Muscarinic acetylcholine receptors in the mouse esophagus: focus on intraganglionic laminar endings (IGLEs)

Abstract

Acetylcholine probably released from varicosities of both extrinsic and intrinsic origin may influence a subpopulation of esophageal IGLEs via M2 and M1-receptors.

Gut-brain communication and obesity: understanding functions of the vagus nerve

“…Ultrastructural observations also support a mechanosensory function (31). Combined with recent immunohistochemical data, ultrastructural observations suggest additional chemosensory functions and complex interactions of IGLEs with myenteric neurons and calcitonin gene-related peptide-positive spinal afferents passing through myenteric ganglia (31)(32)(33), suggesting additional chemosensory functions. Finally, mucosal endings have been traced to the entire gastrointestinal tract, with the highest density in the villi and crypts of the proximal small intestine (34,35).…”

Funktionelle Anatomie der Interozeption

“…Es sind niederschwellige Mechanosensoren, die Druck und Wandspannung registrieren [30]. Immunhistochemische und elektronenmikroskopische Befunde nähren Spekulationen über Wechselwirkungen zwischen IGLE und enterischen Neuronen, die jedoch noch ihrer funktionellen Bestätigung harren [31,32].…”