Muscle development : a view from adult myogenesis in Drosophila

Laurichesse, Quentin; Soler, C

doi:10.1016/j.semcdb.2020.02.009

Cited by 28 publications

(34 citation statements)

References 157 publications

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“…Adult flies have a pair of wings in the thoracic segment T2 and three pairs of legs in thoracic segments T1–T3, which are powered by specialized thoracic flight and appendicular muscles, respectively (figure in Table 2 ). Adult myogenesis has been reviewed recently in [ 199 , 200 ]. All adult thoracic muscles including the indirect flight muscles (IFMs), direct flight muscles (DFMs), and leg muscles possess a multi-fiber structure similar to vertebrate skeletal muscles.…”

Section: Muscle Diversification—on the Road To Muscle Homeostasismentioning

confidence: 99%

Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila

Poovathumkadavil

Jagla

2020

Cells

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In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as hatching in the embryo, crawling in the larva, and jumping and flying in adult flies all muscle components need to be maintained in a functionally stable or homeostatic state despite constant strain. This requires that the muscles develop in a coordinated manner with appropriate connections to other cell types they communicate with. Various signaling pathways as well as extrinsic and intrinsic factors are known to play a role during Drosophila muscle development, diversification, and homeostasis. In this review, we discuss genetic control mechanisms of muscle contraction, development, and homeostasis with particular emphasis on the contractile unit of the muscle, the sarcomere.

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Section: Muscle Diversification—on the Road To Muscle Homeostasismentioning

confidence: 99%

Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila

Poovathumkadavil

Jagla

2020

Cells

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“…The AMPs underlie the dorsal portion of the wing disc epithelium, the notum, which is the primordium of the dorsal thorax. During metamorphosis, these AMPs generate multiple muscle fibers which comprise the direct and indirect flight muscles (DFMs and IFMs, respectively) (reviewed by Bothe & Baylies, 2016;Gunage et al, 2017;Laurichesse & Soler, 2020).…”

Section: Introductionmentioning

confidence: 99%

Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

Everetts

Worley

Yasutomi

et al. 2021

eLife

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In both vertebrates and invertebrates, generating a functional appendage requires interactions between ectoderm-derived epithelia and mesoderm-derived cells. To investigate such interactions, we used single-cell transcriptomics to generate a temporal cell atlas of the Drosophila wing disc from two developmental time points. Using these data, we visualized gene expression using a multi-layered model of the wing disc and catalogued ligand-receptor pairs that could mediate signaling between epithelial cells and adult muscle precursors (AMPs). We found that localized expression of the FGF ligands, Thisbe and Pyramus, in the disc epithelium regulates the number and location of the AMPs. In addition, Hedgehog ligand from the epithelium activates a specific transcriptional program within adjacent AMP cells, defined by AMP-specific targets Neurotactin and midline, that is critical for proper formation of direct flight muscles. More generally, our annotated temporal cell atlas provides an organ-wide view of potential cell-cell interactions between epithelial and myogenic cells.

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“…Drosophila has a long history as a genetic model to study myogenesis, both the muscle structure and core myogenic programs being highly conserved between flies and mammals [19][20][21]. Drosophila myogenesis proceeds in two distinct waves, leading to the formation of adequate sets of muscles for the stage-specific modes of locomotion.…”

Section: Introductionmentioning

confidence: 99%

Drosophila, an Integrative Model to Study the Features of Muscle Stem Cells in Development and Regeneration

Boukhatmi

2021

Cells

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Muscle stem cells (MuSCs) are essential for muscle growth, maintenance and repair. Over the past decade, experiments in Drosophila have been instrumental in understanding the molecular and cellular mechanisms regulating MuSCs (also known as adult muscle precursors, AMPs) during development. A large number of genetic tools available in fruit flies provides an ideal framework to address new questions which could not be addressed with other model organisms. This review reports the main findings revealed by the study of Drosophila AMPs, with a specific focus on how AMPs are specified and properly positioned, how they acquire their identity and which are the environmental cues controlling their behavior and fate. The review also describes the recent identification of the Drosophila adult MuSCs that have similar characteristics to vertebrates MuSCs. Integration of the different levels of MuSCs analysis in flies is likely to provide new fundamental knowledge in muscle stem cell biology largely applicable to other systems.

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Muscle development : a view from adult myogenesis in Drosophila

Cited by 28 publications

References 157 publications

Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila

Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila

Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

Drosophila, an Integrative Model to Study the Features of Muscle Stem Cells in Development and Regeneration

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