Musashi1, a potential prognostic marker in esophageal squamous cell carcinoma

Qin, Guohui; Lian, Jingyao; Yue, Dongli; Chen, Xinfeng; Nan, Shufeng; Qi, Yu; Li, Bing; Cui, Guanghui; Li, Xiangnan; Zhao, Song; Zhang, Yi

doi:10.3892/or.2017.5809

Cited by 13 publications

(10 citation statements)

References 36 publications

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“…Previous studies have proven that RNA-binding proteins are crucial for cell proliferation and apoptosis during the process of tumorigenesis (23-25). As a member of the MSI family of RNA-binding proteins, MSI1 was found to be overexpressed in several types of cancer, including non-small-cell lung cancer (14), osteosarcoma (21), and esophageal SCC (17).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that tumor stem cells are responsible for tumor metastasis (6,7), and an increasing number of stem cell-related genes have been proven to be involved in tumorigenesis (8,9). MSI1 is a RNA-binding protein of the Musashi family that has been found to be associated with certain cancers, including glioma (10), cervical cancer (11), gastric cancer (12) and lung cancer (13,14). In addition, MSI1 appears to be a prognostic marker for esophageal SCC (15) and glioma (16).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, MSI1 appears to be a prognostic marker for esophageal SCC (15) and glioma (16). Furthermore, MSI1 has been found to activate the AKT (14) and Notch (17,18) signaling pathways in certain types of cancer; however, its role in OSCC remains unclear. The aim of the present study was to investigate the role of MSI1 in OSCC progression and elucidate the underlying mechanism, as well as determine whether MSI1 acts as an oncogene in OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

et al. 2019

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Musashi RNA-binding protein 1 (MSI1) is highly expressed in several types of cancer; however, its role in oral squamous cell carcinoma (OSCC) remains unknown. The purpose of this study was to investigate the probable mechanism underlying the involvement of MSI1 in OSCC. The results demonstrated that MSI1 was upregulated in OSCC tissues, but not in adjacent healthy tissues. MSI1 silencing resulted in decreased cell proliferative, invasive and migrative capacity. In addition, MSI1 silencing led to cell cycle arrest at the S phase, downregulation of c-Myc and cyclin D1, and upregulation of p21 and p27 levels. Additional studies demonstrated that MSI1 suppression inhibited the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Accordingly, the findings of the present study suggested that MSI1 silencing can suppress OSCC cell proliferation and progression, in part by inhibiting the activation of the c-Myc/STAT3 pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

et al. 2019

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“…Extensive research in the past few decades has identified CSCs in multiple solid tumors, including colon [ 30 ], brain [ 31 ], lung [ 32 ], liver [ 33 ], and other cancers [ 34 ]. CSCs are generally defined by their distinct and specific surface antigen expression [ 35 , 36 , 37 ] and by their capacity to generate spherical colonies from single cell in suspension cultures [ 38 ]. Moreover, CSCs exhibit a higher resistance to standard chemotherapy [ 39 ] and radiation therapy [ 40 ] through deregulated apoptosis and survival signaling.…”

Section: Cancer Stem Cells: Implications For Hepatocarcinogenesismentioning

confidence: 99%

Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer

Lee

Hong

2020

Cancers

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The first report of cancer stem cell (CSC) from Bruce et al. has demonstrated the relatively rare population of stem-like cells in acute myeloid leukemia (AML). The discovery of leukemic CSCs prompted further identification of CSCs in multiple types of solid tumor. Recently, extensive research has attempted to identity CSCs in multiple types of solid tumors in the brain, colon, head and neck, liver, and lung. Based on these studies, we hypothesize that the initiation and progression of most malignant tumors rely largely on the CSC population. Recent studies indicated that stem cell-related markers or signaling pathways, such as aldehyde dehydrogenase (ALDH), CD133, epithelial cell adhesion molecule (EpCAM), Wnt/β-catenin signaling, and Notch signaling, contribute to the initiation and progression of various liver cancer types. Importantly, CSCs are markedly resistant to conventional therapeutic approaches and current targeted therapeutics. Therefore, it is believed that selectively targeting specific markers and/or signaling pathways of hepatic CSCs is an effective therapeutic strategy for treating chemotherapy-resistant liver cancer. Here, we provide an overview of the current knowledge on the hepatic CSC hypothesis and discuss the specific surface markers and critical signaling pathways involved in the development and maintenance of hepatic CSC subpopulations.

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“…In contrast, it has been reported that there was increased expression of MSI1 in Chinese ESCC samples compared with normal margins. Moreover, there were significant correlations between stage, lymph node involvement, and the levels of MSI1 expression [39].…”

Section: Main Textmentioning

confidence: 99%

Genetic and molecular bases of esophageal Cancer among Iranians: an update

2019

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Background Esophageal cancer is one of the leading causes of cancer related deaths among the Iranians. There is still a high ratio of mortality and low 5 years survival which are related to the late onset and diagnosis. Majority of patients refer for the treatment in advanced stages of tumor progression. Main body It is required to define an efficient local panel of diagnostic and prognostic markers for the Iranians. Indeed such efficient specific panel of markers will pave the way to decrease the mortality rate and increase the 5 years survival among the Iranian patients via the early diagnosis and targeted therapy. Conclusion in present review we have reported all of the molecular markers in different signaling pathways and cellular processes which have been assessed among the Iranian esophageal cancer patients until now.

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Musashi1, a potential prognostic marker in esophageal squamous cell carcinoma

Cited by 13 publications

References 36 publications

Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

Knockdown of MSI1 inhibits the proliferation of human oral squamous cell carcinoma by inactivating STAT3 signaling

Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer

Genetic and molecular bases of esophageal Cancer among Iranians: an update

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