Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

Place, Nicolas; Yamada, Takashi; Bruton, Joseph D.; Westerblad, Håkan

doi:10.1007/s00421-010-1480-0

Cited by 150 publications

(142 citation statements)

References 128 publications

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“…100, 110, 120 and 130 RPM). Due to the muscle biopsy extraction, there was a delay of 20 min from termination of prolonged cycling exercise until determination of W peak and it is thus very likely that the observed reduction in PPO was, in reality, higher immediately following exercise (36,38). Further, with the delay between termination of exercise and biopsy, the observed impairment in maximal power generating capacity can probably not be explained by muscle depolarization and/or metabolic changes except from alterations in glycogen contents (decrease in ATP and PCr, and increased P i , H + or Cr), which would be normalized within 20 min recovery.…”

Section: Figure 3 Near Herementioning

confidence: 99%

Muscle Glycogen Content Modifies SR Ca2+ Release Rate in Elite Endurance Athletes

Gejl

Hvid

Frandsen

et al. 2014

Medicine &Amp; Science in Sports &Amp; Exercise

103

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Section: Figure 3 Near Herementioning

confidence: 99%

Muscle Glycogen Content Modifies SR Ca2+ Release Rate in Elite Endurance Athletes

Gejl

Hvid

Frandsen

et al. 2014

Medicine &Amp; Science in Sports &Amp; Exercise

103

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“…As M-wave changes were quite small compared with the extent of peak twitch and doublet reductions, we argue that the force decline was likely caused by alterations occurring beyond the sarcolemma (11). The decrease in peak twitch, PS100, and PS10 amplitudes may therefore be related to altered Ca 2ϩ handling (1,9,62).…”

Section: Origin Of Mvc Force Lossmentioning

confidence: 99%

Comparison of neuromuscular adjustments associated with sustained isometric contractions of four different muscle groups

Neyroud

Rüttimann

Mannion

et al. 2013

Journal of Applied Physiology

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Neyroud D, Rüttimann J, Mannion AF, Millet GY, Maffiuletti NA, Kayser B, Place N. Comparison of neuromuscular adjustments associated with sustained isometric contractions of four different muscle groups. J Appl Physiol 114: 1426 -1434, 2013. First published March 7, 2013 doi:10.1152/japplphysiol.01539.2012.-The extent and characteristics of muscle fatigue of different muscle groups when subjected to a similar fatiguing task may differ. Thirteen healthy young men performed sustained contractions at 50% maximal voluntary contraction (MVC) force until task failure, with four different muscle groups, over two sessions. Per session, one upper limb and one lower limb muscle group were tested (knee extensors and thumb adductor, or plantar and elbow flexors). Changes in voluntary activation level and contractile properties were derived from doublet responses evoked during and after MVCs before and after exercise. Time to task failure differed (P Ͻ 0.05) between muscle groups (220 Ϯ 64 s for plantar flexors, 114 Ϯ 27 s for thumb adductor, 77 Ϯ 25 s for knee extensors, and 72 Ϯ 14 s for elbow flexors). MVC force loss immediately after voluntary task failure was similar (Ϫ30 Ϯ 11% for plantar flexors, Ϫ37 Ϯ 13% for thumb adductor, Ϫ34 Ϯ 15% for knee extensors, and Ϫ40 Ϯ 12% for elbow flexors, P Ͼ 0.05). Voluntary activation was decreased for plantar flexors only (from 95 Ϯ 5% to 82 Ϯ 9%, P Ͻ 0.05). Potentiated evoked doublet amplitude was more depressed for upper limb muscles (Ϫ59.3 Ϯ 14.7% for elbow flexors and Ϫ60.1 Ϯ 24.1% for thumb adductor, P Ͻ 0.05) than for knee extensors (Ϫ28 Ϯ 15%, P Ͻ 0.05); no reduction was found in plantar flexors (Ϫ7 Ϯ 12%, P Ͼ 0.05). In conclusion, despite different times to task failure when sustaining an isometric contraction at 50% MVC force for as long as possible, diverse muscle groups present similar loss of MVC force after task failure. Thus the extent of muscle fatigue is not affected by time to task failure, whereas this latter determines the etiology of fatigue. endurance time; fatigue; maximal voluntary contraction; contractile properties; surface electromyography TIME TO TASK FAILURE of a sustained submaximal isometric contraction (i.e., endurance time, ET) depends on physiological factors such as relative force level (30, 35), muscle fiber type composition (16,51,77), muscular activation strategy (6,19,38), muscle size (36), and length (54, 58) but also depends on psychological factors such as motivation, mood, and expectation (24). Whereas the task dependency of ET is well documented (23,25,26), little is known about muscle fatigue characteristics induced by a given task sustained until failure in different muscle groups, in the same individuals. Frey-Law and Avin (28) suggested that no single fatigue model applies to all muscles. Their meta-analysis showed large differences in ET depending on the muscle group considered, especially at low contraction intensities. However, it is unknown whether the extent of maximal voluntary contraction (MVC) force loss immediately after task ...

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“…Although many forms of mechanical stimuli occur physiologically, the most well studied are the responses of cells to cyclic stretch to specifically simulate the contraction/relaxation cycles that occur within the cardiovascular and pulmonary systems (14)(15)(16)(17). However, sustained stretch also commonly occurs in tissues-e.g., when injury-induced swelling causes local hydrostatic pressure increase (18), in long-term blood pressure increase (16,19), during prolonged muscle contraction (20,21), or when the bladder retains large volume of urine (22,23). In such situations, tissue stretching may last for minutes or hours without regular relaxation intervals, and likely generates cellular responses that lead to tissue adaptation.…”

mentioning

confidence: 99%

Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover

Chen

Pasapera

Koretsky

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Cells are mechanosensitive to extracellular matrix (ECM) deformation, which can be caused by muscle contraction or changes in hydrostatic pressure. Focal adhesions (FAs) mediate the linkage between the cell and the ECM and initiate mechanically stimulated signaling events. We developed a stretching apparatus in which cells grown on fibronectin-coated elastic substrates can be stretched and imaged live to study how FAs dynamically respond to ECM deformation. Human bone osteosarcoma epithelial cell line U2OS was transfected with GFP-paxillin as an FA marker and subjected to sustained uniaxial stretching. Two responses at different timescales were observed: rapid FA growth within seconds after stretching, and delayed FA disassembly and loss of cell polarity that occurred over tens of minutes. Rapid FA growth occurred in all cells; however, delayed responses to stretch occurred in an orientation-specific manner, specifically in cells with their long axes perpendicular to the stretching direction, but not in cells with their long axes parallel to stretch. Pharmacological treatments demonstrated that FA kinase (FAK) promotes but Src inhibits rapid FA growth, whereas FAK, Src, and calpain 2 all contribute to delayed FA disassembly and loss of polarity in cells perpendicular to stretching. Immunostaining for phospho-FAK after stretching revealed that FAK activation was maximal at 5 s after stretching, specifically in FAs oriented perpendicular to stretch. We hypothesize that orientation-specific activation of strain/stress-sensitive proteins in FAs upstream to FAK and Src promote orientation-specific responses in FA growth and disassembly that mediate polarity rearrangement in response to sustained stretch.mechanosensing | integrin | tissue mechanics

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Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres

Cited by 150 publications

References 128 publications

Muscle Glycogen Content Modifies SR Ca2+ Release Rate in Elite Endurance Athletes

Muscle Glycogen Content Modifies SR Ca2+ Release Rate in Elite Endurance Athletes

Comparison of neuromuscular adjustments associated with sustained isometric contractions of four different muscle groups

Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover

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