Murine natural anti‐tumor antibodies. II. The contribution of natural antibodies to tumor surveillance

Chow, Donna A.; Wolosin, L B; Greenberg, Arnold H.

doi:10.1002/ijc.2910270407

Cited by 41 publications

(14 citation statements)

References 36 publications

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“…Macrophage-resistant tumor cell lines are rare (17,119,(129)(130)(131)(132), but Berd and Mastrangelo (133) reported the isolation of an LI210 line which was resistant to killing by Coo'nebacterium parvum (CP)-activated peritoneal exudate cells (PECs). Evidence that the effector PECs were macrophages included adherence, phagocytic activity, sensitivity to silica poisoning, absence of cytolytic activity in splenocytes from CP-treated mice and equivalent activity of PECs from both young and old CPtreated mice.…”

Section: Mechanisms Of Intratumor Heterogeneitymentioning

confidence: 99%

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Intratumor immunologic heterogeneity

Miller

1982

Cancer Metast Rev

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Tumor cells express a great variety of antigens including tumor specific transplantation antigens, tumor-associated antigens, differentiation antigens, histocompatibility antigens, lectin-binding sites and receptors for natural killer cells and natural antibodies. These antigens are distributed unevenly on tumor subpopulations and each subpopulation may induce different immune responses to the same determinant. Intratumor immunologic heterogeneity arises early in cancer, possibly during preneoplasia, and exists throughout the course of progression. Metastatic subpopulations are not generally less antigenic than subpopulations within primary tumors. Different arrays of antigenic determinants are displayed by subpopulations but variability in cell surface expression of a single determinant is also a fundamental type of immunologic heterogeneity. Antigenic specificity patterns commonly reveal one-way cross-reactions between tumor subpopulations. One-way cross-reactions might occur due to quantitative differences, cell-cycle variations, modulation, masking, H-2 expression and restriction phenomena, or alteration in the carbohydrate side-chains of glycoproteins. Interactions which occur when subpopulations co-exist may alter immune responses so that the response to the mixture is not the sum of the responses to the individual subpopulations. It is suggested that the exploitation of the mechanisms involved in immunologic heterogeneity may lead to new therapeutic approaches and that the great diversity of determinants expressed by tumor cells could lead to development of multivalent panel of monoclonal antisera which, acting synergistically, could preferentially lyse tumor cells.

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Section: Mechanisms Of Intratumor Heterogeneitymentioning

confidence: 99%

“…Variants differing in susceptibility to C'-dependent NAb lysis have been isolated by cloning from L5178Y lymphoma (135) and SL2 lymphomas (129). NAb lysis may involve synergistic cooperation between antibodies against multiple specificities on a tumor cell.…”

Section: Mechanisms Of Intratumor Heterogeneitymentioning

confidence: 99%

Intratumor immunologic heterogeneity

Miller

1982

Cancer Metast Rev

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“…The new information obtained is that neither T cell nor NK activity was implicated in early CHP-100 cell death, which was seen in all mice within 24 hours. This early cell death could reflect other forms of natural immunity [32][33][34]. Alternatively, it might simply reflect inability of the murine host to support growth of the human cell line, perhaps coupled to the action of general inflammatory mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Human neuroblastoma cell growth in xenogeneic hosts: comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes

1990

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We have examined two features of neuroblastoma cells that had not been well-characterized in a xenogeneic model: The cells display unusual immunologic properties in other experimental systems, and the original tumors display widespread and characteristic patterns of metastasis. To determine the most appropriate immunodeficient host for primary tumor growth, T cell-deficient nude mice, NK-deficient beige mice, beige-nudes, and controls were injected with the well-characterized line CHP-100. To define the pattern of tumor spread, complete autopsies were performed following subcutaneous, intraperitoneal and intravenous injections. CHP-100 consistently formed subcutaneous tumors in T cell-deficient mice (nude and beige-nude), but not in T cell-competent mice (beige, heterozygous nu/+ and bg/+, or wild-type). The growth rate and final size of the subcutaneous tumors were not greater in beige-nudes than in nudes. All mice showed early CHP-100 cell death after subcutaneous injection; the nature of the immunodeficiency was more relevant for the surviving subpopulation. Widespread dissemination was seen following intravenous injection, particularly in beige-nudes. Aspects of the growth patterns were appropriate to the tumor of origin. The behavior in immunodeficient mice suggests that T cells can play a role in controlling the growth of these cells; the next steps will be to define the effector mechanisms, and to determine if they can be exploited for human patients. The hematogenous spread following intravenous injection suggests that insights into the control of blood-borne tumor may also come from further study of this model.

