscles. In any given muscle, type IIC fibers represented less than 2% of the fibers. Statistically significant differences were found in values for fiber size between groups of dogs weighing more than (mean diameter range = 40 to 50 pm) and less than (mean diameter range = 30 to 40 pm) 15 kilograms.

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Muscle fibre type changes in hypothyroid myopathy.

Cited by 85 publications

References 19 publications

3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.

3-Methylhistidine excretion as an index of myofibrillar protein catabolism in neuromuscular disease.

Forearm muscle metabolism in primary hypothyroidism

Observations on Normal Skeletal Muscle of Mature Dogs: A Cytochemical, Histochemical, and Morphometric Study

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