Murine Models for Leptospirosis Kidney Disease

Abstract

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Understanding the Renal Fibrotic Process in Leptospirosis

“…On the other hand, rats and mice are suitable models to study carrier status and chronic disease. Although mice do not present signs of the disease, and their lesions are considered mild to moderate, good models of chronic leptospirosis in those animals have been developed, while some underlying mechanisms involved in the persistence of Leptospira and fibrosis induction have begun to be elucidated [ 142 , 150 , 152 , 158 ].…”

Narrative review of generalities of the genus Leptospira and its virulence factors associated with renal pathophysiology

“…From a general point of view, the nitrogen compounds in the blood and thrombocytes are restored in two weeks, the protein in urine and the clearance of creatinine in three months, and the urinary concentration in six months. 2,4,26,30…”

“…Leptospirosis is a re-emerging infectious disease and one of the main zoonotic causes of morbidity and mortality affecting animals and humans worldwide. [1][2][3] It is estimated that it affects approximately 1.03 million people each year. [4][5][6] This disease is caused by pathogenic bacteria belonging to the genus Leptospira, as well as the Leptospiraceae family and Spirochaetales order.…”