Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson’s Disease

Pereira, Vinícius Alota Ignácio; Barbieri, Fábio Augusto; Zagatto, Alessandro Moura; Santos, Paulo Cezar Rocha dos; Simieli, Lucas; Barbieri, Ricardo Augusto; Carpes, Felipe P.; Gobbi, Lilian Teresa Bucken

doi:10.14336/ad.2018.0203

Cited by 11 publications

(12 citation statements)

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“…Forty studies6,7,22–59 assessed MMF in PwPD versus HC (study characteristics are available in Supplemental Digital Content 2 Table 1d, available at: http://links.lww.com/JNPT/A404). Muscle strength was assessed in 37 studies6,7,22–37,39–43,45–47,49–59 (see Table, Supplemental Digital Content 3, available at: http://links.lww.com/JNPT/A406) while 12 studies reported RFD25,26,29 (p) ,31,38,43,44,46,50,54,57,58 and 1 study48 reported power outcomes (Table 1). Study sample sizes ranged from 6 to 61 PwPD and from 6 to 37 HC, summing to a total of 718 PwPD and 633 HC.…”

Section: Resultsmentioning

confidence: 99%

“…com/JNPT/A404). Muscle strength was assessed in 37 studies 6,7,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][39][40][41][42][43][45][46][47][49][50][51][52][53][54][55][56][57][58][59] (see Table, Supplemental Digital Content 3, available at: http://links.lww.com/JNPT/A406) while 12 studies reported RFD 25,26,29(p),31,38,43,44,46,50,54,57,58 and 1 study 48 reported power outcomes (Table 1). Study sample sizes ranged from 6 to 61 PwPD and from 6 to 37 HC, summing to a total of 718 PwPD and 633 HC.…”

Section: Aim 2: Comparison Of Mechanical Muscle Function In Pwpd Vers...mentioning

confidence: 99%

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Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis

Gamborg

Hvid²,

Thrue³

et al. 2022

Journal of Neurologic Physical Therapy

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Background and Purpose: No studies have synthesized the literature regarding mechanical muscle function (ie, strength, power, rate of force development [RFD]) in people with Parkinson disease (PD). Here, we aimed to expand our understanding of mechanical muscle function in people with PD (PwPD) by systematically reviewing (1) the psychometric properties of isokinetic/isometric dynamometry in PD, (2) the literature comparing mechanical muscle function in PwPD with healthy controls (HC), and (3) reported associations between muscle mechanical muscle function and functional capacity and/or disease severity. Methods: Systematic literature search in 6 databases. Included studies had to (1) enroll and report data on PwPD, (2) include assessment(s) of psychometric properties (ie, validity, reliability, responsiveness) of isokinetic/isometric dynamometry in PD, and/or (3) assess mechanical muscle function in both PwPD and HC using isokinetic/isometric dynamometry. Results: A total of 40 studies were included. Aim 1 studies (n = 2) showed high reliability for isometric dynamometry (hip-abductor/dorsiflexor/trunk flexor-extensor/handgrip: intraclass correlations coefficients range = 0.92-0.98). Aim 2 studies (n = 40) showed impaired mechanical muscle function (ie, strength, power, RFD) in PwPD compared with HC (effect sizes range = 0.52-1.89). Aim 3 studies (n = 11) showed weak-to-strong associations between overall and lower extremities muscle strength and functional capacity and/or disease severity outcomes (ie, Unified Parkinson Disease Rating Scale). Discussion and Conclusions: Sparse methodological evidence suggests high reliability when using dynamometry in PwPD. Muscle strength, power, and RFD are impaired in PwPD compared with HC. Muscle strength is associated with functional capacity and disease severity. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A403).

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Section: Resultsmentioning

confidence: 99%

Section: Aim 2: Comparison Of Mechanical Muscle Function In Pwpd Vers...mentioning

confidence: 99%

Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis

Gamborg

Hvid²,

Thrue³

et al. 2022

Journal of Neurologic Physical Therapy

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“…They can appear early in the course of PD, with increasing severity along with the progression of the disease. Furthermore, because of the disabling characteristics of these dysarthrias, approximately 70% of patents with PD suffer from worsening quality of life [11,32–37], such as reduced communication function [38,39], declined social contact [8,12] or increasing feelings of social isolation [40]. Thus, patients tend to start to paying attention to dysarthria in the mid to late stage rather than early in the disease course.…”

Section: Introductionmentioning

confidence: 99%

Lee Silverman Voice Treatment for dysarthria in patients with Parkinson’s disease: a systematic review and meta‐analysis

