Muscarine, imidaozle, oxazole and thiazole alkaloids

Abstract

Covering: July 2010 to June 2012. Previous review: Nat. Prod. Rep., 2011, 28, 1143-1191. Structurally diverse alkaloids containing five-membered heterocyclic subunits, such as imidazole, oxazole, thiazole, as well as their saturated congeners, are widely distributed in terrestrial and marine organisms and microorganisms. These naturally occurring secondary metabolites often exhibit extensive and pharmacologically important biological activities. The latest progress involving isolation, biological activities, chemical synthetic studies, and biosynthetic pathways of these natural products has been summarized in this review.

Highly Efficient One-Pot Synthesis of 2,4-Disubstituted Thiazoles Using Au(I) Catalyzed Oxidation System at Room Temperature

“…[1][2][3][4][5][6][7][8][9]. It was the derivatives of 2,4-disubstituted thiazole that acted as active ingredient in many bioactive natural products and pharmaceuticals, such as mycothiazole, sanguinamide B, and archazolid A (Figure 1) [5,6]. Much effort has been put into the preparation of thiazole compounds, which became a much-talked-about topic in recent years [10,11].…”

“…This special thiazole ring structure endows thiazoles with wide application in chemical, pharmaceutical, biological, and material sciences, etc. [1][2][3][4][5][6][7][8][9]. It was the derivatives of 2,4-disubstituted thiazole that acted as active ingredient in many bioactive natural products and pharmaceuticals, such as mycothiazole, sanguinamide B, and archazolid A (Figure 1) [5,6].…”

Thiazoles in Peptides and Peptidomimetics

“…[1,3,[79][80][81]] Only a few thiazole-macrocycles can be accommodated within the size constraints of this article. The first to be considered here is largazole (90, Fig.…”

“…Thiazole (C 3 H 3 NS) is a five-membered heterocyclic aromatic compound found in many natural products [1][2][3][4] including vitamin B1, and has been widely incorporated into synthetic molecules including pharmaceuticals, [5] catalysts [6] and dyes [7].…”

Highly Efficient, Environment-Friendly, One-Pot Synthesis of 2-Substituted 4-Formylimidazoles from 4-Acylaminoisoxazoles

“…2 Some alkaloids also contain an imidazole ring and exhibit many prominent bioactivities such as antimicrobial activity and cytotoxicity. 1,3 Recently, other diverse, interesting bioactivities of imidazoles, such as antikinase IspE activity, 4 tubulin depolymerization inhibition 5 and anti-cyclooxygenase activity, 6 have been demonstrated. Moreover, imidazoles are important precursors of ligands and polymers.…”