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“…The measurement of lysis by splenic NK cells from polyinosinic-polycytidylic-acid-stimulated syngeneic C3H/HeN and allogeneic CBA/J mice (100 pg i.p. 20 hr previously) was carried out in an 18-hr assay using "Cr-labelled target cells at effector-to-target ratios of 150:1, 75:l and 37.5:1 (Chow et al, 1981). Cytolysis was calculated according to the equation: Western blotting Expression of ras p21 was determined by Western blotting as described previously (Tough and Chow, 1991).…”

Section: Natural Killer Cell Cytolysismentioning

confidence: 99%

Regulation of natural antibody binding and susceptibility to natural killer cells through Zn⁺⁺‐inducible ras oncogene expression

Tough

Haliotis

Chow

1992

Intl Journal of Cancer

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Changes in the natural resistance phenotype were examined for the 2H1, 10T 1/2 cells expressing the activated human H-ras oncogene under the transcriptional regulation of the zinc-inducible mouse metallothionein-I promoter. Culture of the cells in 50 microM ZnSO4 induced an increase in ras protein p21 levels which were maximal within 1 day. Natural-antibody (NAb) binding was significantly increased following 2 days of cell culture in ZnSO4 and continued to increase up to 4 days. The increased NAb binding returned to uninduced levels within 2 days following the removal of added zinc ions from the culture medium. The cells also exhibited a significant increase in natural killer (NK) cell sensitivity following 2 days in ZnSO4. This was maintained as long as the zinc was in the medium, but returned to uninduced levels within 1 day following its removal. The results show that NAb binding and susceptibility to NK cells increased following ras oncogene expression in 10T 1/2 cells and that both parameters were regulated by p21 expression. Repeated i.v. administration of whole-serum NAb prior to tumor inoculation reduced the number of early tumors following s.c. injection of Zn(++)-induced 2Hl cells into Zn(++)-treated C3H/HeN mice, consistent with an in vivo role for NAb in the defense against ras-transformed cells. In contrast, small but statistically significant reductions in NAb binding were observed following v-H-ras transformation of NIH 3T3 cells or v-src transformation of 10T 1/2. The data argue for an NAb- and NK-cell-susceptible phase of ras-induced tumor development which is a prerequisite for these mediators to contribute to a first line of defense against incipient neoplasia, and suggest that characteristics of the recipient cell and the transforming oncogene are important in determining the natural resistance phenotype.

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Murine natural anti‐tumor antibodies. II. The contribution of natural antibodies to tumor surveillance

Cited by 41 publications

References 36 publications

Intratumor immunologic heterogeneity

Intratumor immunologic heterogeneity

Human neuroblastoma cell growth in xenogeneic hosts: comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes

Regulation of natural antibody binding and susceptibility to natural killer cells through Zn⁺⁺‐inducible ras oncogene expression

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Murine natural anti‐tumor antibodies. II. The contribution of natural antibodies to tumor surveillance

Cited by 41 publications

References 36 publications

Intratumor immunologic heterogeneity

Intratumor immunologic heterogeneity

Human neuroblastoma cell growth in xenogeneic hosts: comparison of T cell-deficient and NK-deficient hosts, and subcutaneous or intravenous injection routes

Regulation of natural antibody binding and susceptibility to natural killer cells through Zn++‐inducible ras oncogene expression

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Regulation of natural antibody binding and susceptibility to natural killer cells through Zn⁺⁺‐inducible ras oncogene expression