Muscle Diseases in Elders: A 10-Year Retrospective Study

Laguno, Montserrat; Miró, Òscar; Perea, Milagrosa; Picón, M.; Urbano-Márquez, Á; Grau, Josep M.

doi:10.1093/gerona/57.6.m378

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…Muscle biopsy is one of the most frequently used diagnostic procedures in the evaluation of inherited and acquired myopathies. However, there are few modern reports documenting the diagnostic yield and clinical utility of open muscle biopsy [1–9]. A review of pediatric patients undergoing muscle biopsy in 1999 found that a specific diagnosis was provided in 36% of cases [1].…”

Section: Introductionmentioning

confidence: 99%

Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility

Lai

Melli

Chang

et al. 2009

Euro J of Neurology

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Section: Introductionmentioning

confidence: 99%

Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility

Lai

Melli

Chang

et al. 2009

Euro J of Neurology

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“…Laguno et al (2002) studied muscle biopsies from 239 patients over 65 years and diagnosed specific myopathies in 36% of them. Most of the causes of myopathies were other than genetic, i.e., inflammatory myopathies and vasculitis being the most frequent.…”

Section: Discussionmentioning

confidence: 99%

“…They identified dystrophies or congenital myopathies in 9% and metabolic myopathies in 10% of the patients. Elderly patients showed more non-specific type 2 fiber atrophy and fewer normal muscle biopsies compared to younger patients (Laguno et al, 2002). This was also shown in a similar study by Lacomis et al (1993).…”

Section: Discussionmentioning

confidence: 99%

Borderlines between Sarcopenia and Mild Late-Onset Muscle Disease

Palmio

Udd

2014

Front. Aging Neurosci.

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Numerous natural or disease-related alterations occur in different tissues of the body with advancing age. Sarcopenia is defined as age-related decrease of muscle mass and strength beginning in mid-adulthood and accelerating in people older than 60 years. Pathophysiology of sarcopenia involves both neural and muscle dependent mechanisms and is enhanced by multiple factors. Aged muscles show loss in fiber number, fiber atrophy, and gradual increase in the number of ragged red fibers and cytochrome c oxidase-negative fibers. Generalized loss of muscle tissue and increased amount of intramuscular fat are seen on muscle imaging. However, the degree of these changes varies greatly between individuals, and the distinction between normal age-related weakening of muscle strength and clinically significant muscle disease is not always obvious. Because some of the genetic myopathies can present at a very old age and be mild in severity, the correct diagnosis is easily missed. We highlight this difficult borderline zone between sarcopenia and muscle disease by two examples: LGMD1D and myotonic dystrophy type 2. Muscle magnetic resonance imaging (MRI) is a useful tool to help differentiate myopathies from sarcopenia and to reach the correct diagnosis also in the elderly.

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“…Stwierdzenie obecnooeci w biopsji miêoenia rimmed vacuoles i palisadowanych wtrêtów wewn¹trz - [12]. Jedno z czêstszych wskazañ do wykonania biopsji miêoenia to podejrzenie wystêpowania miopatii zapalnej [13,14]. Biopsja jest szczególnie przydatna w ró¿nicowaniu pomiêdzy zapaleniem wielomiêoeniowym a wtrêtowym zapaleniem miêoeni.…”

Section: Cav3/kaweolina-3/adunclassified

Rola biopsji mięśnia szkieletowego w diagnostyce chorób nerwowo-mięśniowych

Nadaj‐Pakleza

Kierdaszuk

Kamińska

2010

Neurologia i Neurochirurgia Polska

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Muscle biopsy is required to provide a definitive diagnosis in many neuromuscular disorders. Biopsy findings may indicate whether the pathological process is of neurogenic or myopathic origin. The muscle biopsy may give important information on the course of the disease (acute or chronic) and on the disease stage and progression. The interpretation of muscle biopsy, including histochemical and ultrastructural analysis, is a key factor in the diagnosis of muscular dystrophies, glycogenoses, inflammatory myopathies and congenital myopathies. An assessment of muscle biopsy on electron microscopy enables a definite diagnosis of oculopharyngeal muscular dystrophy, mitochondrial myopathy or inclusion body myositis. This paper presents an overview of general indications for muscle biopsy, biopsy procedures, as well as transportation and preparation of muscle tissue for final microscopic analysis. The interpretation of specific microscopic findings and a brief discussion on the clinical usefulness of muscle biopsy in the era of molecular diagnosis are also presented.

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Muscle Diseases in Elders: A 10-Year Retrospective Study

Abstract: Muscle diseases are not rare in elderly patients. Therefore, muscle biopsy constitutes a safe and useful tool for diagnosis because, if not performed, some potentially treatable diseases may be undiagnosed or misdiagnosed.

Cited by 12 publications

References 23 publications

Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility

Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility

Borderlines between Sarcopenia and Mild Late-Onset Muscle Disease

Rola biopsji mięśnia szkieletowego w diagnostyce chorób nerwowo-mięśniowych

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