Muscicapines, a new class of guaiane-type sesquiterpene alkaloids from Croton muscicapa

Araujo-Junior, Vicente Toscano de; Silva, Marcelo Sobral da; Cunha, Emídio Vasconcelos Leitão da; Agra, Maria de Fátima; Athayde-Filho, Petrônio Filgueiras de; Vieira, Ivo José Curcino; Braz‐Filho, Raimundo; Barbosa-Filho, José Maria

doi:10.1590/s0103-50532005000400010

Cited by 11 publications

(6 citation statements)

References 3 publications

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“…Several of these plants are used in folk medicine as cicatrizing, anti-inflammatory, anticancer, against gastric problems, to treat hemorrhoids, and as agents to control uterine hemorrhages [ 8 ]. In Croton spp., the presence of secondary metabolites has been reported, as it is latex rich mainly in alkaloids, flavonoids, terpenes, terpenoids and ricin-type toxins [ 9 ]; due to the presence of these bioactive compounds, the Croton species are commonly used to treat cancer, hypertension, inflammation, rheumatism, bleeding gums, malaria, asthma, syphilitic ulcers, diabetes, pain, and ulcers [ 7 ]. The traditional uses of Croton spp.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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Croton ferrugineus Kunth is an endemic species of Ecuador used in traditional medicine both for wound healing and as an antiseptic. In this study, fresh Croton ferrugineus leaves were collected and subjected to hydrodistillation for extraction of the essential oil. The chemical composition of the essential oil was determined by gas chromatography equipped with a flame ionization detector and gas chromatography coupled to a mass spectrometer using a non-polar and a polar chromatographic column. The antibacterial activity was assayed against three Gram-positive bacteria, one Gram-negative bacterium and one dermatophyte fungus. The radical scavenging properties of the essential oil was evaluated by means of DPPH and ABTS assays. The chemical analysis allowed us to identify thirty-five compounds representing more than 99.95% of the total composition. Aliphatic sesquiterpene hydrocarbon trans-caryophyllene was the main constituent with 20.47 ± 1.25%. Other main compounds were myrcene (11.47 ± 1.56%), β-phellandrene (10.55 ± 0.02%), germacrene D (7.60 ± 0.60%), and α-humulene (5.49 ± 0.38%). The essential oil from Croton ferrugineus presented moderate activity against Candida albicans (ATCC 10231) with an MIC of 1000 μg/mL, a scavenging capacity SC50 of 901 ± 20 µg/mL with the ABTS method, and very strong antiglucosidase activity with an IC50 of 146 ± 20 µg/mL.

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Section: Introductionmentioning

confidence: 99%

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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“…Salatino et al (2007) described 35 alkaloid types from 14 Croton species. Among the species present in Brazilian caatinga, β-carboline alkaloids 2-ethoxycarbonyltetrahydroharman and 6-hydroxy-2-methyltetradydroharman have been isolated from C. moritibensis (Araújo-Júnior et al, 2004); anabasine and the novel guaiane-type alkaloids muscicapines A, B and C were isolated from roots of C. muscicapa (Araújo-Júnior et al, 2005). Alkaloids were also identified in C. campestris (Brito-Júnior et al, 2014) and C. rhamnifolius roots, and C. rhamnifolioides leaves, stem and roots (Randau et al, 2004); however, no compounds have been isolated.…”

Section: Discussionmentioning

confidence: 99%

Chemical composition, antioxidant and topical anti-inflammatory activities of Croton cordiifolius Baill. (Euphorbiaceae)

Alves¹,

Santos²,

Mendes³

et al. 2017

J. Med. Plants Res.

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Croton cordiifolius is widely used in Brazilian Caatinga folk medicine to treat general inflammation, pain, and gastrointestinal disturbances. Currently, its medicinal properties are not well understood, owing to the absence of chemical and pharmacological studies. The aims of this work were to analyze the chemical composition of C. cordiifolius stem bark and evaluate its in vitro antioxidant and in vivo anti-inflammatory activities. C. cordiifolius ethanolic extract (CcEE) was obtained by maceration, while essential oil (CcEO) was extracted by hydrodistillation in a Clevenger-type apparatus. The chemical composition was evaluated by thin-layer chromatography and GCMS. Total phenolics, flavonoids, and antioxidant activity were quantitated by spectrophotometry. Topical anti-inflammatory activity was evaluated by different ear edema models in mice. The major compounds in CcEO were α-pinene (51.76%) and β-pinene (19.08%). CcEE analysis indicated the presence of alkaloids, mono-and sesquiterpenes, flavonoids, phenylpropanoids, triterpenes, steroids, and coumarins. CcEE showed antioxidant activity in vitro. In a topical anti-inflammatory assay, CcEO showed no activity. On the contrary, CcEE inhibited ear edema induced by phorbol 12-myristate 13-acetate (PMA), arachidonic acid (AA), ethyl phenylpropriolate (EPP), and phenol. Probable mechanisms include inhibition of AA metabolite biosynthesis, vasoactive amine activity, and cytokine release/activity. These results corroborate the popular reputation of C. cordiifolius as an anti-inflammatory remedy.

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“…Arg. (Araújo-Júnior et al, 2004). In this paper we report the chemical investigation of Croton moritibensis Baill, a native shrub from our region, where it is popularly known as "velame-preto".…”

Section: Introductionmentioning

confidence: 99%

Alkaloids and Diterpenes FromCroton moritibensis

Araujo-Junior

Silva

Cunha

et al. 2004

Pharmaceutical Biology

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Muscicapines, a new class of guaiane-type sesquiterpene alkaloids from Croton muscicapa

Cited by 11 publications

References 3 publications

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Chemical composition, antioxidant and topical anti-inflammatory activities of Croton cordiifolius Baill. (Euphorbiaceae)

Alkaloids and Diterpenes FromCroton moritibensis

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