Yuan

Guo

Wei

et al. 2020

Euro J of Neurology

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Approximately 89% of patients with Parkinson’s disease (PD) suffer from dysarthria. Lee Silverman Voice Treatment (LSVT), a behavioral therapy, aims to improve speech and voice functions. The objective was to assess the effectiveness of LSVT compared with other/no speech interventions for dysarthria in patients with PD. Electronic databases, including PubMed, Embase and the Cochrane Library, were searched. The publication date of all included studies was before 6 March 2020. Only randomized controlled trials (RCTs) that evaluated the LSVT intervention compared with other/no speech intervention were considered. The data obtained from the included studies were described and the mean differences were calculated. Eight RCTs were included in this meta‐analysis comparing LSVT with other/no speech interventions. In the comparison of LSVT versus no intervention, vocal intensity for sustained ‘Ah’ phonation, reading the ‘Rainbow passage’, monologue and describing a picture increased by 8.87, 4.34, 3.25 and 3.31 dB, respectively, after 1 month of therapy. Compared with the respiratory therapy group, the LSVT group also showed significant improvement in vocal intensity for sustained ‘Ah’ phonation, reading the ‘Rainbow passage’ and monologue immediately after treatment (13.39, 6.66 and 3.19 dB). Positive improvement still existed after 24 months. There was no difference in the therapeutic effect between face‐to‐face and online LSVT. The effectiveness of LSVT for dysarthria in patients with PD was verified in these trials. However, future RCTs with sufficient participants are essential to evaluate the effectiveness of LSVT for dysarthria.

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“…For instance, Huang et al (12) reported more exercise-induced fatigue in PD than in the healthy controls after a protocol of isometric knee extension. Instead, in a recent investigation Alota Ignacio Pereira et al (25) revealed similar values of force isometric voluntary contractions, after a repeated sit-to-stand task to induce fatigue, in patients with mild to moderate PD and healthy controls. The results of our study, differently from the initial hypothesis, agree with this interesting finding of Alota Ignacio Pereira et al and reinforce the idea that NF may be independent of PD symptoms.…”

Section: Discussionmentioning

confidence: 92%

Evidence that Neuromuscular Fatigue Is not a Dogma in Patients with Parkinson’s Disease

Martignon

Laginestra

Giuriato

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose: Given the increased level of fatigue frequently reported by patients with Parkinson's disease (PD), this study investigated the interaction between central and peripheral components of neuromuscular fatigue (NF) in this population compared with healthy peers. Methods: Changes in maximal voluntary activation (ΔVA, central fatigue) and potentiated twitch force (ΔQ tw,pot , peripheral fatigue) pre-post exercise were determined via the interpolated twitch technique in 10 patients with PD and 10 healthy controls (CTRL) matched for age, sex, and physical activity. Pulmonary gas exchange, femoral blood flow, and quadriceps EMG were measured during a fatiguing exercise (85% of peak power output [PPO]). For a specific comparison, on another day, CTRL repeat the fatiguing test matching the time to failure (TTF) and PPO of PD. Results: At 85% of PPO (PD, 21 ± 7 W; CTRL, 37 ± 22 W), both groups have similar TTF (~5.9 min), pulmonary gas exchange, femoral blood flow, and EMG. After this exercise, the maximal voluntary contraction (MVC) force and Q twpot decreased equally in both groups (−16%, P = 0.483; −43%, P = 0.932), whereas VA decreased in PD compared with CTRL (−3.8% vs −1.1%, P = 0.040). At the same PPO and TTF of PD (21 W; 5.4 min), CTRL showed a constant drop in MVC, and Q twpot (−14%, P = 0.854; −39%, P = 0.540), instead VA decreased more in PD than in CTRL (−3.8% vs −0.7%, P = 0.028). Conclusions: In PD, central NF seems exacerbated by the fatiguing task which, however, does not alter peripheral fatigue. This, besides the TTF like CTRL, suggests that physical activity may limit NF and counterbalance PD-induced degeneration through peripheral adaptations. Key Words: MUSCLE DYSFUNCTION, NEUROMUSCULAR FATIGUE, PARKINSON'S DISEASE P arkinson's disease (PD) is a neurological disease with an increasing prevalence, affecting 1% of people older than 60 yr and 3% older than 80 yr worldwide (1). Motor symptoms, including bradykinesia, rigidity, resting tremor, and postural impairment are the cardinal features of PD (2). However, numerous nonmotor symptoms have been increasingly recognized as part of the clinical spectrum of PD and often can dominate the clinical presentation (2) Specifically, fatigue, defined as a subjective feeling of exhaustion, weariness, or increased sense of effort disproportioned to the actual performance, seems to be more pronounced in patients with PD and affects indeed almost 50% of patients (3,4). Arguably, neuromuscular fatigue (NF) is defined as the gradual reduction in the ability to exert muscle force or power during exercise and has central and peripheral components (5). Central fatigue describes the impairment of the neural drive to a muscle, whereas peripheral fatigue entails biochemical changes occurring at or distally to the neuromuscular junction (6). So far, the symptom of fatigue in PD has been evaluated through questionnaires or self-report (7), and only few studies have examined the neurophysiological components of NF with accurate methods in patients with PD (8) and, even le...

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Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson’s Disease

Cited by 11 publications

References 50 publications

Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis

Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis

Lee Silverman Voice Treatment for dysarthria in patients with Parkinson’s disease: a systematic review and meta‐analysis

Evidence that Neuromuscular Fatigue Is not a Dogma in Patients with Parkinson’s Disease

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