2008
DOI: 10.1182/blood-2007-08-106500
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Murine neonates develop vigorous in vivo cytotoxic and Th1/Th2 responses upon exposure to low doses of NIMA-like alloantigens

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Cited by 25 publications
(25 citation statements)
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“…The relationship between tolerogenic effect and MMc are consistent with a report of Dutta et al They described the correlation between MMc and NIMA-specific Treg capable of suppressing both delayed type hypersensitivity and lymphoproliferative responses of effector T cells in a conventional NIMA mouse model (van Rood and Claas 1990;Andrassy, Kusaka et al 2003). Opiela et al described that transient exposure to low levels of NIMA alloantigens in early life may lead to long-term priming for both cytotoxic and helper T cell functions (Opiela, Levy et al 2008). …”
Section: Reactivity To Mismatched Histocompatibility Antgens; Tolerogsupporting
confidence: 83%
“…The relationship between tolerogenic effect and MMc are consistent with a report of Dutta et al They described the correlation between MMc and NIMA-specific Treg capable of suppressing both delayed type hypersensitivity and lymphoproliferative responses of effector T cells in a conventional NIMA mouse model (van Rood and Claas 1990;Andrassy, Kusaka et al 2003). Opiela et al described that transient exposure to low levels of NIMA alloantigens in early life may lead to long-term priming for both cytotoxic and helper T cell functions (Opiela, Levy et al 2008). …”
Section: Reactivity To Mismatched Histocompatibility Antgens; Tolerogsupporting
confidence: 83%
“…They described the correlation between MMc and NIMA-specific regulatory T cells capable of suppressing both delayed-type hypersensitivity and lymphoproliferative responses of effector T cells in conventional NIMA mouse model. Opiela et al (33) described that transient exposure to low levels of NIMA alloantigens in early life may lead to long-term priming for both cytotoxic and Th cell functions. In contrast, Aoyama et al (7) showed that both oral and in utero exposures to NIMA are required for the maximum induction of tolerance.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, noninherited maternal Ags (NIMAs) can be transferred to the fetus across the placenta or to the neonate via breast milk. Several studies demonstrated that, depending on the nature and the level of NIMAlike alloantigens present in newborns, tolerance or priming responses may take place, leading to long-term heart allograft survival (43) and suppression of graft-versus-host reaction (44) or to the opposite: acute rejection of renal grafts (45) and vigorous T cell responses (46). A recent study demonstrated that the human fetal immune system exposed to maternal microchimerism is able to mount NIMA alloantigen-specific CD4 + and CD8 + T cell responses and that CD4 + CD25 + Foxp3 + T cells able to control the fetal alloreactive T cells were induced by maternal alloantigens (47).…”
Section: Discussionmentioning
confidence: 99%