Muscle degeneration in rotator cuff tears

Laron, Dominique; Samagh, Sanjum P.; Liu, Xuhui; Kim, Hubert T.

doi:10.1016/j.jse.2011.09.027

Cited by 84 publications

(95 citation statements)

References 91 publications

(93 reference statements)

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“…On the one hand, some authors support an intrinsic theory of damage, in which the degeneration of the tendon in aged patients would be the primary cause of the tear [9][10][11]. Others favour an extrinsic theory, where the RC tendons are chronically damaged by an impingement phenomenon, mainly under the anterior and lateral part of the acromion.…”

Section: Introductionmentioning

confidence: 99%

The acromial index is not predictive for failed rotator cuff repair

Meleán

Lichtenberg²,

Montoya

et al. 2013

International Orthopaedics (SICOT)

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Background The main objective of this study was to evaluate the association between the acromial index (AI) and the incidence of recurrent tears of the rotator cuff (RC) in a cohort of patients with full thickness tears who underwent arthroscopic primary repair. Methods A prognostic study of a prospective case series of 103 patients with full thickness RC tears was undertaken. The average age was 59.5 years (39-74) and follow-up was 30.81-months (12-72). True anterior-posterior X-rays were obtained during the pre-operative evaluation. Pre and post-operative magnetic resonance imaging (MRI) were recorded. Results Eighteen cases with recurrent tears (17.4 %) were seen on post-operative MRI. The average AI for patients with recurrent tears was 0.711±0.065 and for patients without recurrent tears 0.710±0.064 (p<0.05). A positive association between age and recurrent tears of the RC was noted (average ages: recurrent tears group 63±5.9 years; group without recurrent tears 58.8±7.5 years) (r=−0.216; p=0.029). We did not find an association between size of the primary tear and recurrent tears (r=−0.075; p<0.05) or between degrees of retraction of the primary and recurrent tears of the cuff (r=−0.073; p<0.05). We observed that 38.9 % of the recurrent tears cases presented with more than one tendon affected before the arthroscopy. At follow-up, none of these recurrent tears showed more than one tendon affected on MRI evaluation. ConclusionIn this study, we found that the AI radiological measurement is not a predictor for recurrent tears of the RC after primary arthroscopic repair.

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Section: Introductionmentioning

confidence: 99%

The acromial index is not predictive for failed rotator cuff repair

Meleán

Lichtenberg²,

Montoya

et al. 2013

International Orthopaedics (SICOT)

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“…The DNA microarray and qRT-PCR analyses revealed increased myogenesis in satellite cells from disused muscle, as evidenced by MYH2 and MYL1 expressions. These genes are responsible for myosin structure and function (Laron et al 2012). We also found that KCNA1 and HOXA11 levels were downregulated in disused muscle.…”

Section: Discussionmentioning

confidence: 51%

“…Although fatty infiltration and muscle atrophy are two main criteria for RCT severity (Laron et al 2012;Fermont et al 2014), the adipogenic precursor population in disused muscle has not been previously investigated. Although a small difference was observed in the population of adipogenic precursors between disused and intact muscles, a significant difference was found in the adipogenic precursor/satellite cell ratio.…”

Section: Discussionmentioning

confidence: 99%

Retained Myogenic Potency of Human Satellite Cells from Torn Rotator Cuff Muscles Despite Fatty Infiltration

Koide

Hagiwara

Tsuchiya

et al. 2018

Tohoku J. Exp. Med.

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Rotator cuff tears (RCTs) are a common shoulder problem in the elderly that can lead to both muscle atrophy and fatty infiltration due to less physical load. Satellite cells, quiescent cells under the basal lamina of skeletal muscle fibers, play a major role in muscle regeneration. However, the myogenic potency of human satellite cells in muscles with fatty infiltration is unclear due to the difficulty in isolating from small samples, and the mechanism of the progression of fatty infiltration has not been elucidated. The purpose of this study was to analyze the population of myogenic and adipogenic cells in disused supraspinatus (SSP) and intact subscapularis (SSC) muscles of the RCTs from the same patients using fluorescenceactivated cell sorting. The microstructure of the muscle with fatty infiltration was observed as a whole mount condition under multi-photon microscopy. Myogenic differentiation potential and gene expression were evaluated in satellite cells. The results showed that the SSP muscle with greater fatty infiltration surrounded by collagen fibers compared with the SSC muscle under multi-photon microscopy. A positive correlation was observed between the ratio of muscle volume to fat volume and the ratio of myogenic precursor to adipogenic precursor. Although no difference was observed in the myogenic potential between the two groups in cell culture, satellite cells in the disused SSP muscle showed higher intrinsic myogenic gene expression than those in the intact SSC muscle. Our results indicate that satellite cells from the disused SSP retain sufficient potential of muscle growth despite the fatty infiltration.

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“…Several morphological studies report intrafascicular, extrafascicular adipose accumulation and in intratendinous sites, and the origin of the adipocytes is not well defined. They also reveal that adipose infiltration may appear as early as 6 weeks after rupture [5] and that the degree of muscular degeneration and fat infiltration increases with its size [4]. Goutallier's Staging is based on the results evidenced by CT and divides fat infiltration into 5 stages (Table 2) [5].…”

Section: Muscle Degeneration and Fat Infiltrationmentioning

confidence: 99%

“…The ruptures of the hood are the most common musculotendinous ruptures [4], and the prevalence of massive ruptures ranges from 10% to 40% and increases with age [2,[5][6][7]. The first studies to use the term "solid rupture" date from the decades of 70, 80 [1].…”

Section: Introductionmentioning

confidence: 99%

Rotary Hood Massive Break Solutions? Massive Rotator Cuff Tear Solutions?

Panzina¹,

Gutierres²

2017

MOJOR

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Aim: review the current literature on options of treatment for massive rotator cuff tear Sources of data:The information was researched on the Pubmed using the following keywords: "massive", "rotator", "cuff ", "tear", "treatment". The survey was restricted to articles in english or portuguese, with less than 5 years. After selection 55 articles were used. Summary of data:Massive Rotator Cuff Tear is an orthopaedic challenge with a technically hard repair and a recurrence rate distinctively higher than the smaller tears rate. Its treatment has a high failure rate, which is influenced by factors such as patient's age, fatty degeneration and muscular retraction. The treatment choice should be based on patient's age, functional demands and symptoms. Conclusion:There are several options for the treatment of rotator cuff tears. Conservative treatment achieved good results in many patients, leaving many of them assymptomatic and with satisfactory function. The arthroscopic débridement, subacromial decompression and bicips tenotomy have as main objective the symptomatic relief and may be indicated in elderly patients with low functional demands, whose major complaint is pain. Repair should be tried specially in young symptomatic high-demand patients. Both hemiarthroplasty as reverse arthroplasty may be indicated in massive rupture and cuff arthropathy, being reverse arthroplasty the most effective treatment, although the not negligible mid-term complication rate.

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Muscle degeneration in rotator cuff tears

Cited by 84 publications

References 91 publications

The acromial index is not predictive for failed rotator cuff repair

The acromial index is not predictive for failed rotator cuff repair

Retained Myogenic Potency of Human Satellite Cells from Torn Rotator Cuff Muscles Despite Fatty Infiltration

Rotary Hood Massive Break Solutions? Massive Rotator Cuff Tear Solutions?

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