Murine Model of Airway Fibrosis has Anatomic, Physiologic, and Molecular Congruency to Human iSGS
Laura M. Mafla,
Rafael Ospino,
Raymond J. So
et al.
Abstract:ObjectiveTo narrow knowledge gaps in the pathophysiology of idiopathic subglottic stenosis (iSGS) through comparison of a murine subglottic stenosis model with iSGS.Study DesignIn vivo animal study.SettingAcademic institution.MethodsMurine samples/measurements were obtained from mice that underwent chemomechanical injury with a wire brush and bleomycin. Human samples/measurements were obtained from iSGS patients. Anatomic, physiologic, and epithelial molecular data were collected using histology, human peak ex… Show more
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