Muscle capillary basement membrane in juvenile diabetes mellitus

Dependency of Muscle Capillary Basement Membrane Thickness on the Duration of Diabetes

“…The most important results obtained are that the occurrence of BMT is a rare event in the first year following the diagnosis of diabetes and that a correlation between BMT and the duration of the disease is demonstrable (see Table 3). Thus, our findings are in agreement with those reported by Pardo et al, 1 Danowski et al, 2 and Kilo et al 3 but in contrast to those of Siperstein et al 6 ' 7 With respect to the frequency of basement membrane hypertrophy in diabetic subjects, Table 8 summarizes the values available from the literature determined by comparable methods. It is noteworthy that general agreement seems to exist between the different groups of investigators as far as the minimum BMT values from glutaraldehyde-fixed tissue are concerned.…”

Basement Membrane Thickness in Muscle Capillaries of Normal and Spontaneously Diabetic Macaca Nigra

“…1 " 8 Whether the prevalence and amount of thickening are related to the severity or duration of diabetes and to age, and whether the thickness is a useful diagnostic tool are matters of some debate. 1 " 9 Animal models with hereditary diabetes mellitus or glucose metabolic aberrations do not uniformly present muscle capillary basement membrane differences; greater thickness has been reported in some cases of induced diabetes 1011 although not in others. 1 2 1 3 A spontaneous diabetic syndrome was found among *The term "basement membrane" is used synonymously with basal lamina.…”

Muscle capillary basement membrane thickness in lipoatrophic diabetes

“…Several authors have observed increasing thickness depending on age of the patient, duration of the disease and quality of diabetes control (Pardo et al, 1972;Danowski et al, 1972;Kilo et al, 1972;Williamson and Kilo, 1977), others have failed to detect such a correlation (Siperstein et al, 1968;Vracko, 1970).…”

“…Yet, at least for the past six years her plasma glucose levels always exceeded 300 mg/100 ml, usually ranging between 400 and 600 rag/100 ml without ketoacidosis having developed. According to Danowski et al (1972) muscle capillary basement membrane thickening is not encountered in juvenile-onset diabetes of six years duration or less.…”