Muscle and Blood Hemoglobin in the Dolphin

Eichelberger, Lillian; Fetcher, E. S.; Geiling, E. M. K.; Vos, B. J.

doi:10.1126/science.90.2341.443

Cited by 13 publications

(3 citation statements)

References 2 publications

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“…These changes tended to be greater in pa tients of similar age suffering from COLD who also had lower values for intramuscu lar adenosine triphosphatase than healthy subjects of similar age [17], Studies with bi opsy technique also indicated that the muscle level of myoglobin underwent agerelated changes characterized by a slight (10%) increase in elderly [5], As evidenced by the present study, the muscle content of myoglobin is significantly decreased in patients with chronic or intermittent hy poxemia due to COLD. This finding may be somewhat unexpected, considering the numerous reports of an enhanced intra muscular level of myoglobin in aquatic mammals commonly exposed to hypoxia for long periods [7][8][9], However, other studies suggested that exercise may be even more important than hypoxemia in stimulating myoglobin synthesis [18][19][20][21], Whereas Pattengale and Holloszy [22] found an 80% increase in myoglobin in the quadriceps muscle of rats trained on a treadmill, Oshiro [23] found a rapid loss of myoglobin in denervated muscle of the dog. On the basis of these findings it ap pears that physical inactivity rather than hypoxemia may explain the subnormal muscular level of myoglobin in the present patients with COLD.…”

Section: Discussioncontrasting

confidence: 39%

“…The small but signifi cant elevation of myoglobin in the leg skeletal muscle of elderly subjects [5] may reflect a slight increase in the percentage distribution of the more myoglobin-rich type I fibers [6], The highest intramuscular levels of myoglobin have been observed in animals such as seals, whales, dolphins, and penguins subjected to long-term peri ods of hypoxemia [7][8][9]. Considering these findings, it appeared of interest to study myoglobin in the leg skeletal muscle of pa tients with chronic or intermittent hypox emia due to chronic obstructive lung dis ease (COLD).…”

Section: Introductionmentioning

confidence: 99%

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Myoglobin Content in Leg Skeletal Muscle in Patients with Chronic Obstructive Lung Disease

Möller¹,

Hellström²,

Hermansson³

1984

Respiration

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Myoglobin was determined in biopsy specimens from the quadriceps muscle of 3 female and 15 male 48-to 78-year-old patients with chronic obstructive lung disease. The patients were examined after an overnight rest. All but 2 were slightly to moderately hypoxemic. The myoglobin level was in all but 1 instance below the mean previously observed for apparently healthy subjects of similar age. The results are in line with earlier findings of an abnormal pattern of energy-rich phosphagens in the skeletal muscle of patients with chronic obstructive lung disease.

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Section: Discussioncontrasting

confidence: 39%

Section: Introductionmentioning

confidence: 99%

Myoglobin Content in Leg Skeletal Muscle in Patients with Chronic Obstructive Lung Disease

Möller¹,

Hellström²,

Hermansson³

1984

Respiration

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“…The differences and similarities between aquatic and terresfial mammals have been the subjects of several investigations (1)(2)(3). Studies of the gross and hlstologic anatomy of the lungs of several marine mammals have disclosed some structural modifications peculiar to these species (4,5).…”

mentioning

confidence: 99%

Studies on the Intermediary Carbohydrate Metabolism of Aquatic Animals

DuBois

Geiling

McBride

et al. 1948

Journal of General Physiology

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The differences and similarities between aquatic and terresfial mammals have been the subjects of several investigations (1-3). Studies of the gross and hlstologic anatomy of the lungs of several marine mammals have disclosed some structural modifications peculiar to these species (4, 5). The problems of adaptation of physical structure to an aquatic environment have been discussed by Kellogg (6) and the physiology of respiration of diving animals has been reviewed by Irving (7).The mechanisms for controlling the oxygen supply to the tissues and the ability of many marine mammals to undergo long periods of submergence have been of great interest. Irving, Scholander, and Grinnell (8) studied the respiration of dolphins during rest and diving and found that the resting oxygen consumption was less than that for seals but somewhat greater than for man per unit of weight. They reported that the lactic acid content of the muscle tissue of dolphins did not change significantly during the dive and that blood lactate values were not altered during or after diving, in contrast to the results obtained on rats and ducks (9) and on seals (8) in which lactic acid increased in the muscle during diving and in the blood during recovery.With some information on the over-all physiology of the dolphin at hand, it was of interest to study the intermediary cellular metabolism, since fundamental differences in the metabolism of aquatic and terrestial mammals must certainly reflect variations in enzymatic processes. Except for the findings of Manery, Welch, and Irving (10) that excised seal skeletal muscle can glycolyze to the same extent as rabbit muscle, data on the concentrations of the intermediates of glycolysis and on the respiratory and glycolytic enzymes in the

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