Muscle Disease Associated With Renal Failure

Carleton, Henry; Pitts, William H.; Davidson, W. Sean; Roth, P.

doi:10.1001/archinte.1977.03630190089023

Cited by 12 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because patients with either PM/DM have ongoing muscle breakdown, they too may develop proteinuria on this basis (23). Although distinctly rare, a wide range of chronic glomerulonephritis has also been described to coexist with either PM or DM (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The most common pattern in idiopathic polymyositis is mesangial Despite the clinical similarities, there is ample evidence that PM and DM proceed by different immunopathological mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Renal involvement in patients with polymyositis and dermatomyositis

Lai

et al. 2004

International Journal of Clinical Practice

View full text Add to dashboard Cite

Renal involvement in patients with polymyositis (PM)/dermatomyositis (DM) is previously thought to be uncommon, but two main types of renal lesion have been described. First, acute tubular necrosis with renal failure related to myoglobulinemia and myoglobulinuria is a well-recognised feature of acute rhabdomyolysis. Second, chronic glomerulonephritis has been infrequently reported in a small group of patients with PM/DM. This study aims at investigating the incidence, severity and prognosis of renal disease in PM/DM patients, admitted to a single centre in a 10-year interval. The hospital records of 65 Taiwanese patients with PM/DM, examined between 1992 and 2002, were studied retrospectively. Of the 65 patients, 14 were found to have suffered varying degree of renal involvement, and the incidence rate was 21.5%. All the 14 patients had varying degree of haematuria and proteinuria. Acute tubular necrosis with renal failure developed in four patients with PM and in five patients with DM. Renal biopsy in two DM patients with overt proteinuria revealed IgA nephropathy in one and membranous nephropathy in the other. We, therefore, concluded that renal involvement in PM/DM patients is not as uncommon as previously thought.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal involvement in patients with polymyositis and dermatomyositis

Lai

et al. 2004

International Journal of Clinical Practice

View full text Add to dashboard Cite

show abstract

Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes

et al. 2006

View full text Add to dashboard Cite

A 58-year-old man concurrently developed polymyositis (PM), interstitial lung disease, and nephrotic-range proteinuria. Renal biopsy revealed focal mesangial proliferative glomerulonephritis (mesPGN) with depositions of immunoglobulin and complements. A combination therapy of corticosteroid, intravenous immunoglobulin, and cyclosporine was found very effective for the patient. Glomerulonephritis associated with PM/dermatomyositis (DM) is rare. In our review of related literature, mesPGN was exclusively observed in polymyositis while membranous nephropathy in DM. The mechanism underlying the association between myositis and glomerulonephritis remains to be elucidated.

show abstract